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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF40
Full Name:
E3 ubiquitin-protein ligase BRE1B
Alias:
95 kDa retinoblastoma protein binding; 95 kDa retinoblastoma-associated; BRE1 E3 ubiquitin ligase B; BRE1B; BRE1-B; KIAA0661; Rb-associated; RBP95; RING finger 40; Ring finger protein 40; STARING; Ubiquitin-protein ligase BRE1B
Type:
Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system
Mass (Da):
113678
Number AA:
1001
UniProt ID:
O75150
International Prot ID:
IPI00162563
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
GO:0019717
Uniprot
OncoNet
Molecular Function:
GO:0042803
GO:0031625
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0033523
GO:0010390
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
R
A
A
G
D
G
G
S
G
P
P
E
K
K
L
Site 2
S23
G
P
P
E
K
K
L
S
R
E
E
K
T
T
T
Site 3
T29
L
S
R
E
E
K
T
T
T
T
L
I
E
P
I
Site 4
T30
S
R
E
E
K
T
T
T
T
L
I
E
P
I
R
Site 5
S42
P
I
R
L
G
G
I
S
S
T
E
E
M
D
L
Site 6
S43
I
R
L
G
G
I
S
S
T
E
E
M
D
L
K
Site 7
T86
K
L
E
K
R
Q
A
T
D
D
A
T
L
L
I
Site 8
T90
R
Q
A
T
D
D
A
T
L
L
I
V
N
R
Y
Site 9
T104
Y
W
A
Q
L
D
E
T
V
E
A
L
L
R
C
Site 10
S114
A
L
L
R
C
H
E
S
Q
G
E
L
S
S
A
Site 11
S120
E
S
Q
G
E
L
S
S
A
P
E
A
P
G
T
Site 12
T127
S
A
P
E
A
P
G
T
Q
E
G
P
T
C
D
Site 13
T132
P
G
T
Q
E
G
P
T
C
D
G
T
P
L
P
Site 14
T136
E
G
P
T
C
D
G
T
P
L
P
E
P
G
T
Site 15
S144
P
L
P
E
P
G
T
S
E
L
R
D
P
L
L
Site 16
S199
V
S
R
V
V
E
A
S
D
R
L
Q
R
R
V
Site 17
Y214
E
E
L
C
Q
R
V
Y
S
R
G
D
S
E
P
Site 18
S215
E
L
C
Q
R
V
Y
S
R
G
D
S
E
P
L
Site 19
S219
R
V
Y
S
R
G
D
S
E
P
L
S
E
A
A
Site 20
S223
R
G
D
S
E
P
L
S
E
A
A
Q
A
H
T
Site 21
T245
R
R
L
Q
D
L
A
T
Q
L
Q
E
K
H
H
Site 22
S255
Q
E
K
H
H
R
I
S
L
E
Y
S
E
L
Q
Site 23
S259
H
R
I
S
L
E
Y
S
E
L
Q
D
K
V
T
Site 24
T266
S
E
L
Q
D
K
V
T
S
A
E
T
K
V
L
Site 25
T278
K
V
L
E
M
E
T
T
V
E
D
L
Q
W
D
Site 26
S309
E
A
L
E
Q
L
N
S
G
Y
Y
V
S
G
S
Site 27
Y311
L
E
Q
L
N
S
G
Y
Y
V
S
G
S
S
S
Site 28
Y312
E
Q
L
N
S
G
Y
Y
V
S
G
S
S
S
G
Site 29
S314
L
N
S
G
Y
Y
V
S
G
S
S
S
G
F
Q
Site 30
S316
S
G
Y
Y
V
S
G
S
S
S
G
F
Q
G
G
Site 31
S318
Y
Y
V
S
G
S
S
S
G
F
Q
G
G
Q
I
Site 32
S328
Q
G
G
Q
I
T
L
S
M
Q
K
F
E
M
L
Site 33
S348
E
N
Q
E
L
A
N
S
R
M
A
E
L
E
K
Site 34
T385
P
E
E
V
V
R
E
T
G
E
Y
R
M
L
Q
Site 35
Y388
V
V
R
E
T
G
E
Y
R
M
L
Q
A
Q
F
Site 36
S396
R
M
L
Q
A
Q
F
S
L
L
Y
N
E
S
L
Site 37
Y399
Q
A
Q
F
S
L
L
Y
N
E
S
L
Q
V
K
Site 38
S402
F
S
L
L
Y
N
E
S
L
Q
V
K
T
Q
L
Site 39
S422
L
L
L
A
T
K
N
S
H
L
R
H
I
E
H
Site 40
S432
R
H
I
E
H
M
E
S
D
E
L
G
L
Q
K
Site 41
T451
E
V
I
Q
L
E
D
T
L
A
Q
V
R
K
E
Site 42
Y459
L
A
Q
V
R
K
E
Y
E
M
L
R
I
E
F
Site 43
Y504
L
K
G
D
A
Q
R
Y
K
R
K
L
R
E
V
Site 44
S523
G
K
L
R
A
Q
A
S
G
S
A
H
S
T
P
Site 45
S525
L
R
A
Q
A
S
G
S
A
H
S
T
P
N
L
Site 46
S528
Q
A
S
G
S
A
H
S
T
P
N
L
G
H
P
Site 47
T529
A
S
G
S
A
H
S
T
P
N
L
G
H
P
E
Site 48
S538
N
L
G
H
P
E
D
S
G
V
S
A
P
A
P
Site 49
S556
E
G
G
P
G
P
V
S
T
P
D
N
R
K
E
Site 50
T557
G
G
P
G
P
V
S
T
P
D
N
R
K
E
M
Site 51
T571
M
A
P
V
P
G
T
T
T
T
T
T
S
V
K
Site 52
T574
V
P
G
T
T
T
T
T
T
S
V
K
K
E
E
Site 53
S576
G
T
T
T
T
T
T
S
V
K
K
E
E
L
V
Site 54
S585
K
K
E
E
L
V
P
S
E
E
D
F
Q
G
I
Site 55
T593
E
E
D
F
Q
G
I
T
P
G
A
Q
G
P
S
Site 56
S600
T
P
G
A
Q
G
P
S
S
R
G
R
E
P
E
Site 57
S601
P
G
A
Q
G
P
S
S
R
G
R
E
P
E
A
Site 58
S621
L
R
E
R
E
G
P
S
L
G
P
P
P
V
A
Site 59
S629
L
G
P
P
P
V
A
S
A
L
S
R
A
D
R
Site 60
T644
E
K
A
K
V
E
E
T
K
R
K
E
S
E
L
Site 61
S649
E
E
T
K
R
K
E
S
E
L
L
K
G
L
R
Site 62
Y676
M
K
L
L
L
D
M
Y
K
S
A
P
K
E
Q
Site 63
S678
L
L
L
D
M
Y
K
S
A
P
K
E
Q
R
D
Site 64
S718
E
E
R
D
R
R
E
S
K
K
I
A
D
E
D
Site 65
S756
Q
E
E
E
A
L
L
S
E
M
D
V
T
G
Q
Site 66
T761
L
L
S
E
M
D
V
T
G
Q
A
F
E
D
M
Site 67
S791
D
A
N
F
K
L
M
S
E
R
I
K
A
N
Q
Site 68
S819
E
Q
V
L
G
L
K
S
Q
V
D
A
Q
L
L
Site 69
T827
Q
V
D
A
Q
L
L
T
V
Q
K
L
E
E
K
Site 70
S841
K
E
R
A
L
Q
G
S
L
G
G
V
E
K
E
Site 71
T850
G
G
V
E
K
E
L
T
L
R
S
Q
A
L
E
Site 72
S853
E
K
E
L
T
L
R
S
Q
A
L
E
L
N
K
Site 73
T882
V
Q
L
E
H
V
Q
T
R
L
R
E
I
Q
P
Site 74
S902
R
A
A
R
E
K
E
S
F
N
L
K
R
A
Q
Site 75
S913
K
R
A
Q
E
D
I
S
R
L
R
R
K
L
E
Site 76
Y928
K
Q
R
K
V
E
V
Y
A
D
A
D
E
I
L
Site 77
Y942
L
Q
E
E
I
K
E
Y
K
A
R
L
T
C
P
Site 78
Y976
F
E
C
V
R
G
R
Y
E
A
R
Q
R
K
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation