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Updated November 2019
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Protein Info
Short Name:
COBL
Full Name:
Protein cordon-bleu
Alias:
Cordon-bleu; KIAA0633
Type:
Cell development/differentiation; Actin binding protein
Mass (Da):
135617
Number AA:
1261
UniProt ID:
O75128
International Prot ID:
IPI00384529
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
A
P
R
A
S
A
A
K
P
P
T
G
Site 2
T13
A
S
A
A
K
P
P
T
G
R
K
M
K
A
R
Site 3
T30
P
P
P
G
K
A
A
T
L
H
V
H
S
D
Q
Site 4
S35
A
A
T
L
H
V
H
S
D
Q
K
P
P
H
D
Site 5
S47
P
H
D
G
A
L
G
S
Q
Q
N
L
V
R
M
Site 6
S77
P
S
G
L
E
K
R
S
V
L
N
G
S
H
A
Site 7
S110
H
A
L
E
I
R
S
S
E
T
Q
Q
P
L
S
Site 8
T112
L
E
I
R
S
S
E
T
Q
Q
P
L
S
F
K
Site 9
S117
S
E
T
Q
Q
P
L
S
F
K
P
N
T
L
I
Site 10
S154
P
P
K
V
P
E
K
S
V
R
L
V
V
N
Y
Site 11
S172
Q
K
A
V
V
R
V
S
P
E
V
P
L
Q
N
Site 12
S210
A
G
E
E
L
E
L
S
K
S
L
N
E
L
G
Site 13
S212
E
E
L
E
L
S
K
S
L
N
E
L
G
I
K
Site 14
Y222
E
L
G
I
K
E
L
Y
A
W
D
N
R
R
E
Site 15
T230
A
W
D
N
R
R
E
T
F
R
K
S
S
L
G
Site 16
S234
R
R
E
T
F
R
K
S
S
L
G
N
D
E
T
Site 17
S235
R
E
T
F
R
K
S
S
L
G
N
D
E
T
D
Site 18
T241
S
S
L
G
N
D
E
T
D
K
E
K
K
K
F
Site 19
S258
F
F
K
V
N
K
R
S
N
S
K
G
C
L
T
Site 20
S260
K
V
N
K
R
S
N
S
K
G
C
L
T
T
P
Site 21
T265
S
N
S
K
G
C
L
T
T
P
N
S
P
S
M
Site 22
T266
N
S
K
G
C
L
T
T
P
N
S
P
S
M
H
Site 23
S269
G
C
L
T
T
P
N
S
P
S
M
H
S
R
S
Site 24
S271
L
T
T
P
N
S
P
S
M
H
S
R
S
L
T
Site 25
S274
P
N
S
P
S
M
H
S
R
S
L
T
L
G
P
Site 26
S276
S
P
S
M
H
S
R
S
L
T
L
G
P
S
L
Site 27
T278
S
M
H
S
R
S
L
T
L
G
P
S
L
S
L
Site 28
S292
L
G
S
I
S
G
V
S
V
K
S
E
M
K
K
Site 29
S295
I
S
G
V
S
V
K
S
E
M
K
K
R
R
A
Site 30
S308
R
A
P
P
P
P
G
S
G
P
P
V
Q
D
K
Site 31
S317
P
P
V
Q
D
K
A
S
E
K
V
S
L
G
S
Site 32
S321
D
K
A
S
E
K
V
S
L
G
S
Q
I
D
L
Site 33
S324
S
E
K
V
S
L
G
S
Q
I
D
L
Q
K
K
Site 34
S347
P
P
Q
P
P
P
P
S
P
L
I
P
N
R
T
Site 35
T354
S
P
L
I
P
N
R
T
E
D
K
E
E
N
R
Site 36
S363
D
K
E
E
N
R
K
S
T
M
V
S
L
P
L
Site 37
T364
K
E
E
N
R
K
S
T
M
V
S
L
P
L
G
Site 38
S367
N
R
K
S
T
M
V
S
L
P
L
G
S
G
S
Site 39
S372
M
V
S
L
P
L
G
S
G
S
H
C
S
P
D
Site 40
S374
S
L
P
L
G
S
G
S
H
C
S
P
D
G
A
Site 41
S377
L
G
S
G
S
H
C
S
P
D
G
A
P
Q
V
Site 42
S386
D
G
A
P
Q
V
L
S
E
A
E
E
T
V
S
Site 43
S393
S
E
A
E
E
T
V
S
V
G
S
C
F
A
S
Site 44
S400
S
V
G
S
C
F
A
S
E
D
T
T
E
D
S
Site 45
T403
S
C
F
A
S
E
D
T
T
E
D
S
G
V
M
Site 46
T404
C
F
A
S
E
D
T
T
E
D
S
G
V
M
S
Site 47
S407
S
E
D
T
T
E
D
S
G
V
M
S
S
P
S
Site 48
S411
T
E
D
S
G
V
M
S
S
P
S
D
I
V
S
Site 49
S412
E
D
S
G
V
M
S
S
P
S
D
I
V
S
L
Site 50
S414
S
G
V
M
S
S
P
S
D
I
V
S
L
D
S
Site 51
S418
S
S
P
S
D
I
V
S
L
D
S
Q
Q
D
S
Site 52
S421
S
D
I
V
S
L
D
S
Q
Q
D
S
M
K
Y
Site 53
S425
S
L
D
S
Q
Q
D
S
M
K
Y
K
D
K
W
Site 54
T434
K
Y
K
D
K
W
A
T
D
Q
E
D
C
S
D
Site 55
S440
A
T
D
Q
E
D
C
S
D
Q
D
L
A
G
T
Site 56
T447
S
D
Q
D
L
A
G
T
P
D
L
G
P
Q
K
Site 57
S455
P
D
L
G
P
Q
K
S
P
L
W
E
K
N
G
Site 58
S463
P
L
W
E
K
N
G
S
E
N
S
H
L
R
T
Site 59
S466
E
K
N
G
S
E
N
S
H
L
R
T
E
K
A
Site 60
T470
S
E
N
S
H
L
R
T
E
K
A
V
T
A
S
Site 61
T475
L
R
T
E
K
A
V
T
A
S
N
D
E
E
D
Site 62
T492
I
A
G
E
F
R
K
T
L
A
E
L
D
E
D
Site 63
S506
D
L
E
E
M
E
D
S
Y
E
T
D
T
S
S
Site 64
Y507
L
E
E
M
E
D
S
Y
E
T
D
T
S
S
L
Site 65
T509
E
M
E
D
S
Y
E
T
D
T
S
S
L
T
S
Site 66
T511
E
D
S
Y
E
T
D
T
S
S
L
T
S
S
I
Site 67
S512
D
S
Y
E
T
D
T
S
S
L
T
S
S
I
H
Site 68
S513
S
Y
E
T
D
T
S
S
L
T
S
S
I
H
G
Site 69
T515
E
T
D
T
S
S
L
T
S
S
I
H
G
A
S
Site 70
S516
T
D
T
S
S
L
T
S
S
I
H
G
A
S
N
Site 71
S517
D
T
S
S
L
T
S
S
I
H
G
A
S
N
H
Site 72
S548
V
T
F
I
G
E
V
S
D
D
P
V
D
S
G
Site 73
S554
V
S
D
D
P
V
D
S
G
L
F
S
N
R
N
Site 74
S558
P
V
D
S
G
L
F
S
N
R
N
N
N
A
G
Site 75
S566
N
R
N
N
N
A
G
S
F
D
S
E
G
V
A
Site 76
S569
N
N
A
G
S
F
D
S
E
G
V
A
S
R
R
Site 77
S574
F
D
S
E
G
V
A
S
R
R
D
S
L
A
P
Site 78
S578
G
V
A
S
R
R
D
S
L
A
P
L
Q
A
E
Site 79
S587
A
P
L
Q
A
E
H
S
Q
P
H
E
K
A
R
Site 80
S616
K
G
I
R
V
A
L
S
N
I
S
K
D
G
N
Site 81
T627
K
D
G
N
L
M
E
T
A
P
R
V
T
S
F
Site 82
T632
M
E
T
A
P
R
V
T
S
F
A
S
N
L
H
Site 83
S633
E
T
A
P
R
V
T
S
F
A
S
N
L
H
T
Site 84
T640
S
F
A
S
N
L
H
T
D
N
L
N
A
K
V
Site 85
Y652
A
K
V
K
D
K
V
Y
G
C
A
D
G
E
R
Site 86
T663
D
G
E
R
T
Q
A
T
E
R
V
N
S
Q
P
Site 87
S668
Q
A
T
E
R
V
N
S
Q
P
V
N
E
K
D
Site 88
S687
N
A
A
L
A
P
T
S
W
H
Q
R
G
Q
N
Site 89
S698
R
G
Q
N
P
G
K
S
Y
R
L
K
H
G
L
Site 90
Y708
L
K
H
G
L
T
T
Y
K
I
I
P
P
K
S
Site 91
Y720
P
K
S
E
M
R
C
Y
D
R
D
V
S
L
S
Site 92
S725
R
C
Y
D
R
D
V
S
L
S
T
G
A
I
K
Site 93
S727
Y
D
R
D
V
S
L
S
T
G
A
I
K
I
D
Site 94
S741
D
E
L
G
N
L
V
S
P
H
A
T
G
I
R
Site 95
S751
A
T
G
I
R
I
I
S
L
S
S
S
V
P
E
Site 96
S755
R
I
I
S
L
S
S
S
V
P
E
A
E
S
Q
Site 97
S761
S
S
V
P
E
A
E
S
Q
P
I
G
K
V
R
Site 98
S775
R
E
F
W
R
C
N
S
V
E
K
H
L
G
R
Site 99
S784
E
K
H
L
G
R
P
S
E
S
S
A
R
G
P
Site 100
S786
H
L
G
R
P
S
E
S
S
A
R
G
P
P
S
Site 101
S787
L
G
R
P
S
E
S
S
A
R
G
P
P
S
T
Site 102
S793
S
S
A
R
G
P
P
S
T
P
V
P
T
Q
T
Site 103
T794
S
A
R
G
P
P
S
T
P
V
P
T
Q
T
Q
Site 104
T798
P
P
S
T
P
V
P
T
Q
T
Q
N
P
E
S
Site 105
T800
S
T
P
V
P
T
Q
T
Q
N
P
E
S
R
L
Site 106
S805
T
Q
T
Q
N
P
E
S
R
L
Q
A
D
P
K
Site 107
S815
Q
A
D
P
K
P
I
S
P
Q
Q
K
S
A
H
Site 108
S820
P
I
S
P
Q
Q
K
S
A
H
H
E
G
R
N
Site 109
T838
E
G
R
N
Q
P
P
T
M
G
M
G
H
V
R
Site 110
T855
A
A
H
T
T
E
V
T
F
L
K
P
Q
R
R
Site 111
T863
F
L
K
P
Q
R
R
T
S
S
Q
Y
V
A
S
Site 112
S864
L
K
P
Q
R
R
T
S
S
Q
Y
V
A
S
A
Site 113
S865
K
P
Q
R
R
T
S
S
Q
Y
V
A
S
A
I
Site 114
Y867
Q
R
R
T
S
S
Q
Y
V
A
S
A
I
A
K
Site 115
Y891
D
V
V
R
P
H
G
Y
A
E
K
G
Y
A
G
Site 116
Y896
H
G
Y
A
E
K
G
Y
A
G
K
A
P
V
L
Site 117
T909
V
L
A
A
P
P
V
T
V
K
D
D
R
T
S
Site 118
T915
V
T
V
K
D
D
R
T
S
S
P
H
S
E
T
Site 119
S916
T
V
K
D
D
R
T
S
S
P
H
S
E
T
Q
Site 120
S917
V
K
D
D
R
T
S
S
P
H
S
E
T
Q
G
Site 121
S920
D
R
T
S
S
P
H
S
E
T
Q
G
W
K
D
Site 122
T935
G
A
Q
W
P
C
V
T
P
P
N
N
H
G
E
Site 123
S962
I
G
P
H
R
K
L
S
T
Q
D
R
P
A
A
Site 124
S973
R
P
A
A
I
H
R
S
S
C
F
S
L
V
Q
Site 125
S974
P
A
A
I
H
R
S
S
C
F
S
L
V
Q
S
Site 126
S977
I
H
R
S
S
C
F
S
L
V
Q
S
S
Q
R
Site 127
S981
S
C
F
S
L
V
Q
S
S
Q
R
D
R
V
S
Site 128
S982
C
F
S
L
V
Q
S
S
Q
R
D
R
V
S
V
Site 129
S988
S
S
Q
R
D
R
V
S
V
G
Q
S
C
G
F
Site 130
S992
D
R
V
S
V
G
Q
S
C
G
F
S
G
K
Q
Site 131
S996
V
G
Q
S
C
G
F
S
G
K
Q
S
T
S
S
Site 132
S1000
C
G
F
S
G
K
Q
S
T
S
S
Q
E
A
S
Site 133
S1002
F
S
G
K
Q
S
T
S
S
Q
E
A
S
S
A
Site 134
S1003
S
G
K
Q
S
T
S
S
Q
E
A
S
S
A
S
Site 135
S1007
S
T
S
S
Q
E
A
S
S
A
S
E
P
R
R
Site 136
S1010
S
Q
E
A
S
S
A
S
E
P
R
R
A
P
D
Site 137
T1019
P
R
R
A
P
D
G
T
D
P
P
P
P
H
T
Site 138
T1026
T
D
P
P
P
P
H
T
S
D
T
Q
A
C
S
Site 139
S1027
D
P
P
P
P
H
T
S
D
T
Q
A
C
S
R
Site 140
T1029
P
P
P
H
T
S
D
T
Q
A
C
S
R
E
L
Site 141
S1040
S
R
E
L
V
N
G
S
V
R
A
P
G
H
G
Site 142
S1050
A
P
G
H
G
E
P
S
H
P
P
G
G
S
G
Site 143
S1056
P
S
H
P
P
G
G
S
G
T
E
S
H
I
L
Site 144
S1060
P
G
G
S
G
T
E
S
H
I
L
L
E
R
E
Site 145
S1071
L
E
R
E
E
K
P
S
V
F
S
T
D
G
N
Site 146
T1075
E
K
P
S
V
F
S
T
D
G
N
E
T
D
S
Site 147
S1082
T
D
G
N
E
T
D
S
I
W
P
P
S
I
F
Site 148
S1087
T
D
S
I
W
P
P
S
I
F
G
P
K
K
K
Site 149
T1107
Q
R
P
V
P
K
D
T
S
L
H
S
A
L
M
Site 150
S1108
R
P
V
P
K
D
T
S
L
H
S
A
L
M
E
Site 151
S1111
P
K
D
T
S
L
H
S
A
L
M
E
A
I
H
Site 152
T1129
G
K
D
R
L
R
K
T
A
E
H
T
G
E
G
Site 153
S1142
E
G
R
P
A
K
L
S
Y
T
E
A
E
G
E
Site 154
Y1143
G
R
P
A
K
L
S
Y
T
E
A
E
G
E
R
Site 155
S1161
L
A
A
I
R
G
H
S
G
T
C
S
L
R
K
Site 156
T1163
A
I
R
G
H
S
G
T
C
S
L
R
K
V
A
Site 157
S1165
R
G
H
S
G
T
C
S
L
R
K
V
A
S
S
Site 158
S1171
C
S
L
R
K
V
A
S
S
A
S
E
E
L
Q
Site 159
S1172
S
L
R
K
V
A
S
S
A
S
E
E
L
Q
S
Site 160
S1174
R
K
V
A
S
S
A
S
E
E
L
Q
S
F
R
Site 161
S1179
S
A
S
E
E
L
Q
S
F
R
D
A
A
L
S
Site 162
S1186
S
F
R
D
A
A
L
S
A
Q
G
S
E
S
P
Site 163
S1190
A
A
L
S
A
Q
G
S
E
S
P
L
L
E
D
Site 164
S1192
L
S
A
Q
G
S
E
S
P
L
L
E
D
L
G
Site 165
S1214
P
P
P
P
P
P
P
S
Q
A
L
S
A
P
R
Site 166
S1218
P
P
P
S
Q
A
L
S
A
P
R
T
A
S
R
Site 167
T1222
Q
A
L
S
A
P
R
T
A
S
R
F
S
T
G
Site 168
S1224
L
S
A
P
R
T
A
S
R
F
S
T
G
T
L
Site 169
S1227
P
R
T
A
S
R
F
S
T
G
T
L
S
N
T
Site 170
T1228
R
T
A
S
R
F
S
T
G
T
L
S
N
T
A
Site 171
T1230
A
S
R
F
S
T
G
T
L
S
N
T
A
D
A
Site 172
S1232
R
F
S
T
G
T
L
S
N
T
A
D
A
R
Q
Site 173
T1249
M
D
A
I
R
S
G
T
G
A
A
R
L
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation