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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHACTR2
Full Name:
Phosphatase and actin regulator 2
Alias:
C6orf56; KIAA0680; PHAR2
Type:
Phosphatase, actin binding protein
Mass (Da):
69700
Number AA:
634
UniProt ID:
O75167
International Prot ID:
IPI00401142
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004864
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
D
G
L
D
K
A
S
I
A
N
S
D
G
P
Site 2
S16
D
K
A
S
I
A
N
S
D
G
P
T
A
G
S
Site 3
T20
I
A
N
S
D
G
P
T
A
G
S
Q
T
P
P
Site 4
S23
S
D
G
P
T
A
G
S
Q
T
P
P
F
K
R
Site 5
T25
G
P
T
A
G
S
Q
T
P
P
F
K
R
K
G
Site 6
S35
F
K
R
K
G
K
L
S
T
I
G
K
I
F
K
Site 7
S52
K
W
R
K
K
K
T
S
D
K
F
R
E
T
S
Site 8
T58
T
S
D
K
F
R
E
T
S
A
V
L
E
R
K
Site 9
S59
S
D
K
F
R
E
T
S
A
V
L
E
R
K
I
Site 10
S67
A
V
L
E
R
K
I
S
T
R
Q
S
R
E
E
Site 11
S71
R
K
I
S
T
R
Q
S
R
E
E
L
I
R
R
Site 12
T92
P
D
Q
D
G
D
V
T
V
N
F
E
N
S
N
Site 13
S109
M
I
P
I
G
E
E
S
T
R
E
E
N
V
V
Site 14
S118
R
E
E
N
V
V
K
S
E
E
G
N
G
S
V
Site 15
S124
K
S
E
E
G
N
G
S
V
S
E
K
T
P
P
Site 16
S126
E
E
G
N
G
S
V
S
E
K
T
P
P
L
E
Site 17
T129
N
G
S
V
S
E
K
T
P
P
L
E
E
Q
A
Site 18
T149
N
T
E
N
H
S
E
T
P
A
A
P
A
L
P
Site 19
S158
A
A
P
A
L
P
P
S
A
P
P
K
P
R
P
Site 20
S172
P
K
P
K
P
K
K
S
P
V
P
P
K
G
A
Site 21
S213
V
P
P
P
K
P
A
S
R
N
T
T
R
E
A
Site 22
T216
P
K
P
A
S
R
N
T
T
R
E
A
A
G
S
Site 23
T217
K
P
A
S
R
N
T
T
R
E
A
A
G
S
S
Site 24
S223
T
T
R
E
A
A
G
S
S
H
S
K
K
T
T
Site 25
S224
T
R
E
A
A
G
S
S
H
S
K
K
T
T
G
Site 26
T230
S
S
H
S
K
K
T
T
G
S
K
A
S
A
S
Site 27
S232
H
S
K
K
T
T
G
S
K
A
S
A
S
P
S
Site 28
S235
K
T
T
G
S
K
A
S
A
S
P
S
T
S
S
Site 29
S237
T
G
S
K
A
S
A
S
P
S
T
S
S
T
S
Site 30
S239
S
K
A
S
A
S
P
S
T
S
S
T
S
S
R
Site 31
T240
K
A
S
A
S
P
S
T
S
S
T
S
S
R
P
Site 32
S241
A
S
A
S
P
S
T
S
S
T
S
S
R
P
K
Site 33
S242
S
A
S
P
S
T
S
S
T
S
S
R
P
K
A
Site 34
T243
A
S
P
S
T
S
S
T
S
S
R
P
K
A
S
Site 35
S244
S
P
S
T
S
S
T
S
S
R
P
K
A
S
K
Site 36
S245
P
S
T
S
S
T
S
S
R
P
K
A
S
K
E
Site 37
S250
T
S
S
R
P
K
A
S
K
E
T
V
S
S
K
Site 38
T253
R
P
K
A
S
K
E
T
V
S
S
K
A
G
T
Site 39
S256
A
S
K
E
T
V
S
S
K
A
G
T
V
G
T
Site 40
T260
T
V
S
S
K
A
G
T
V
G
T
T
K
G
K
Site 41
T270
T
T
K
G
K
R
K
T
D
K
Q
P
I
T
S
Site 42
T276
K
T
D
K
Q
P
I
T
S
H
L
S
S
D
T
Site 43
S277
T
D
K
Q
P
I
T
S
H
L
S
S
D
T
T
Site 44
S280
Q
P
I
T
S
H
L
S
S
D
T
T
T
S
G
Site 45
S281
P
I
T
S
H
L
S
S
D
T
T
T
S
G
T
Site 46
T283
T
S
H
L
S
S
D
T
T
T
S
G
T
S
D
Site 47
T284
S
H
L
S
S
D
T
T
T
S
G
T
S
D
L
Site 48
T285
H
L
S
S
D
T
T
T
S
G
T
S
D
L
K
Site 49
S286
L
S
S
D
T
T
T
S
G
T
S
D
L
K
G
Site 50
T298
L
K
G
E
P
A
E
T
R
V
E
S
F
K
L
Site 51
S302
P
A
E
T
R
V
E
S
F
K
L
E
Q
T
V
Site 52
T308
E
S
F
K
L
E
Q
T
V
P
G
A
E
E
Q
Site 53
T317
P
G
A
E
E
Q
N
T
G
K
F
K
S
M
V
Site 54
S322
Q
N
T
G
K
F
K
S
M
V
P
P
P
P
V
Site 55
S371
P
V
S
A
L
D
P
S
Q
L
L
W
A
E
E
Site 56
T380
L
L
W
A
E
E
P
T
N
R
T
T
L
Y
S
Site 57
T384
E
E
P
T
N
R
T
T
L
Y
S
G
T
G
L
Site 58
Y386
P
T
N
R
T
T
L
Y
S
G
T
G
L
S
V
Site 59
S387
T
N
R
T
T
L
Y
S
G
T
G
L
S
V
N
Site 60
S392
L
Y
S
G
T
G
L
S
V
N
R
E
N
A
K
Site 61
T410
T
K
E
E
L
G
K
T
V
P
Q
L
L
T
P
Site 62
T416
K
T
V
P
Q
L
L
T
P
G
L
M
G
E
S
Site 63
S423
T
P
G
L
M
G
E
S
S
E
S
F
S
A
S
Site 64
S424
P
G
L
M
G
E
S
S
E
S
F
S
A
S
E
Site 65
S426
L
M
G
E
S
S
E
S
F
S
A
S
E
D
E
Site 66
S428
G
E
S
S
E
S
F
S
A
S
E
D
E
G
H
Site 67
S430
S
S
E
S
F
S
A
S
E
D
E
G
H
R
E
Site 68
Y438
E
D
E
G
H
R
E
Y
Q
A
N
D
S
D
S
Site 69
S443
R
E
Y
Q
A
N
D
S
D
S
D
G
P
I
L
Site 70
S445
Y
Q
A
N
D
S
D
S
D
G
P
I
L
Y
T
Site 71
Y451
D
S
D
G
P
I
L
Y
T
D
D
E
D
E
D
Site 72
T452
S
D
G
P
I
L
Y
T
D
D
E
D
E
D
E
Site 73
S464
E
D
E
D
E
D
G
S
G
E
S
A
L
A
S
Site 74
S471
S
G
E
S
A
L
A
S
K
I
R
R
R
D
T
Site 75
T478
S
K
I
R
R
R
D
T
L
A
I
K
L
G
N
Site 76
S488
I
K
L
G
N
R
P
S
K
K
E
L
E
D
K
Site 77
S502
K
N
I
L
Q
R
T
S
E
E
E
R
Q
E
I
Site 78
T515
E
I
R
Q
Q
I
G
T
K
L
V
R
R
L
S
Site 79
S522
T
K
L
V
R
R
L
S
Q
R
P
T
T
E
E
Site 80
T526
R
R
L
S
Q
R
P
T
T
E
E
L
E
Q
R
Site 81
T527
R
L
S
Q
R
P
T
T
E
E
L
E
Q
R
N
Site 82
S556
M
E
L
K
R
R
L
S
R
K
L
S
L
R
P
Site 83
S560
R
R
L
S
R
K
L
S
L
R
P
T
V
A
E
Site 84
T564
R
K
L
S
L
R
P
T
V
A
E
L
Q
A
R
Site 85
Y579
R
I
L
R
F
N
E
Y
V
E
V
T
D
S
P
Site 86
S585
E
Y
V
E
V
T
D
S
P
D
Y
D
R
R
A
Site 87
Y588
E
V
T
D
S
P
D
Y
D
R
R
A
D
K
P
Site 88
T600
D
K
P
W
A
R
L
T
P
A
D
K
A
A
I
Site 89
S616
K
E
L
N
E
F
K
S
T
E
M
E
V
H
E
Site 90
T617
E
L
N
E
F
K
S
T
E
M
E
V
H
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation