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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOCS5
Full Name:
Suppressor of cytokine signaling 5
Alias:
CIS6; CIS-6; CIS6, CISH5, CISH6, KIAA0671, cytokine inducible SH2-containing protein 5; CISH5; Cish5; CISH6; Cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5; KIAA0671; SOC5; SOCS-5
Type:
Inhibitor protein
Mass (Da):
61246
Number AA:
536
UniProt ID:
O75159
International Prot ID:
IPI00022271
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0016049
GO:0019221
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
H
E
G
G
S
R
S
E
N
V
D
M
N
S
Site 2
S34
S
E
N
V
D
M
N
S
N
R
C
L
S
V
K
Site 3
S39
M
N
S
N
R
C
L
S
V
K
E
K
N
I
S
Site 4
S46
S
V
K
E
K
N
I
S
I
G
D
S
T
P
Q
Site 5
S50
K
N
I
S
I
G
D
S
T
P
Q
Q
Q
S
S
Site 6
T51
N
I
S
I
G
D
S
T
P
Q
Q
Q
S
S
P
Site 7
S57
S
T
P
Q
Q
Q
S
S
P
L
R
E
N
I
A
Site 8
S70
I
A
L
Q
L
G
L
S
P
S
K
N
S
S
R
Site 9
S72
L
Q
L
G
L
S
P
S
K
N
S
S
R
R
N
Site 10
S75
G
L
S
P
S
K
N
S
S
R
R
N
Q
N
C
Site 11
S76
L
S
P
S
K
N
S
S
R
R
N
Q
N
C
A
Site 12
T84
R
R
N
Q
N
C
A
T
E
I
P
Q
I
V
E
Site 13
S100
S
I
E
K
D
N
D
S
C
V
T
P
G
T
R
Site 14
T103
K
D
N
D
S
C
V
T
P
G
T
R
L
A
R
Site 15
S113
T
R
L
A
R
R
D
S
Y
S
R
H
A
P
W
Site 16
Y114
R
L
A
R
R
D
S
Y
S
R
H
A
P
W
G
Site 17
S115
L
A
R
R
D
S
Y
S
R
H
A
P
W
G
G
Site 18
S127
W
G
G
K
K
K
H
S
C
S
T
K
T
Q
S
Site 19
S129
G
K
K
K
H
S
C
S
T
K
T
Q
S
S
L
Site 20
T130
K
K
K
H
S
C
S
T
K
T
Q
S
S
L
D
Site 21
T132
K
H
S
C
S
T
K
T
Q
S
S
L
D
A
D
Site 22
S134
S
C
S
T
K
T
Q
S
S
L
D
A
D
K
K
Site 23
S147
K
K
F
G
R
T
R
S
G
L
Q
R
R
E
R
Site 24
Y156
L
Q
R
R
E
R
R
Y
G
V
S
S
V
H
D
Site 25
S159
R
E
R
R
Y
G
V
S
S
V
H
D
M
D
S
Site 26
S160
E
R
R
Y
G
V
S
S
V
H
D
M
D
S
V
Site 27
S166
S
S
V
H
D
M
D
S
V
S
S
R
T
V
G
Site 28
S168
V
H
D
M
D
S
V
S
S
R
T
V
G
S
R
Site 29
T171
M
D
S
V
S
S
R
T
V
G
S
R
S
L
R
Site 30
S174
V
S
S
R
T
V
G
S
R
S
L
R
Q
R
L
Site 31
S176
S
R
T
V
G
S
R
S
L
R
Q
R
L
Q
D
Site 32
T193
G
L
C
F
P
M
R
T
Y
S
K
Q
S
K
P
Site 33
Y194
L
C
F
P
M
R
T
Y
S
K
Q
S
K
P
L
Site 34
S195
C
F
P
M
R
T
Y
S
K
Q
S
K
P
L
F
Site 35
S203
K
Q
S
K
P
L
F
S
N
K
R
K
I
H
L
Site 36
S211
N
K
R
K
I
H
L
S
E
L
M
L
E
K
C
Site 37
S224
K
C
P
F
P
A
G
S
D
L
A
Q
K
W
H
Site 38
T237
W
H
L
I
K
Q
H
T
A
P
V
S
P
H
S
Site 39
S241
K
Q
H
T
A
P
V
S
P
H
S
T
F
F
D
Site 40
S244
T
A
P
V
S
P
H
S
T
F
F
D
T
F
D
Site 41
T245
A
P
V
S
P
H
S
T
F
F
D
T
F
D
P
Site 42
T249
P
H
S
T
F
F
D
T
F
D
P
S
L
V
S
Site 43
S253
F
F
D
T
F
D
P
S
L
V
S
T
E
D
E
Site 44
T257
F
D
P
S
L
V
S
T
E
D
E
E
D
R
L
Site 45
S271
L
R
E
R
R
R
L
S
I
E
E
G
V
D
P
Site 46
T286
P
P
N
A
Q
I
H
T
F
E
A
T
A
Q
V
Site 47
Y297
T
A
Q
V
N
P
L
Y
K
L
G
P
K
L
A
Site 48
T308
P
K
L
A
P
G
M
T
E
I
S
G
D
S
S
Site 49
S311
A
P
G
M
T
E
I
S
G
D
S
S
A
I
P
Site 50
S315
T
E
I
S
G
D
S
S
A
I
P
Q
A
N
C
Site 51
S324
I
P
Q
A
N
C
D
S
E
E
D
T
T
T
L
Site 52
T328
N
C
D
S
E
E
D
T
T
T
L
C
L
Q
S
Site 53
T329
C
D
S
E
E
D
T
T
T
L
C
L
Q
S
R
Site 54
T330
D
S
E
E
D
T
T
T
L
C
L
Q
S
R
R
Site 55
S335
T
T
T
L
C
L
Q
S
R
R
Q
K
Q
R
Q
Site 56
S344
R
Q
K
Q
R
Q
I
S
G
D
S
H
T
H
V
Site 57
S347
Q
R
Q
I
S
G
D
S
H
T
H
V
S
R
Q
Site 58
T349
Q
I
S
G
D
S
H
T
H
V
S
R
Q
G
A
Site 59
Y365
K
V
H
T
Q
I
D
Y
I
H
C
L
V
P
D
Site 60
Y389
Y
W
G
V
M
D
R
Y
E
A
E
A
L
L
E
Site 61
T402
L
E
G
K
P
E
G
T
F
L
L
R
D
S
A
Site 62
S408
G
T
F
L
L
R
D
S
A
Q
E
D
Y
L
F
Site 63
Y413
R
D
S
A
Q
E
D
Y
L
F
S
V
S
F
R
Site 64
S416
A
Q
E
D
Y
L
F
S
V
S
F
R
R
Y
N
Site 65
S418
E
D
Y
L
F
S
V
S
F
R
R
Y
N
R
S
Site 66
Y422
F
S
V
S
F
R
R
Y
N
R
S
L
H
A
R
Site 67
S425
S
F
R
R
Y
N
R
S
L
H
A
R
I
E
Q
Site 68
S438
E
Q
W
N
H
N
F
S
F
D
A
H
D
P
C
Site 69
T453
V
F
H
S
S
T
V
T
G
L
L
E
H
Y
K
Site 70
Y459
V
T
G
L
L
E
H
Y
K
D
P
S
S
C
M
Site 71
Y517
L
Q
D
F
L
K
E
Y
H
Y
K
Q
K
V
R
Site 72
Y519
D
F
L
K
E
Y
H
Y
K
Q
K
V
R
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation