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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0664
Full Name:
Protein KIAA0664
Alias:
CLU1; EIF-3; EIF3X; Eukaryotic translation initiation factor 3; IF3X
Type:
Mass (Da):
146670
Number AA:
1309
UniProt ID:
O75153
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
N
G
D
C
P
E
S
L
K
K
E
A
A
A
Site 2
T35
E
A
G
P
G
D
E
T
T
G
Q
E
V
I
V
Site 3
S61
A
P
G
I
E
P
F
S
L
Q
V
S
P
Q
E
Site 4
S65
E
P
F
S
L
Q
V
S
P
Q
E
M
V
Q
E
Site 5
S102
G
N
V
L
D
H
F
S
E
L
R
S
V
E
G
Site 6
S106
D
H
F
S
E
L
R
S
V
E
G
L
Q
E
G
Site 7
T124
R
V
V
E
E
P
Y
T
V
R
E
A
R
I
H
Site 8
S141
H
V
R
D
L
L
K
S
L
D
P
S
D
A
F
Site 9
S145
L
L
K
S
L
D
P
S
D
A
F
N
G
V
D
Site 10
S170
T
D
G
D
L
G
D
S
G
K
R
K
K
G
L
Site 11
T185
E
M
D
P
I
D
C
T
P
P
E
Y
I
L
P
Site 12
Y189
I
D
C
T
P
P
E
Y
I
L
P
G
S
R
E
Site 13
S194
P
E
Y
I
L
P
G
S
R
E
R
P
L
C
P
Site 14
S250
T
A
E
D
R
Q
V
S
I
T
A
S
T
R
G
Site 15
T252
E
D
R
Q
V
S
I
T
A
S
T
R
G
F
Y
Site 16
S254
R
Q
V
S
I
T
A
S
T
R
G
F
Y
L
N
Site 17
T255
Q
V
S
I
T
A
S
T
R
G
F
Y
L
N
Q
Site 18
Y259
T
A
S
T
R
G
F
Y
L
N
Q
S
T
A
Y
Site 19
S274
H
F
N
P
K
P
A
S
P
R
F
L
S
H
S
Site 20
S279
P
A
S
P
R
F
L
S
H
S
L
V
E
L
L
Site 21
S281
S
P
R
F
L
S
H
S
L
V
E
L
L
N
Q
Site 22
S290
V
E
L
L
N
Q
I
S
P
T
F
K
K
N
F
Site 23
T315
H
P
F
E
R
I
A
T
P
F
Q
V
Y
S
W
Site 24
Y320
I
A
T
P
F
Q
V
Y
S
W
T
A
P
Q
A
Site 25
S321
A
T
P
F
Q
V
Y
S
W
T
A
P
Q
A
E
Site 26
T323
P
F
Q
V
Y
S
W
T
A
P
Q
A
E
H
A
Site 27
Y340
C
V
R
A
E
D
A
Y
T
S
R
L
G
Y
E
Site 28
T341
V
R
A
E
D
A
Y
T
S
R
L
G
Y
E
E
Site 29
Y346
A
Y
T
S
R
L
G
Y
E
E
H
I
P
G
Q
Site 30
T363
D
W
N
E
E
L
Q
T
T
R
E
L
P
R
K
Site 31
T394
S
D
F
T
A
A
A
T
R
G
A
M
A
V
I
Site 32
S411
N
V
M
A
I
N
P
S
E
E
T
K
M
Q
M
Site 33
Y436
G
F
D
V
R
D
H
Y
K
D
F
G
G
D
V
Site 34
Y459
D
L
N
G
V
R
T
Y
N
A
V
D
V
E
G
Site 35
T483
D
Y
R
G
Y
R
V
T
A
Q
S
I
I
P
G
Site 36
S499
L
E
R
D
Q
E
Q
S
V
I
Y
G
S
I
D
Site 37
Y502
D
Q
E
Q
S
V
I
Y
G
S
I
D
F
G
K
Site 38
T510
G
S
I
D
F
G
K
T
V
V
S
H
P
R
Y
Site 39
S513
D
F
G
K
T
V
V
S
H
P
R
Y
L
E
L
Site 40
Y517
T
V
V
S
H
P
R
Y
L
E
L
L
E
R
T
Site 41
T524
Y
L
E
L
L
E
R
T
S
R
P
L
K
I
L
Site 42
S525
L
E
L
L
E
R
T
S
R
P
L
K
I
L
R
Site 43
Y562
I
G
N
D
G
R
H
Y
I
L
D
L
L
R
T
Site 44
S634
Q
L
M
Q
Q
N
A
S
Q
L
E
T
P
S
S
Site 45
T638
Q
N
A
S
Q
L
E
T
P
S
S
L
E
N
G
Site 46
S641
S
Q
L
E
T
P
S
S
L
E
N
G
G
P
S
Site 47
S648
S
L
E
N
G
G
P
S
S
L
E
S
K
S
E
Site 48
S649
L
E
N
G
G
P
S
S
L
E
S
K
S
E
D
Site 49
S652
G
G
P
S
S
L
E
S
K
S
E
D
P
P
G
Site 50
S654
P
S
S
L
E
S
K
S
E
D
P
P
G
Q
E
Site 51
S664
P
P
G
Q
E
A
G
S
E
E
E
G
S
S
A
Site 52
S669
A
G
S
E
E
E
G
S
S
A
S
G
L
A
K
Site 53
S670
G
S
E
E
E
G
S
S
A
S
G
L
A
K
V
Site 54
T683
K
V
K
E
L
A
E
T
I
A
A
D
D
G
T
Site 55
T690
T
I
A
A
D
D
G
T
D
P
R
S
R
E
V
Site 56
S694
D
D
G
T
D
P
R
S
R
E
V
I
R
N
A
Site 57
S723
R
F
N
P
D
I
F
S
P
G
V
R
F
P
E
Site 58
S731
P
G
V
R
F
P
E
S
C
Q
D
E
V
R
D
Site 59
Y788
Q
R
G
I
N
M
R
Y
L
G
K
V
L
E
L
Site 60
S799
V
L
E
L
V
L
R
S
P
A
R
H
Q
L
D
Site 61
T818
I
G
I
G
E
L
I
T
R
S
A
K
H
I
F
Site 62
Y828
A
K
H
I
F
K
T
Y
L
Q
G
V
E
L
S
Site 63
Y905
I
C
Q
E
A
K
N
Y
F
D
F
D
L
E
C
Site 64
Y946
I
Q
V
L
L
K
E
Y
S
F
D
S
R
H
K
Site 65
S947
Q
V
L
L
K
E
Y
S
F
D
S
R
H
K
P
Site 66
S950
L
K
E
Y
S
F
D
S
R
H
K
P
A
F
T
Site 67
T957
S
R
H
K
P
A
F
T
E
E
D
V
L
N
I
Site 68
Y1031
R
L
L
A
R
L
H
Y
I
M
G
D
Y
A
E
Site 69
Y1036
L
H
Y
I
M
G
D
Y
A
E
A
L
S
N
Q
Site 70
S1050
Q
Q
K
A
V
L
M
S
E
R
V
M
G
T
E
Site 71
T1056
M
S
E
R
V
M
G
T
E
H
P
N
T
I
Q
Site 72
S1083
S
Q
L
S
T
A
L
S
L
L
Y
R
A
R
Y
Site 73
S1123
G
V
M
E
Y
D
L
S
L
R
F
L
E
N
A
Site 74
Y1137
A
L
A
V
S
T
K
Y
H
G
P
K
A
L
K
Site 75
Y1156
H
H
L
V
A
R
V
Y
E
S
K
A
E
F
R
Site 76
Y1173
L
Q
H
E
K
E
G
Y
T
I
Y
K
T
Q
L
Site 77
Y1176
E
K
E
G
Y
T
I
Y
K
T
Q
L
G
E
D
Site 78
T1178
E
G
Y
T
I
Y
K
T
Q
L
G
E
D
H
E
Site 79
T1187
L
G
E
D
H
E
K
T
K
E
S
S
E
Y
L
Site 80
Y1193
K
T
K
E
S
S
E
Y
L
K
C
L
T
Q
Q
Site 81
Y1212
Q
R
T
M
N
E
I
Y
R
N
G
S
S
A
N
Site 82
S1216
N
E
I
Y
R
N
G
S
S
A
N
I
P
P
L
Site 83
T1282
R
A
E
E
P
M
A
T
E
P
A
P
A
G
A
Site 84
S1295
G
A
P
G
D
L
G
S
Q
P
P
A
A
K
D
Site 85
S1304
P
P
A
A
K
D
P
S
P
S
V
Q
G
_
_
Site 86
S1306
A
A
K
D
P
S
P
S
V
Q
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation