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Updated November 2019
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Protein Info
Short Name:
PPFIA2
Full Name:
Liprin-alpha-2
Alias:
LIPA2; Liprin-alpha2; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2; Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) interacting protein (liprin) alpha 2; PTPRF interacting protein alpha 2
Type:
Protein phosphatase regulatory protein, mediator of protein interaction
Mass (Da):
143142
Number AA:
1257
UniProt ID:
O75334
International Prot ID:
IPI00289271
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
M
P
T
I
N
E
D
T
P
M
S
Q
R
G
S
Site 2
S16
I
N
E
D
T
P
M
S
Q
R
G
S
Q
S
S
Site 3
S20
T
P
M
S
Q
R
G
S
Q
S
S
G
S
D
S
Site 4
S22
M
S
Q
R
G
S
Q
S
S
G
S
D
S
D
S
Site 5
S23
S
Q
R
G
S
Q
S
S
G
S
D
S
D
S
H
Site 6
S25
R
G
S
Q
S
S
G
S
D
S
D
S
H
F
E
Site 7
S27
S
Q
S
S
G
S
D
S
D
S
H
F
E
Q
L
Site 8
S29
S
S
G
S
D
S
D
S
H
F
E
Q
L
M
V
Site 9
T48
E
R
D
R
L
L
D
T
L
R
E
T
Q
E
S
Site 10
T52
L
L
D
T
L
R
E
T
Q
E
S
L
S
L
A
Site 11
S55
T
L
R
E
T
Q
E
S
L
S
L
A
Q
Q
R
Site 12
S57
R
E
T
Q
E
S
L
S
L
A
Q
Q
R
L
Q
Site 13
Y68
Q
R
L
Q
D
V
I
Y
D
R
D
S
L
Q
R
Site 14
S72
D
V
I
Y
D
R
D
S
L
Q
R
Q
L
N
S
Site 15
S125
L
E
K
E
E
E
I
S
E
L
K
A
E
R
N
Site 16
T134
L
K
A
E
R
N
N
T
R
L
L
L
E
H
L
Site 17
S146
E
H
L
E
C
L
V
S
R
H
E
R
S
L
R
Site 18
S151
L
V
S
R
H
E
R
S
L
R
M
T
V
V
K
Site 19
T155
H
E
R
S
L
R
M
T
V
V
K
R
Q
A
Q
Site 20
S163
V
V
K
R
Q
A
Q
S
P
S
G
V
S
S
E
Site 21
S165
K
R
Q
A
Q
S
P
S
G
V
S
S
E
V
E
Site 22
S168
A
Q
S
P
S
G
V
S
S
E
V
E
V
L
K
Site 23
S169
Q
S
P
S
G
V
S
S
E
V
E
V
L
K
A
Site 24
S179
E
V
L
K
A
L
K
S
L
F
E
H
H
K
A
Site 25
S198
V
R
E
R
L
R
V
S
L
E
R
V
S
A
L
Site 26
S203
R
V
S
L
E
R
V
S
A
L
E
E
E
L
A
Site 27
S232
H
I
Q
R
K
M
A
S
S
E
G
S
T
E
S
Site 28
S233
I
Q
R
K
M
A
S
S
E
G
S
T
E
S
E
Site 29
S236
K
M
A
S
S
E
G
S
T
E
S
E
H
L
E
Site 30
T237
M
A
S
S
E
G
S
T
E
S
E
H
L
E
G
Site 31
S239
S
S
E
G
S
T
E
S
E
H
L
E
G
M
E
Site 32
S257
K
V
H
E
K
R
L
S
N
G
S
I
D
S
T
Site 33
S260
E
K
R
L
S
N
G
S
I
D
S
T
D
E
T
Site 34
S263
L
S
N
G
S
I
D
S
T
D
E
T
S
Q
I
Site 35
T264
S
N
G
S
I
D
S
T
D
E
T
S
Q
I
V
Site 36
T267
S
I
D
S
T
D
E
T
S
Q
I
V
E
L
Q
Site 37
S268
I
D
S
T
D
E
T
S
Q
I
V
E
L
Q
E
Site 38
Y282
E
L
L
E
K
Q
N
Y
E
M
A
Q
M
K
E
Site 39
S295
K
E
R
L
A
A
L
S
S
R
V
G
E
V
E
Site 40
S296
E
R
L
A
A
L
S
S
R
V
G
E
V
E
Q
Site 41
T315
A
R
K
D
L
I
K
T
E
E
M
N
T
K
Y
Site 42
T320
I
K
T
E
E
M
N
T
K
Y
Q
R
D
I
R
Site 43
Y322
T
E
E
M
N
T
K
Y
Q
R
D
I
R
E
A
Site 44
T341
E
D
M
E
E
R
I
T
T
L
E
K
R
Y
L
Site 45
T342
D
M
E
E
R
I
T
T
L
E
K
R
Y
L
S
Site 46
S349
T
L
E
K
R
Y
L
S
A
Q
R
E
S
T
S
Site 47
S354
Y
L
S
A
Q
R
E
S
T
S
I
H
D
M
N
Site 48
T355
L
S
A
Q
R
E
S
T
S
I
H
D
M
N
D
Site 49
T421
A
Q
R
I
A
A
L
T
K
A
E
E
T
H
G
Site 50
S466
E
E
H
N
K
R
L
S
D
T
V
D
R
L
L
Site 51
T468
H
N
K
R
L
S
D
T
V
D
R
L
L
T
E
Site 52
T474
D
T
V
D
R
L
L
T
E
S
N
E
R
L
Q
Site 53
S476
V
D
R
L
L
T
E
S
N
E
R
L
Q
L
H
Site 54
T503
V
L
I
Q
E
S
E
T
F
R
K
N
L
E
E
Site 55
S511
F
R
K
N
L
E
E
S
L
H
D
K
E
S
L
Site 56
S517
E
S
L
H
D
K
E
S
L
A
E
E
I
E
K
Site 57
S527
E
E
I
E
K
L
R
S
E
L
D
Q
L
K
M
Site 58
S538
Q
L
K
M
R
T
G
S
L
I
E
P
T
I
P
Site 59
T543
T
G
S
L
I
E
P
T
I
P
R
T
H
L
D
Site 60
T547
I
E
P
T
I
P
R
T
H
L
D
T
S
A
E
Site 61
T551
I
P
R
T
H
L
D
T
S
A
E
L
R
Y
S
Site 62
S552
P
R
T
H
L
D
T
S
A
E
L
R
Y
S
V
Site 63
Y557
D
T
S
A
E
L
R
Y
S
V
G
S
L
V
D
Site 64
S558
T
S
A
E
L
R
Y
S
V
G
S
L
V
D
S
Site 65
S561
E
L
R
Y
S
V
G
S
L
V
D
S
Q
S
D
Site 66
S565
S
V
G
S
L
V
D
S
Q
S
D
Y
R
T
T
Site 67
S567
G
S
L
V
D
S
Q
S
D
Y
R
T
T
K
V
Site 68
Y569
L
V
D
S
Q
S
D
Y
R
T
T
K
V
I
R
Site 69
T571
D
S
Q
S
D
Y
R
T
T
K
V
I
R
R
P
Site 70
T572
S
Q
S
D
Y
R
T
T
K
V
I
R
R
P
R
Site 71
S594
R
D
E
P
K
V
K
S
L
G
D
H
E
W
N
Site 72
T603
G
D
H
E
W
N
R
T
Q
Q
I
G
V
L
S
Site 73
S610
T
Q
Q
I
G
V
L
S
S
H
P
F
E
S
D
Site 74
S611
Q
Q
I
G
V
L
S
S
H
P
F
E
S
D
T
Site 75
S616
L
S
S
H
P
F
E
S
D
T
E
M
S
D
I
Site 76
T618
S
H
P
F
E
S
D
T
E
M
S
D
I
D
D
Site 77
T630
I
D
D
D
D
R
E
T
I
F
S
S
M
D
L
Site 78
S633
D
D
R
E
T
I
F
S
S
M
D
L
L
S
P
Site 79
S639
F
S
S
M
D
L
L
S
P
S
G
H
S
D
A
Site 80
S641
S
M
D
L
L
S
P
S
G
H
S
D
A
Q
T
Site 81
T648
S
G
H
S
D
A
Q
T
L
A
M
M
L
Q
E
Site 82
S673
L
I
Q
E
E
K
E
S
T
E
L
R
A
E
E
Site 83
T674
I
Q
E
E
K
E
S
T
E
L
R
A
E
E
I
Site 84
S687
E
I
E
N
R
V
A
S
V
S
L
E
G
L
N
Site 85
S689
E
N
R
V
A
S
V
S
L
E
G
L
N
L
A
Site 86
S707
P
G
T
S
I
T
A
S
V
T
A
S
S
L
A
Site 87
S712
T
A
S
V
T
A
S
S
L
A
S
S
S
P
P
Site 88
S715
V
T
A
S
S
L
A
S
S
S
P
P
S
G
H
Site 89
S716
T
A
S
S
L
A
S
S
S
P
P
S
G
H
S
Site 90
S717
A
S
S
L
A
S
S
S
P
P
S
G
H
S
T
Site 91
S720
L
A
S
S
S
P
P
S
G
H
S
T
P
K
L
Site 92
S723
S
S
P
P
S
G
H
S
T
P
K
L
T
P
R
Site 93
T724
S
P
P
S
G
H
S
T
P
K
L
T
P
R
S
Site 94
T728
G
H
S
T
P
K
L
T
P
R
S
P
A
R
E
Site 95
S731
T
P
K
L
T
P
R
S
P
A
R
E
M
D
R
Site 96
T743
M
D
R
M
G
V
M
T
L
P
S
D
L
R
K
Site 97
S746
M
G
V
M
T
L
P
S
D
L
R
K
H
R
R
Site 98
T768
D
G
R
E
D
K
A
T
I
K
C
E
T
S
P
Site 99
T773
K
A
T
I
K
C
E
T
S
P
P
P
T
P
R
Site 100
S774
A
T
I
K
C
E
T
S
P
P
P
T
P
R
A
Site 101
T778
C
E
T
S
P
P
P
T
P
R
A
L
R
M
T
Site 102
T785
T
P
R
A
L
R
M
T
H
T
L
P
S
S
Y
Site 103
T787
R
A
L
R
M
T
H
T
L
P
S
S
Y
H
N
Site 104
S791
M
T
H
T
L
P
S
S
Y
H
N
D
A
R
S
Site 105
Y792
T
H
T
L
P
S
S
Y
H
N
D
A
R
S
S
Site 106
S798
S
Y
H
N
D
A
R
S
S
L
S
V
S
L
E
Site 107
S799
Y
H
N
D
A
R
S
S
L
S
V
S
L
E
P
Site 108
S801
N
D
A
R
S
S
L
S
V
S
L
E
P
E
S
Site 109
S803
A
R
S
S
L
S
V
S
L
E
P
E
S
L
G
Site 110
S808
S
V
S
L
E
P
E
S
L
G
L
G
S
A
N
Site 111
S813
P
E
S
L
G
L
G
S
A
N
S
S
Q
D
S
Site 112
S816
L
G
L
G
S
A
N
S
S
Q
D
S
L
H
K
Site 113
S817
G
L
G
S
A
N
S
S
Q
D
S
L
H
K
A
Site 114
S820
S
A
N
S
S
Q
D
S
L
H
K
A
P
K
K
Site 115
S832
P
K
K
K
G
I
K
S
S
I
G
R
L
F
G
Site 116
S833
K
K
K
G
I
K
S
S
I
G
R
L
F
G
K
Site 117
T855
Q
L
R
G
F
M
E
T
E
A
A
A
Q
E
S
Site 118
T870
L
G
L
G
K
L
G
T
Q
A
E
K
D
R
R
Site 119
S935
G
A
I
M
S
A
L
S
D
T
E
I
Q
R
E
Site 120
S946
I
Q
R
E
I
G
I
S
N
P
L
H
R
L
K
Site 121
S966
Q
E
M
V
S
L
T
S
P
S
A
P
P
T
S
Site 122
S968
M
V
S
L
T
S
P
S
A
P
P
T
S
R
T
Site 123
T972
T
S
P
S
A
P
P
T
S
R
T
P
S
G
N
Site 124
S973
S
P
S
A
P
P
T
S
R
T
P
S
G
N
V
Site 125
T975
S
A
P
P
T
S
R
T
P
S
G
N
V
W
V
Site 126
S977
P
P
T
S
R
T
P
S
G
N
V
W
V
T
H
Site 127
S999
A
P
A
K
T
K
E
S
E
E
G
S
W
A
Q
Site 128
S1003
T
K
E
S
E
E
G
S
W
A
Q
C
P
V
F
Site 129
Y1016
V
F
L
Q
T
L
A
Y
G
D
M
N
H
E
W
Site 130
S1031
I
G
N
E
W
L
P
S
L
G
L
P
Q
Y
R
Site 131
Y1037
P
S
L
G
L
P
Q
Y
R
S
Y
F
M
E
C
Site 132
Y1040
G
L
P
Q
Y
R
S
Y
F
M
E
C
L
V
D
Site 133
T1055
A
R
M
L
D
H
L
T
K
K
D
L
R
V
H
Site 134
S1068
V
H
L
K
M
V
D
S
F
H
R
T
S
L
Q
Site 135
Y1076
F
H
R
T
S
L
Q
Y
G
I
M
C
L
K
R
Site 136
Y1086
M
C
L
K
R
L
N
Y
D
R
K
E
L
E
R
Site 137
S1098
L
E
R
R
R
E
A
S
Q
H
E
I
K
D
V
Site 138
Y1125
Q
A
I
G
L
R
E
Y
A
N
N
I
L
E
S
Site 139
Y1171
R
Q
I
L
E
R
E
Y
N
N
L
L
A
L
G
Site 140
T1179
N
N
L
L
A
L
G
T
E
R
R
L
D
E
S
Site 141
S1186
T
E
R
R
L
D
E
S
D
D
K
N
F
R
R
Site 142
S1195
D
K
N
F
R
R
G
S
T
W
R
R
Q
F
P
Site 143
T1196
K
N
F
R
R
G
S
T
W
R
R
Q
F
P
P
Site 144
S1210
P
R
E
V
H
G
I
S
M
M
P
G
S
S
E
Site 145
S1215
G
I
S
M
M
P
G
S
S
E
T
L
P
A
G
Site 146
S1216
I
S
M
M
P
G
S
S
E
T
L
P
A
G
F
Site 147
T1218
M
M
P
G
S
S
E
T
L
P
A
G
F
R
L
Site 148
T1226
L
P
A
G
F
R
L
T
T
T
S
G
Q
S
R
Site 149
T1227
P
A
G
F
R
L
T
T
T
S
G
Q
S
R
K
Site 150
T1228
A
G
F
R
L
T
T
T
S
G
Q
S
R
K
M
Site 151
S1229
G
F
R
L
T
T
T
S
G
Q
S
R
K
M
T
Site 152
T1236
S
G
Q
S
R
K
M
T
T
D
V
A
S
S
R
Site 153
T1237
G
Q
S
R
K
M
T
T
D
V
A
S
S
R
L
Site 154
S1241
K
M
T
T
D
V
A
S
S
R
L
Q
R
L
D
Site 155
S1250
R
L
Q
R
L
D
N
S
T
V
R
T
Y
S
C
Site 156
T1251
L
Q
R
L
D
N
S
T
V
R
T
Y
S
C
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation