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Updated November 2019
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Protein Info
Short Name:
ZBED4
Full Name:
Zinc finger BED domain-containing protein 4
Alias:
KIAA0637; zinc finger BED domain containing protein 4; zinc finger, BED-type containing 4
Type:
DNA binding protein
Mass (Da):
130308
Number AA:
1171
UniProt ID:
O75132
International Prot ID:
IPI00006610
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0046983
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
K
E
D
G
D
F
V
S
D
K
I
K
F
K
I
Site 2
S36
D
D
G
I
P
P
D
S
L
E
R
M
D
F
K
Site 3
S44
L
E
R
M
D
F
K
S
E
Q
E
D
M
K
Q
Site 4
S67
G
L
G
G
T
G
C
S
C
K
P
P
G
K
Y
Site 5
Y74
S
C
K
P
P
G
K
Y
L
S
A
E
S
E
D
Site 6
S76
K
P
P
G
K
Y
L
S
A
E
S
E
D
D
Y
Site 7
Y83
S
A
E
S
E
D
D
Y
G
A
L
F
S
Q
Y
Site 8
S88
D
D
Y
G
A
L
F
S
Q
Y
S
S
T
L
Y
Site 9
Y90
Y
G
A
L
F
S
Q
Y
S
S
T
L
Y
D
V
Site 10
Y95
S
Q
Y
S
S
T
L
Y
D
V
A
M
E
A
V
Site 11
S105
A
M
E
A
V
T
Q
S
L
L
S
S
R
N
M
Site 12
S108
A
V
T
Q
S
L
L
S
S
R
N
M
S
S
R
Site 13
S109
V
T
Q
S
L
L
S
S
R
N
M
S
S
R
K
Site 14
S113
L
L
S
S
R
N
M
S
S
R
K
K
S
P
A
Site 15
S114
L
S
S
R
N
M
S
S
R
K
K
S
P
A
W
Site 16
S118
N
M
S
S
R
K
K
S
P
A
W
K
H
F
F
Site 17
S127
A
W
K
H
F
F
I
S
P
R
D
S
T
K
A
Site 18
Y138
S
T
K
A
I
C
M
Y
C
V
K
E
F
S
R
Site 19
S153
G
K
N
E
K
D
L
S
T
S
C
L
M
R
H
Site 20
T154
K
N
E
K
D
L
S
T
S
C
L
M
R
H
V
Site 21
T167
H
V
R
R
A
H
P
T
V
L
I
Q
E
N
G
Site 22
S177
I
Q
E
N
G
S
V
S
A
V
S
S
F
P
S
Site 23
S180
N
G
S
V
S
A
V
S
S
F
P
S
P
S
L
Site 24
S186
V
S
S
F
P
S
P
S
L
L
L
P
P
Q
P
Site 25
S214
K
L
V
Q
K
V
A
S
K
I
P
S
P
D
R
Site 26
S218
K
V
A
S
K
I
P
S
P
D
R
I
T
E
E
Site 27
T223
I
P
S
P
D
R
I
T
E
E
S
V
S
V
V
Site 28
S226
P
D
R
I
T
E
E
S
V
S
V
V
S
S
E
Site 29
S228
R
I
T
E
E
S
V
S
V
V
S
S
E
E
I
Site 30
S231
E
E
S
V
S
V
V
S
S
E
E
I
S
S
D
Site 31
S232
E
S
V
S
V
V
S
S
E
E
I
S
S
D
M
Site 32
S236
V
V
S
S
E
E
I
S
S
D
M
S
V
S
E
Site 33
S237
V
S
S
E
E
I
S
S
D
M
S
V
S
E
K
Site 34
S240
E
E
I
S
S
D
M
S
V
S
E
K
C
G
R
Site 35
S242
I
S
S
D
M
S
V
S
E
K
C
G
R
E
E
Site 36
S255
E
E
A
L
V
G
S
S
P
H
L
P
A
L
H
Site 37
Y263
P
H
L
P
A
L
H
Y
D
E
P
A
E
N
L
Site 38
S274
A
E
N
L
A
E
K
S
L
P
L
P
K
S
T
Site 39
S280
K
S
L
P
L
P
K
S
T
S
G
S
R
R
R
Site 40
S282
L
P
L
P
K
S
T
S
G
S
R
R
R
S
A
Site 41
S284
L
P
K
S
T
S
G
S
R
R
R
S
A
V
W
Site 42
S288
T
S
G
S
R
R
R
S
A
V
W
K
H
F
Y
Site 43
Y295
S
A
V
W
K
H
F
Y
L
S
P
L
D
N
S
Site 44
S297
V
W
K
H
F
Y
L
S
P
L
D
N
S
K
A
Site 45
T324
K
N
G
K
D
L
G
T
S
C
L
I
R
H
M
Site 46
T346
V
L
Q
E
N
G
G
T
G
I
P
P
L
Y
S
Site 47
S361
T
P
P
T
L
L
P
S
L
L
P
P
E
G
E
Site 48
S370
L
P
P
E
G
E
L
S
S
V
S
S
S
P
V
Site 49
S371
P
P
E
G
E
L
S
S
V
S
S
S
P
V
K
Site 50
S373
E
G
E
L
S
S
V
S
S
S
P
V
K
P
V
Site 51
S374
G
E
L
S
S
V
S
S
S
P
V
K
P
V
R
Site 52
S375
E
L
S
S
V
S
S
S
P
V
K
P
V
R
E
Site 53
S383
P
V
K
P
V
R
E
S
P
S
A
S
S
S
P
Site 54
S385
K
P
V
R
E
S
P
S
A
S
S
S
P
D
R
Site 55
S387
V
R
E
S
P
S
A
S
S
S
P
D
R
L
T
Site 56
S388
R
E
S
P
S
A
S
S
S
P
D
R
L
T
E
Site 57
S389
E
S
P
S
A
S
S
S
P
D
R
L
T
E
D
Site 58
T394
S
S
S
P
D
R
L
T
E
D
L
Q
S
H
L
Site 59
S399
R
L
T
E
D
L
Q
S
H
L
N
P
G
D
G
Site 60
S417
D
V
A
A
F
S
S
S
D
D
V
G
E
A
S
Site 61
S424
S
D
D
V
G
E
A
S
A
S
S
P
E
K
Q
Site 62
S426
D
V
G
E
A
S
A
S
S
P
E
K
Q
Q
A
Site 63
S427
V
G
E
A
S
A
S
S
P
E
K
Q
Q
A
D
Site 64
S437
K
Q
Q
A
D
G
L
S
P
R
L
F
E
S
G
Site 65
S443
L
S
P
R
L
F
E
S
G
A
I
F
Q
Q
N
Site 66
S459
K
V
M
K
R
L
K
S
E
V
W
H
H
F
S
Site 67
S466
S
E
V
W
H
H
F
S
L
A
P
M
D
S
L
Site 68
S472
F
S
L
A
P
M
D
S
L
K
A
E
C
R
Y
Site 69
S485
R
Y
C
G
C
A
I
S
R
G
K
K
G
D
V
Site 70
T494
G
K
K
G
D
V
G
T
S
C
L
M
R
H
L
Site 71
Y502
S
C
L
M
R
H
L
Y
R
R
H
P
E
V
V
Site 72
S511
R
H
P
E
V
V
G
S
Q
K
G
F
L
G
A
Site 73
S519
Q
K
G
F
L
G
A
S
L
A
N
S
P
Y
A
Site 74
S523
L
G
A
S
L
A
N
S
P
Y
A
T
L
A
S
Site 75
T527
L
A
N
S
P
Y
A
T
L
A
S
A
E
S
S
Site 76
S530
S
P
Y
A
T
L
A
S
A
E
S
S
S
S
K
Site 77
S533
A
T
L
A
S
A
E
S
S
S
S
K
L
T
D
Site 78
S534
T
L
A
S
A
E
S
S
S
S
K
L
T
D
L
Site 79
S536
A
S
A
E
S
S
S
S
K
L
T
D
L
P
T
Site 80
T539
E
S
S
S
S
K
L
T
D
L
P
T
V
V
T
Site 81
T543
S
K
L
T
D
L
P
T
V
V
T
K
N
N
Q
Site 82
T546
T
D
L
P
T
V
V
T
K
N
N
Q
V
M
F
Site 83
S557
Q
V
M
F
P
V
N
S
K
K
T
S
K
L
W
Site 84
S561
P
V
N
S
K
K
T
S
K
L
W
N
H
F
S
Site 85
S568
S
K
L
W
N
H
F
S
I
C
S
A
D
S
T
Site 86
S571
W
N
H
F
S
I
C
S
A
D
S
T
K
V
V
Site 87
S574
F
S
I
C
S
A
D
S
T
K
V
V
C
L
H
Site 88
T575
S
I
C
S
A
D
S
T
K
V
V
C
L
H
C
Site 89
S587
L
H
C
G
R
T
I
S
R
G
K
K
P
T
N
Site 90
T593
I
S
R
G
K
K
P
T
N
L
G
T
S
C
L
Site 91
S609
R
H
L
Q
R
F
H
S
N
V
L
K
T
E
V
Site 92
T614
F
H
S
N
V
L
K
T
E
V
S
E
T
A
R
Site 93
S617
N
V
L
K
T
E
V
S
E
T
A
R
P
S
S
Site 94
T619
L
K
T
E
V
S
E
T
A
R
P
S
S
P
D
Site 95
S623
V
S
E
T
A
R
P
S
S
P
D
T
R
V
P
Site 96
S624
S
E
T
A
R
P
S
S
P
D
T
R
V
P
R
Site 97
T627
A
R
P
S
S
P
D
T
R
V
P
R
G
T
E
Site 98
T633
D
T
R
V
P
R
G
T
E
L
S
G
A
S
S
Site 99
S636
V
P
R
G
T
E
L
S
G
A
S
S
F
D
D
Site 100
S640
T
E
L
S
G
A
S
S
F
D
D
T
N
E
K
Site 101
T644
G
A
S
S
F
D
D
T
N
E
K
F
Y
D
S
Site 102
Y687
G
F
N
R
L
L
E
Y
L
K
P
Q
Y
S
L
Site 103
Y692
L
E
Y
L
K
P
Q
Y
S
L
P
A
P
S
Y
Site 104
S693
E
Y
L
K
P
Q
Y
S
L
P
A
P
S
Y
F
Site 105
S698
Q
Y
S
L
P
A
P
S
Y
F
S
R
T
A
I
Site 106
Y699
Y
S
L
P
A
P
S
Y
F
S
R
T
A
I
P
Site 107
T703
A
P
S
Y
F
S
R
T
A
I
P
G
M
Y
D
Site 108
Y709
R
T
A
I
P
G
M
Y
D
N
V
K
Q
I
I
Site 109
S725
S
H
L
K
E
A
E
S
G
V
I
H
F
T
S
Site 110
Y743
M
S
N
Q
T
R
E
Y
L
T
L
T
A
H
W
Site 111
T747
T
R
E
Y
L
T
L
T
A
H
W
V
S
F
E
Site 112
S752
T
L
T
A
H
W
V
S
F
E
S
P
A
R
P
Site 113
S755
A
H
W
V
S
F
E
S
P
A
R
P
R
C
D
Site 114
Y779
V
S
Q
V
D
C
D
Y
S
G
N
S
I
Q
K
Site 115
S780
S
Q
V
D
C
D
Y
S
G
N
S
I
Q
K
Q
Site 116
T816
D
N
A
S
I
G
K
T
L
N
E
G
E
H
S
Site 117
S823
T
L
N
E
G
E
H
S
S
V
Q
C
F
S
H
Site 118
S824
L
N
E
G
E
H
S
S
V
Q
C
F
S
H
T
Site 119
S837
H
T
V
N
L
I
V
S
E
A
I
K
S
Q
R
Site 120
S842
I
V
S
E
A
I
K
S
Q
R
M
V
Q
N
L
Site 121
S863
I
C
E
R
V
H
R
S
P
K
A
K
E
K
L
Site 122
Y877
L
A
E
L
Q
R
E
Y
A
L
P
Q
H
H
L
Site 123
T894
D
V
P
S
K
W
S
T
S
F
H
M
L
E
R
Site 124
S895
V
P
S
K
W
S
T
S
F
H
M
L
E
R
L
Site 125
S944
L
K
P
F
E
A
A
S
R
E
M
S
T
Q
M
Site 126
S948
E
A
A
S
R
E
M
S
T
Q
M
S
T
L
S
Site 127
T949
A
A
S
R
E
M
S
T
Q
M
S
T
L
S
Q
Site 128
S952
R
E
M
S
T
Q
M
S
T
L
S
Q
V
I
P
Site 129
T953
E
M
S
T
Q
M
S
T
L
S
Q
V
I
P
M
Site 130
T980
E
E
T
M
G
I
D
T
M
L
R
S
L
K
E
Site 131
S991
S
L
K
E
A
M
V
S
R
L
S
A
T
L
H
Site 132
S994
E
A
M
V
S
R
L
S
A
T
L
H
D
P
R
Site 133
T1006
D
P
R
Y
V
F
A
T
L
L
D
P
R
Y
K
Site 134
Y1012
A
T
L
L
D
P
R
Y
K
A
S
L
F
T
E
Site 135
S1015
L
D
P
R
Y
K
A
S
L
F
T
E
E
E
A
Site 136
Y1025
T
E
E
E
A
E
Q
Y
K
Q
D
L
I
R
E
Site 137
S1038
R
E
L
E
L
M
N
S
T
S
E
D
V
A
A
Site 138
S1040
L
E
L
M
N
S
T
S
E
D
V
A
A
S
H
Site 139
S1046
T
S
E
D
V
A
A
S
H
R
C
D
A
G
S
Site 140
S1053
S
H
R
C
D
A
G
S
P
S
K
D
S
A
A
Site 141
S1058
A
G
S
P
S
K
D
S
A
A
E
E
N
L
W
Site 142
S1066
A
A
E
E
N
L
W
S
L
V
A
K
V
K
K
Site 143
S1110
Y
W
N
L
K
K
A
S
W
P
G
L
S
A
L
Site 144
S1131
C
P
P
S
I
V
P
S
E
K
L
F
N
T
P
Site 145
T1137
P
S
E
K
L
F
N
T
P
T
E
N
G
S
L
Site 146
T1139
E
K
L
F
N
T
P
T
E
N
G
S
L
G
Q
Site 147
S1143
N
T
P
T
E
N
G
S
L
G
Q
S
R
L
M
Site 148
S1147
E
N
G
S
L
G
Q
S
R
L
M
M
E
H
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation