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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASTN2
Full Name:
Astrotactin-2
Alias:
astrotactin 2; KIAA0634
Type:
Unknown function
Mass (Da):
148240
Number AA:
UniProt ID:
O75129
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
L
S
P
G
P
G
S
G
L
R
G
R
P
R
Site 2
S61
A
A
S
R
E
P
D
S
P
C
R
L
K
T
V
Site 3
T67
D
S
P
C
R
L
K
T
V
T
V
S
T
L
P
Site 4
S79
T
L
P
A
L
R
E
S
D
I
G
W
S
G
A
Site 5
S84
R
E
S
D
I
G
W
S
G
A
R
A
G
A
G
Site 6
S110
A
S
P
G
S
P
G
S
A
G
T
A
A
E
S
Site 7
T140
V
Q
D
D
L
D
N
T
E
L
P
F
F
T
L
Site 8
S157
S
G
T
A
A
D
I
S
L
V
H
W
R
Q
Q
Site 9
Y172
W
L
E
N
G
T
L
Y
F
H
V
S
M
S
S
Site 10
S178
L
Y
F
H
V
S
M
S
S
S
G
Q
L
A
Q
Site 11
S180
F
H
V
S
M
S
S
S
G
Q
L
A
Q
A
T
Site 12
Y228
L
V
F
T
V
A
L
Y
A
Q
R
R
W
Q
K
Site 13
S243
R
R
R
I
P
Q
K
S
A
S
T
E
A
T
H
Site 14
S245
R
I
P
Q
K
S
A
S
T
E
A
T
H
E
I
Site 15
T249
K
S
A
S
T
E
A
T
H
E
I
H
Y
I
P
Site 16
S257
H
E
I
H
Y
I
P
S
V
L
L
G
P
Q
A
Site 17
S267
L
G
P
Q
A
R
E
S
F
R
S
S
R
L
Q
Site 18
S270
Q
A
R
E
S
F
R
S
S
R
L
Q
T
H
N
Site 19
S271
A
R
E
S
F
R
S
S
R
L
Q
T
H
N
S
Site 20
T275
F
R
S
S
R
L
Q
T
H
N
S
V
I
G
V
Site 21
S278
S
R
L
Q
T
H
N
S
V
I
G
V
P
I
R
Site 22
T287
I
G
V
P
I
R
E
T
P
I
L
D
D
Y
D
Site 23
Y293
E
T
P
I
L
D
D
Y
D
C
E
E
D
E
E
Site 24
S309
P
R
R
A
N
H
V
S
R
E
D
E
F
G
S
Site 25
S316
S
R
E
D
E
F
G
S
Q
V
T
H
T
L
D
Site 26
T321
F
G
S
Q
V
T
H
T
L
D
S
L
G
H
P
Site 27
S324
Q
V
T
H
T
L
D
S
L
G
H
P
G
E
E
Site 28
S350
A
T
Q
E
T
V
E
S
L
M
Q
K
F
K
E
Site 29
S358
L
M
Q
K
F
K
E
S
F
R
A
N
T
P
I
Site 30
T363
K
E
S
F
R
A
N
T
P
I
E
I
G
Q
L
Site 31
T377
L
Q
P
P
L
R
S
T
S
A
G
K
R
K
R
Site 32
S378
Q
P
P
L
R
S
T
S
A
G
K
R
K
R
R
Site 33
S386
A
G
K
R
K
R
R
S
K
S
R
G
G
I
S
Site 34
S388
K
R
K
R
R
S
K
S
R
G
G
I
S
F
G
Site 35
S393
S
K
S
R
G
G
I
S
F
G
R
A
K
G
T
Site 36
S401
F
G
R
A
K
G
T
S
G
S
E
A
D
D
E
Site 37
S403
R
A
K
G
T
S
G
S
E
A
D
D
E
T
Q
Site 38
T409
G
S
E
A
D
D
E
T
Q
L
T
F
Y
T
E
Site 39
T412
A
D
D
E
T
Q
L
T
F
Y
T
E
Q
Y
R
Site 40
Y414
D
E
T
Q
L
T
F
Y
T
E
Q
Y
R
S
R
Site 41
T415
E
T
Q
L
T
F
Y
T
E
Q
Y
R
S
R
R
Site 42
Y418
L
T
F
Y
T
E
Q
Y
R
S
R
R
R
S
K
Site 43
S420
F
Y
T
E
Q
Y
R
S
R
R
R
S
K
G
L
Site 44
S424
Q
Y
R
S
R
R
R
S
K
G
L
L
K
S
P
Site 45
S430
R
S
K
G
L
L
K
S
P
V
N
K
T
A
L
Site 46
S481
D
G
S
S
F
V
V
S
E
G
S
Y
L
D
I
Site 47
S484
S
F
V
V
S
E
G
S
Y
L
D
I
S
D
W
Site 48
S489
E
G
S
Y
L
D
I
S
D
W
L
N
P
A
K
Site 49
Y500
N
P
A
K
L
S
L
Y
Y
Q
I
N
A
T
S
Site 50
T519
D
L
C
G
Q
R
T
T
D
A
C
E
Q
L
C
Site 51
T530
E
Q
L
C
D
P
E
T
G
E
C
S
C
H
E
Site 52
Y539
E
C
S
C
H
E
G
Y
A
P
D
P
V
H
R
Site 53
T564
S
E
G
P
W
P
Y
T
T
L
E
R
G
Y
D
Site 54
T565
E
G
P
W
P
Y
T
T
L
E
R
G
Y
D
L
Site 55
Y570
Y
T
T
L
E
R
G
Y
D
L
V
T
G
E
Q
Site 56
T574
E
R
G
Y
D
L
V
T
G
E
Q
A
P
E
K
Site 57
S585
A
P
E
K
I
L
R
S
T
F
S
L
G
Q
G
Site 58
T586
P
E
K
I
L
R
S
T
F
S
L
G
Q
G
L
Site 59
T618
N
P
L
A
S
C
K
T
D
V
L
V
T
E
D
Site 60
S636
V
R
E
E
A
M
L
S
T
Y
F
E
T
I
N
Site 61
Y638
E
E
A
M
L
S
T
Y
F
E
T
I
N
D
L
Site 62
S647
E
T
I
N
D
L
L
S
S
F
G
P
V
R
D
Site 63
S656
F
G
P
V
R
D
C
S
R
N
N
G
G
C
T
Site 64
S670
T
R
N
F
K
C
V
S
D
R
Q
V
D
S
S
Site 65
S677
S
D
R
Q
V
D
S
S
G
C
V
C
P
E
E
Site 66
S692
L
K
P
M
K
D
G
S
G
C
Y
D
H
S
K
Site 67
Y695
M
K
D
G
S
G
C
Y
D
H
S
K
G
I
D
Site 68
Y724
Q
Q
T
L
P
L
P
Y
D
A
T
S
S
T
I
Site 69
S754
G
K
S
C
L
M
L
S
D
V
C
E
G
P
K
Site 70
S767
P
K
C
L
K
P
D
S
K
F
N
D
T
L
F
Site 71
T772
P
D
S
K
F
N
D
T
L
F
G
E
M
L
H
Site 72
Y781
F
G
E
M
L
H
G
Y
N
N
R
T
Q
H
V
Site 73
S830
E
Q
C
R
G
V
L
S
E
P
L
P
D
L
Q
Site 74
Y845
L
L
T
G
D
I
R
Y
D
E
A
M
G
Y
P
Site 75
Y851
R
Y
D
E
A
M
G
Y
P
M
V
Q
Q
W
R
Site 76
S861
V
Q
Q
W
R
V
R
S
N
L
Y
R
V
K
L
Site 77
T885
T
N
V
L
K
I
L
T
K
E
S
S
R
E
E
Site 78
S888
L
K
I
L
T
K
E
S
S
R
E
E
L
L
S
Site 79
S889
K
I
L
T
K
E
S
S
R
E
E
L
L
S
F
Site 80
S895
S
S
R
E
E
L
L
S
F
I
Q
H
Y
G
S
Site 81
Y904
I
Q
H
Y
G
S
H
Y
I
A
E
A
L
Y
G
Site 82
S948
G
S
K
K
E
L
K
S
M
P
F
I
T
Y
L
Site 83
S971
L
S
D
D
Q
L
I
S
G
V
E
I
R
C
E
Site 84
S985
E
E
K
G
R
C
P
S
T
C
H
L
C
R
R
Site 85
T986
E
K
G
R
C
P
S
T
C
H
L
C
R
R
P
Site 86
S999
R
P
G
K
E
Q
L
S
P
T
P
V
L
L
E
Site 87
T1001
G
K
E
Q
L
S
P
T
P
V
L
L
E
I
N
Site 88
S1028
G
T
K
E
A
F
K
S
A
L
M
S
S
Y
W
Site 89
S1032
A
F
K
S
A
L
M
S
S
Y
W
C
S
G
K
Site 90
S1033
F
K
S
A
L
M
S
S
Y
W
C
S
G
K
G
Site 91
Y1034
K
S
A
L
M
S
S
Y
W
C
S
G
K
G
D
Site 92
S1073
L
Q
P
V
L
R
L
S
P
T
V
E
P
S
S
Site 93
S1080
S
P
T
V
E
P
S
S
T
V
V
S
L
E
W
Site 94
S1084
E
P
S
S
T
V
V
S
L
E
W
V
D
V
Q
Site 95
S1099
P
A
I
G
T
K
V
S
D
Y
I
L
Q
H
K
Site 96
Y1101
I
G
T
K
V
S
D
Y
I
L
Q
H
K
K
V
Site 97
Y1111
Q
H
K
K
V
D
E
Y
T
D
T
D
L
Y
T
Site 98
T1112
H
K
K
V
D
E
Y
T
D
T
D
L
Y
T
G
Site 99
T1114
K
V
D
E
Y
T
D
T
D
L
Y
T
G
E
F
Site 100
Y1117
E
Y
T
D
T
D
L
Y
T
G
E
F
L
S
F
Site 101
T1118
Y
T
D
T
D
L
Y
T
G
E
F
L
S
F
A
Site 102
S1123
L
Y
T
G
E
F
L
S
F
A
D
D
L
L
S
Site 103
S1142
S
C
V
A
A
G
R
S
H
G
E
V
P
E
V
Site 104
Y1170
G
L
Y
K
F
T
L
Y
A
V
D
T
R
G
R
Site 105
T1174
F
T
L
Y
A
V
D
T
R
G
R
H
S
E
L
Site 106
S1179
V
D
T
R
G
R
H
S
E
L
S
T
V
T
L
Site 107
S1182
R
G
R
H
S
E
L
S
T
V
T
L
R
T
A
Site 108
T1183
G
R
H
S
E
L
S
T
V
T
L
R
T
A
C
Site 109
Y1206
E
E
I
A
D
K
I
Y
N
L
Y
N
G
Y
T
Site 110
Y1209
A
D
K
I
Y
N
L
Y
N
G
Y
T
S
G
K
Site 111
Y1240
L
F
R
V
Q
H
H
Y
N
S
H
Y
E
K
F
Site 112
Y1244
Q
H
H
Y
N
S
H
Y
E
K
F
G
D
F
V
Site 113
S1254
F
G
D
F
V
W
R
S
E
D
E
L
G
P
R
Site 114
S1274
L
R
R
L
E
R
V
S
S
H
C
S
S
L
L
Site 115
S1275
R
R
L
E
R
V
S
S
H
C
S
S
L
L
R
Site 116
S1278
E
R
V
S
S
H
C
S
S
L
L
R
S
A
Y
Site 117
S1279
R
V
S
S
H
C
S
S
L
L
R
S
A
Y
I
Site 118
S1283
H
C
S
S
L
L
R
S
A
Y
I
Q
S
R
V
Site 119
Y1285
S
S
L
L
R
S
A
Y
I
Q
S
R
V
E
T
Site 120
T1292
Y
I
Q
S
R
V
E
T
V
P
Y
L
F
C
R
Site 121
Y1295
S
R
V
E
T
V
P
Y
L
F
C
R
S
E
E
Site 122
S1300
V
P
Y
L
F
C
R
S
E
E
V
R
P
A
G
Site 123
T1332
M
V
S
M
A
R
N
T
Y
G
E
S
K
G
R
Site 124
Y1333
V
S
M
A
R
N
T
Y
G
E
S
K
G
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation