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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAND2
Full Name:
Cullin-associated NEDD8-dissociated protein 2
Alias:
Cullin-associated and neddylation-dissociated 2; Cullin-associated and neddylation-dissociated protein 2; KIAA0667; P120 CAND2; TBP interacting protein; TBP-interacting protein; TIP120B; Tp120b
Type:
Ubiquitin conjugating system
Mass (Da):
135256
Number AA:
1236
UniProt ID:
O75155
International Prot ID:
IPI00374208
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
S
S
L
L
E
K
M
T
S
S
D
K
D
F
R
Site 2
S17
S
L
L
E
K
M
T
S
S
D
K
D
F
R
F
Site 3
S18
L
L
E
K
M
T
S
S
D
K
D
F
R
F
M
Site 4
S28
D
F
R
F
M
A
T
S
D
L
M
S
E
L
Q
Site 5
S32
M
A
T
S
D
L
M
S
E
L
Q
K
D
S
I
Site 6
S45
S
I
Q
L
D
E
D
S
E
R
K
V
V
K
M
Site 7
T90
Q
V
E
T
I
V
D
T
L
C
T
N
M
R
S
Site 8
T93
T
I
V
D
T
L
C
T
N
M
R
S
D
K
E
Site 9
S97
T
L
C
T
N
M
R
S
D
K
E
Q
L
R
D
Site 10
T229
L
P
G
P
R
V
P
T
S
P
T
A
I
R
T
Site 11
S230
P
G
P
R
V
P
T
S
P
T
A
I
R
T
L
Site 12
S277
D
D
D
E
L
R
E
S
C
L
Q
A
F
E
A
Site 13
Y307
V
T
S
L
C
L
Q
Y
I
K
H
D
P
N
Y
Site 14
Y314
Y
I
K
H
D
P
N
Y
N
Y
D
S
D
E
D
Site 15
Y316
K
H
D
P
N
Y
N
Y
D
S
D
E
D
E
E
Site 16
S318
D
P
N
Y
N
Y
D
S
D
E
D
E
E
Q
M
Site 17
T327
E
D
E
E
Q
M
E
T
E
D
S
E
F
S
E
Site 18
S330
E
Q
M
E
T
E
D
S
E
F
S
E
Q
E
S
Site 19
S333
E
T
E
D
S
E
F
S
E
Q
E
S
E
D
E
Site 20
S337
S
E
F
S
E
Q
E
S
E
D
E
Y
S
D
D
Site 21
Y341
E
Q
E
S
E
D
E
Y
S
D
D
D
D
M
S
Site 22
S342
Q
E
S
E
D
E
Y
S
D
D
D
D
M
S
W
Site 23
S348
Y
S
D
D
D
D
M
S
W
K
V
R
R
A
A
Site 24
S365
C
I
A
A
L
I
S
S
R
P
D
L
L
P
D
Site 25
T407
Y
I
V
L
L
R
Q
T
Q
P
P
K
G
W
L
Site 26
T423
A
M
E
E
P
T
Q
T
G
S
N
L
H
M
L
Site 27
S425
E
E
P
T
Q
T
G
S
N
L
H
M
L
R
G
Site 28
S449
Q
R
Q
L
K
D
R
S
V
R
A
R
Q
G
C
Site 29
S490
I
F
S
L
A
D
R
S
S
S
S
T
I
R
M
Site 30
S491
F
S
L
A
D
R
S
S
S
S
T
I
R
M
D
Site 31
S492
S
L
A
D
R
S
S
S
S
T
I
R
M
D
A
Site 32
T494
A
D
R
S
S
S
S
T
I
R
M
D
A
L
A
Site 33
Y566
R
M
L
D
P
E
P
Y
V
G
E
M
S
A
V
Site 34
T581
T
L
A
R
L
R
A
T
D
L
D
Q
E
V
K
Site 35
T635
L
P
A
I
K
A
L
T
L
V
A
V
S
P
L
Site 36
S640
A
L
T
L
V
A
V
S
P
L
Q
L
D
L
Q
Site 37
S659
E
A
L
H
I
L
A
S
F
L
R
K
N
Q
R
Site 38
S686
L
A
Q
S
Q
G
L
S
L
P
P
S
A
V
Q
Site 39
T822
C
P
Q
E
A
A
S
T
A
S
R
L
V
C
D
Site 40
S832
R
L
V
C
D
A
R
S
P
H
S
S
T
G
V
Site 41
S836
D
A
R
S
P
H
S
S
T
G
V
K
V
L
A
Site 42
T837
A
R
S
P
H
S
S
T
G
V
K
V
L
A
F
Site 43
S882
E
D
V
R
A
A
A
S
Y
A
L
G
R
V
G
Site 44
Y912
E
A
E
P
R
R
Q
Y
L
L
L
H
S
L
R
Site 45
S917
R
Q
Y
L
L
L
H
S
L
R
E
A
L
G
A
Site 46
S929
L
G
A
A
Q
P
D
S
L
K
P
Y
A
E
D
Site 47
Y933
Q
P
D
S
L
K
P
Y
A
E
D
I
W
A
L
Site 48
T986
L
A
A
G
R
P
H
T
R
S
T
V
I
T
A
Site 49
S988
A
G
R
P
H
T
R
S
T
V
I
T
A
V
K
Site 50
T989
G
R
P
H
T
R
S
T
V
I
T
A
V
K
F
Site 51
S999
T
A
V
K
F
L
I
S
D
Q
P
H
P
I
D
Site 52
S1019
F
I
G
E
F
M
E
S
L
Q
D
P
D
L
N
Site 53
S1037
A
T
L
A
F
F
N
S
A
V
H
N
K
P
S
Site 54
S1044
S
A
V
H
N
K
P
S
L
V
R
D
L
L
D
Site 55
Y1058
D
D
I
L
P
L
L
Y
Q
E
T
K
I
R
R
Site 56
T1079
E
M
G
P
F
K
H
T
V
D
D
G
L
D
V
Site 57
Y1122
E
D
G
L
K
D
H
Y
D
I
R
M
L
T
F
Site 58
T1159
E
P
L
R
A
T
C
T
A
K
V
K
A
G
S
Site 59
S1180
K
Q
D
E
L
K
R
S
A
M
R
A
V
A
A
Site 60
S1204
S
P
I
M
A
D
F
S
S
Q
I
R
S
N
P
Site 61
S1205
P
I
M
A
D
F
S
S
Q
I
R
S
N
P
E
Site 62
S1209
D
F
S
S
Q
I
R
S
N
P
E
L
A
A
L
Site 63
S1219
E
L
A
A
L
F
E
S
I
Q
K
D
S
A
S
Site 64
S1224
F
E
S
I
Q
K
D
S
A
S
A
P
S
T
D
Site 65
S1226
S
I
Q
K
D
S
A
S
A
P
S
T
D
S
M
Site 66
S1229
K
D
S
A
S
A
P
S
T
D
S
M
E
L
S
Site 67
T1230
D
S
A
S
A
P
S
T
D
S
M
E
L
S
_
Site 68
S1232
A
S
A
P
S
T
D
S
M
E
L
S
_
_
_
Site 69
S1236
S
T
D
S
M
E
L
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation