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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIP1R
Full Name:
Huntingtin-interacting protein 1-related protein
Alias:
FLJ14000; Hip 12; HIP12; Hip1-related; HIP3; Huntingtin interacting protein 1 related; Huntingtin-interacting protein 12; ILWEQ; KIAA0655
Type:
Vesicle protein
Mass (Da):
119388
Number AA:
1068
UniProt ID:
O75146
International Prot ID:
IPI00024417
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030665
GO:0005905
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006898
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
N
V
P
A
R
V
L
S
R
R
P
G
H
S
L
Site 2
S19
L
S
R
R
P
G
H
S
L
E
A
E
R
E
Q
Site 3
T30
E
R
E
Q
F
D
K
T
Q
A
I
S
I
S
K
Site 4
S34
F
D
K
T
Q
A
I
S
I
S
K
A
I
N
T
Site 5
T58
A
R
R
I
I
L
G
T
H
H
E
K
G
A
F
Site 6
Y126
W
G
H
L
H
D
R
Y
G
Q
L
V
N
V
Y
Site 7
S142
K
L
L
L
T
K
I
S
F
H
L
K
H
P
Q
Site 8
S190
M
D
C
E
L
K
L
S
E
S
V
F
R
Q
L
Site 9
S192
C
E
L
K
L
S
E
S
V
F
R
Q
L
N
T
Site 10
Y227
I
Q
D
C
S
H
L
Y
H
Y
T
V
K
L
L
Site 11
Y229
D
C
S
H
L
Y
H
Y
T
V
K
L
L
F
K
Site 12
S268
R
N
F
F
R
R
A
S
D
M
L
Y
F
K
R
Site 13
Y272
R
R
A
S
D
M
L
Y
F
K
R
L
I
Q
I
Site 14
S293
P
P
N
F
L
R
A
S
A
L
A
E
H
I
K
Site 15
T323
E
N
L
I
E
I
S
T
G
P
P
A
G
E
P
Site 16
T340
V
A
D
L
F
D
Q
T
F
G
P
P
N
G
S
Site 17
S347
T
F
G
P
P
N
G
S
V
K
D
D
R
D
L
Site 18
S358
D
R
D
L
Q
I
E
S
L
K
R
E
V
E
M
Site 19
S368
R
E
V
E
M
L
R
S
E
L
E
K
I
K
L
Site 20
Y380
I
K
L
E
A
Q
R
Y
I
A
Q
L
K
S
Q
Site 21
S386
R
Y
I
A
Q
L
K
S
Q
V
N
A
L
E
G
Site 22
S429
A
Q
L
E
G
E
R
S
Q
G
L
R
E
E
A
Site 23
S441
E
E
A
E
R
K
A
S
A
T
E
A
R
Y
N
Site 24
T443
A
E
R
K
A
S
A
T
E
A
R
Y
N
K
L
Site 25
S455
N
K
L
K
E
K
H
S
E
L
V
H
V
H
A
Site 26
T471
L
L
R
K
N
A
D
T
A
K
Q
L
T
V
T
Site 27
T476
A
D
T
A
K
Q
L
T
V
T
Q
Q
S
Q
E
Site 28
S503
V
E
Q
V
K
R
E
S
E
L
K
L
E
E
K
Site 29
S511
E
L
K
L
E
E
K
S
D
Q
L
E
K
L
K
Site 30
S536
A
R
A
Q
E
A
L
S
H
T
E
Q
S
K
S
Site 31
S541
A
L
S
H
T
E
Q
S
K
S
E
L
S
S
R
Site 32
S543
S
H
T
E
Q
S
K
S
E
L
S
S
R
L
D
Site 33
S546
E
Q
S
K
S
E
L
S
S
R
L
D
T
L
S
Site 34
S547
Q
S
K
S
E
L
S
S
R
L
D
T
L
S
A
Site 35
T551
E
L
S
S
R
L
D
T
L
S
A
E
K
D
A
Site 36
S553
S
S
R
L
D
T
L
S
A
E
K
D
A
L
S
Site 37
S560
S
A
E
K
D
A
L
S
G
A
V
R
Q
R
E
Site 38
S575
A
D
L
L
A
A
Q
S
L
V
R
E
T
E
A
Site 39
T580
A
Q
S
L
V
R
E
T
E
A
A
L
S
R
E
Site 40
S585
R
E
T
E
A
A
L
S
R
E
Q
Q
R
S
S
Site 41
S591
L
S
R
E
Q
Q
R
S
S
Q
E
Q
G
E
L
Site 42
S592
S
R
E
Q
Q
R
S
S
Q
E
Q
G
E
L
Q
Site 43
S607
G
R
L
A
E
R
E
S
Q
E
Q
G
L
R
Q
Site 44
S640
G
I
L
Q
D
A
V
S
K
L
D
D
P
L
H
Site 45
T651
D
P
L
H
L
R
C
T
S
S
P
D
Y
L
V
Site 46
S652
P
L
H
L
R
C
T
S
S
P
D
Y
L
V
S
Site 47
S653
L
H
L
R
C
T
S
S
P
D
Y
L
V
S
R
Site 48
Y656
R
C
T
S
S
P
D
Y
L
V
S
R
A
Q
E
Site 49
S659
S
S
P
D
Y
L
V
S
R
A
Q
E
A
L
D
Site 50
S669
Q
E
A
L
D
A
V
S
T
L
E
E
G
H
A
Site 51
T724
P
A
D
R
L
I
D
T
C
R
E
C
G
A
R
Site 52
S751
A
L
R
H
M
Q
A
S
L
V
R
T
P
L
Q
Site 53
S771
G
Q
E
L
K
P
K
S
L
D
V
R
Q
E
E
Site 54
S812
M
N
Q
A
R
H
A
S
S
G
V
K
L
E
V
Site 55
T839
K
A
I
R
L
L
V
T
T
S
T
S
L
Q
K
Site 56
T840
A
I
R
L
L
V
T
T
S
T
S
L
Q
K
E
Site 57
T842
R
L
L
V
T
T
S
T
S
L
Q
K
E
I
V
Site 58
S851
L
Q
K
E
I
V
E
S
G
R
G
A
A
T
Q
Site 59
T869
Y
A
K
N
S
R
W
T
E
G
L
I
S
A
S
Site 60
S874
R
W
T
E
G
L
I
S
A
S
K
A
V
G
W
Site 61
S929
K
V
K
A
N
K
H
S
P
H
L
S
R
L
Q
Site 62
S933
N
K
H
S
P
H
L
S
R
L
Q
E
C
S
R
Site 63
S939
L
S
R
L
Q
E
C
S
R
T
V
N
E
R
A
Site 64
T941
R
L
Q
E
C
S
R
T
V
N
E
R
A
A
N
Site 65
T965
E
Q
I
E
D
R
D
T
M
D
F
S
G
L
S
Site 66
S969
D
R
D
T
M
D
F
S
G
L
S
L
I
K
L
Site 67
T993
R
V
L
E
L
E
K
T
L
E
A
E
R
M
R
Site 68
Y1009
G
E
L
R
K
Q
H
Y
V
L
A
G
A
S
G
Site 69
S1015
H
Y
V
L
A
G
A
S
G
S
P
G
E
E
V
Site 70
S1017
V
L
A
G
A
S
G
S
P
G
E
E
V
A
I
Site 71
S1027
E
E
V
A
I
R
P
S
T
A
P
R
S
V
T
Site 72
T1028
E
V
A
I
R
P
S
T
A
P
R
S
V
T
T
Site 73
S1032
R
P
S
T
A
P
R
S
V
T
T
K
K
P
P
Site 74
T1034
S
T
A
P
R
S
V
T
T
K
K
P
P
L
A
Site 75
S1045
P
P
L
A
Q
K
P
S
V
A
P
R
Q
D
H
Site 76
Y1061
L
D
K
K
D
G
I
Y
P
A
Q
L
V
N
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation