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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHF2
Full Name:
PHD finger protein 2
Alias:
GRC5; KIAA0662
Type:
Uncharacterized protein
Mass (Da):
120775
Number AA:
1096
UniProt ID:
O75151
International Prot ID:
IPI00260388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y48
E
A
P
D
I
D
I
Y
H
C
P
N
C
E
K
Site 2
T56
H
C
P
N
C
E
K
T
H
G
K
S
T
L
K
Site 3
T67
S
T
L
K
K
K
R
T
W
H
K
H
G
P
G
Site 4
S86
V
K
P
V
Q
N
G
S
Q
L
F
I
K
E
L
Site 5
S95
L
F
I
K
E
L
R
S
R
T
F
P
S
A
E
Site 6
T97
I
K
E
L
R
S
R
T
F
P
S
A
E
D
V
Site 7
T124
Y
M
E
E
H
G
F
T
E
P
I
L
V
P
K
Site 8
Y145
A
V
P
A
P
T
F
Y
V
S
D
V
E
N
Y
Site 9
S147
P
A
P
T
F
Y
V
S
D
V
E
N
Y
V
G
Site 10
Y152
Y
V
S
D
V
E
N
Y
V
G
P
E
R
S
V
Site 11
S158
N
Y
V
G
P
E
R
S
V
D
V
T
D
V
T
Site 12
T162
P
E
R
S
V
D
V
T
D
V
T
K
Q
K
D
Site 13
T165
S
V
D
V
T
D
V
T
K
Q
K
D
C
K
M
Site 14
Y180
K
L
K
E
F
V
D
Y
Y
Y
S
T
N
R
K
Site 15
Y181
L
K
E
F
V
D
Y
Y
Y
S
T
N
R
K
R
Site 16
Y182
K
E
F
V
D
Y
Y
Y
S
T
N
R
K
R
V
Site 17
T184
F
V
D
Y
Y
Y
S
T
N
R
K
R
V
L
N
Site 18
T193
R
K
R
V
L
N
V
T
N
L
E
F
S
D
T
Site 19
S198
N
V
T
N
L
E
F
S
D
T
R
M
S
S
F
Site 20
T200
T
N
L
E
F
S
D
T
R
M
S
S
F
V
E
Site 21
S203
E
F
S
D
T
R
M
S
S
F
V
E
P
P
D
Site 22
S204
F
S
D
T
R
M
S
S
F
V
E
P
P
D
I
Site 23
Y245
L
I
C
V
K
D
S
Y
T
D
F
H
I
D
S
Site 24
Y259
S
G
G
A
S
A
W
Y
H
V
L
K
G
E
K
Site 25
T267
H
V
L
K
G
E
K
T
F
Y
L
I
R
P
A
Site 26
Y269
L
K
G
E
K
T
F
Y
L
I
R
P
A
S
A
Site 27
S279
R
P
A
S
A
N
I
S
L
Y
E
R
W
R
S
Site 28
Y281
A
S
A
N
I
S
L
Y
E
R
W
R
S
A
S
Site 29
S286
S
L
Y
E
R
W
R
S
A
S
N
H
S
E
M
Site 30
Y303
A
D
Q
V
D
K
C
Y
K
C
I
V
K
Q
G
Site 31
S341
G
H
F
L
H
S
L
S
V
E
M
Q
M
R
A
Site 32
Y349
V
E
M
Q
M
R
A
Y
E
V
E
R
R
L
K
Site 33
S359
E
R
R
L
K
L
G
S
L
T
Q
F
P
N
F
Site 34
T361
R
L
K
L
G
S
L
T
Q
F
P
N
F
E
T
Site 35
S387
A
F
K
G
S
H
K
S
G
K
Q
L
P
P
H
Site 36
S408
I
L
N
G
A
F
R
S
W
T
K
K
Q
A
L
Site 37
T410
N
G
A
F
R
S
W
T
K
K
Q
A
L
A
E
Site 38
S442
L
A
K
E
I
R
L
S
E
N
A
S
K
A
V
Site 39
S446
I
R
L
S
E
N
A
S
K
A
V
R
P
E
V
Site 40
T455
A
V
R
P
E
V
N
T
V
A
S
S
D
E
V
Site 41
S458
P
E
V
N
T
V
A
S
S
D
E
V
C
D
G
Site 42
S459
E
V
N
T
V
A
S
S
D
E
V
C
D
G
D
Site 43
S474
R
E
K
E
E
P
P
S
P
I
E
A
T
P
P
Site 44
T479
P
P
S
P
I
E
A
T
P
P
Q
S
L
L
E
Site 45
S483
I
E
A
T
P
P
Q
S
L
L
E
K
V
S
K
Site 46
S489
Q
S
L
L
E
K
V
S
K
K
K
T
P
K
T
Site 47
T493
E
K
V
S
K
K
K
T
P
K
T
V
K
M
P
Site 48
T496
S
K
K
K
T
P
K
T
V
K
M
P
K
P
S
Site 49
S503
T
V
K
M
P
K
P
S
K
I
P
K
P
P
K
Site 50
T520
K
P
P
R
P
P
K
T
L
K
L
K
D
G
G
Site 51
S534
G
K
K
K
G
K
K
S
R
E
S
A
S
P
T
Site 52
S537
K
G
K
K
S
R
E
S
A
S
P
T
I
P
N
Site 53
S539
K
K
S
R
E
S
A
S
P
T
I
P
N
L
D
Site 54
T541
S
R
E
S
A
S
P
T
I
P
N
L
D
L
L
Site 55
S570
K
K
G
K
A
T
K
S
V
L
S
V
P
N
K
Site 56
S573
K
A
T
K
S
V
L
S
V
P
N
K
D
V
V
Site 57
T595
R
L
E
I
R
E
Q
T
K
S
K
S
E
A
K
Site 58
S597
E
I
R
E
Q
T
K
S
K
S
E
A
K
W
K
Site 59
S599
R
E
Q
T
K
S
K
S
E
A
K
W
K
Y
K
Site 60
Y605
K
S
E
A
K
W
K
Y
K
N
S
K
P
D
S
Site 61
S608
A
K
W
K
Y
K
N
S
K
P
D
S
L
L
K
Site 62
S612
Y
K
N
S
K
P
D
S
L
L
K
M
E
E
E
Site 63
S625
E
E
Q
K
L
E
K
S
P
L
A
G
N
K
D
Site 64
S636
G
N
K
D
N
K
F
S
F
S
F
S
N
K
K
Site 65
S638
K
D
N
K
F
S
F
S
F
S
N
K
K
L
L
Site 66
S640
N
K
F
S
F
S
F
S
N
K
K
L
L
G
S
Site 67
T654
S
K
A
L
R
P
P
T
S
P
G
V
F
G
A
Site 68
S655
K
A
L
R
P
P
T
S
P
G
V
F
G
A
L
Site 69
Y677
P
K
P
V
R
D
E
Y
E
Y
V
S
D
D
G
Site 70
Y679
P
V
R
D
E
Y
E
Y
V
S
D
D
G
E
L
Site 71
S681
R
D
E
Y
E
Y
V
S
D
D
G
E
L
K
I
Site 72
S705
N
A
P
K
R
D
L
S
F
L
L
D
K
K
A
Site 73
T716
D
K
K
A
V
L
P
T
P
V
T
K
P
K
L
Site 74
T719
A
V
L
P
T
P
V
T
K
P
K
L
D
S
A
Site 75
Y728
P
K
L
D
S
A
A
Y
K
S
D
D
S
S
D
Site 76
S730
L
D
S
A
A
Y
K
S
D
D
S
S
D
E
G
Site 77
S733
A
A
Y
K
S
D
D
S
S
D
E
G
S
L
H
Site 78
S734
A
Y
K
S
D
D
S
S
D
E
G
S
L
H
I
Site 79
S738
D
D
S
S
D
E
G
S
L
H
I
D
T
D
T
Site 80
T743
E
G
S
L
H
I
D
T
D
T
K
P
G
R
N
Site 81
T745
S
L
H
I
D
T
D
T
K
P
G
R
N
A
R
Site 82
S757
N
A
R
V
K
K
E
S
G
S
S
A
A
G
I
Site 83
S759
R
V
K
K
E
S
G
S
S
A
A
G
I
L
D
Site 84
S760
V
K
K
E
S
G
S
S
A
A
G
I
L
D
L
Site 85
S771
I
L
D
L
L
Q
A
S
E
E
V
G
A
L
E
Site 86
Y779
E
E
V
G
A
L
E
Y
N
P
S
S
Q
P
P
Site 87
S782
G
A
L
E
Y
N
P
S
S
Q
P
P
A
S
P
Site 88
S783
A
L
E
Y
N
P
S
S
Q
P
P
A
S
P
S
Site 89
S788
P
S
S
Q
P
P
A
S
P
S
T
Q
E
A
I
Site 90
S790
S
Q
P
P
A
S
P
S
T
Q
E
A
I
Q
G
Site 91
S807
S
M
A
N
L
Q
A
S
D
S
C
L
Q
T
T
Site 92
S809
A
N
L
Q
A
S
D
S
C
L
Q
T
T
W
G
Site 93
T813
A
S
D
S
C
L
Q
T
T
W
G
A
G
Q
A
Site 94
S824
A
G
Q
A
K
G
S
S
L
A
A
H
G
A
R
Site 95
S840
N
G
G
G
S
G
K
S
A
G
K
R
L
L
K
Site 96
S853
L
K
R
A
A
K
N
S
V
D
L
D
D
Y
E
Site 97
Y859
N
S
V
D
L
D
D
Y
E
E
E
Q
D
H
L
Site 98
S873
L
D
A
C
F
K
D
S
D
Y
V
Y
P
S
L
Site 99
Y875
A
C
F
K
D
S
D
Y
V
Y
P
S
L
E
S
Site 100
Y877
F
K
D
S
D
Y
V
Y
P
S
L
E
S
D
E
Site 101
S879
D
S
D
Y
V
Y
P
S
L
E
S
D
E
D
N
Site 102
S882
Y
V
Y
P
S
L
E
S
D
E
D
N
P
I
F
Site 103
S891
E
D
N
P
I
F
K
S
R
S
K
K
R
K
G
Site 104
S893
N
P
I
F
K
S
R
S
K
K
R
K
G
S
D
Site 105
S899
R
S
K
K
R
K
G
S
D
D
A
P
Y
S
P
Site 106
Y904
K
G
S
D
D
A
P
Y
S
P
T
A
R
V
G
Site 107
S905
G
S
D
D
A
P
Y
S
P
T
A
R
V
G
P
Site 108
T907
D
D
A
P
Y
S
P
T
A
R
V
G
P
S
V
Site 109
S913
P
T
A
R
V
G
P
S
V
P
R
Q
D
R
P
Site 110
T925
D
R
P
V
R
E
G
T
R
V
A
S
I
E
T
Site 111
S929
R
E
G
T
R
V
A
S
I
E
T
G
L
A
A
Site 112
S942
A
A
A
A
A
K
L
S
Q
Q
E
E
Q
K
S
Site 113
S949
S
Q
Q
E
E
Q
K
S
K
K
K
K
S
A
K
Site 114
S954
Q
K
S
K
K
K
K
S
A
K
R
K
L
T
P
Site 115
T960
K
S
A
K
R
K
L
T
P
N
T
T
S
P
S
Site 116
T963
K
R
K
L
T
P
N
T
T
S
P
S
T
S
T
Site 117
T964
R
K
L
T
P
N
T
T
S
P
S
T
S
T
S
Site 118
S965
K
L
T
P
N
T
T
S
P
S
T
S
T
S
I
Site 119
S967
T
P
N
T
T
S
P
S
T
S
T
S
I
S
A
Site 120
T968
P
N
T
T
S
P
S
T
S
T
S
I
S
A
G
Site 121
S969
N
T
T
S
P
S
T
S
T
S
I
S
A
G
T
Site 122
S971
T
S
P
S
T
S
T
S
I
S
A
G
T
T
S
Site 123
S973
P
S
T
S
T
S
I
S
A
G
T
T
S
T
S
Site 124
T976
S
T
S
I
S
A
G
T
T
S
T
S
T
T
P
Site 125
T977
T
S
I
S
A
G
T
T
S
T
S
T
T
P
A
Site 126
S978
S
I
S
A
G
T
T
S
T
S
T
T
P
A
S
Site 127
S980
S
A
G
T
T
S
T
S
T
T
P
A
S
T
T
Site 128
T981
A
G
T
T
S
T
S
T
T
P
A
S
T
T
P
Site 129
T982
G
T
T
S
T
S
T
T
P
A
S
T
T
P
A
Site 130
S985
S
T
S
T
T
P
A
S
T
T
P
A
S
T
T
Site 131
T987
S
T
T
P
A
S
T
T
P
A
S
T
T
P
A
Site 132
S990
P
A
S
T
T
P
A
S
T
T
P
A
S
T
S
Site 133
T991
A
S
T
T
P
A
S
T
T
P
A
S
T
S
T
Site 134
T992
S
T
T
P
A
S
T
T
P
A
S
T
S
T
A
Site 135
S995
P
A
S
T
T
P
A
S
T
S
T
A
S
S
Q
Site 136
S997
S
T
T
P
A
S
T
S
T
A
S
S
Q
A
S
Site 137
S1000
P
A
S
T
S
T
A
S
S
Q
A
S
Q
E
G
Site 138
S1001
A
S
T
S
T
A
S
S
Q
A
S
Q
E
G
S
Site 139
S1004
S
T
A
S
S
Q
A
S
Q
E
G
S
S
P
E
Site 140
S1008
S
Q
A
S
Q
E
G
S
S
P
E
P
P
P
E
Site 141
S1009
Q
A
S
Q
E
G
S
S
P
E
P
P
P
E
S
Site 142
S1016
S
P
E
P
P
P
E
S
H
S
S
S
L
A
D
Site 143
S1018
E
P
P
P
E
S
H
S
S
S
L
A
D
H
E
Site 144
S1019
P
P
P
E
S
H
S
S
S
L
A
D
H
E
Y
Site 145
S1020
P
P
E
S
H
S
S
S
L
A
D
H
E
Y
T
Site 146
Y1026
S
S
L
A
D
H
E
Y
T
A
A
G
T
F
T
Site 147
S1041
G
A
Q
A
G
R
T
S
Q
P
M
A
P
G
V
Site 148
T1051
M
A
P
G
V
F
L
T
Q
R
R
P
S
A
S
Site 149
S1056
F
L
T
Q
R
R
P
S
A
S
S
P
N
N
N
Site 150
S1058
T
Q
R
R
P
S
A
S
S
P
N
N
N
T
A
Site 151
S1059
Q
R
R
P
S
A
S
S
P
N
N
N
T
A
A
Site 152
T1064
A
S
S
P
N
N
N
T
A
A
K
G
K
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation