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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
liprin alpha 4
Full Name:
Liprin-alpha-4
Alias:
LIPA4; Liprin-alpha4; PPFIA4; Protein tyrosine phosphatase receptor type f polypeptide-interacting alpha-4; Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) interacting protein (liprin) alpha 4; Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; PTPRF-interacting alpha-4
Type:
Adaptor/scaffold
Mass (Da):
78080
Number AA:
UniProt ID:
O75335
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
A
A
D
V
R
F
S
L
G
T
T
T
H
A
Site 2
T13
D
V
R
F
S
L
G
T
T
T
H
A
P
P
G
Site 3
T15
R
F
S
L
G
T
T
T
H
A
P
P
G
V
H
Site 4
Y25
P
P
G
V
H
R
R
Y
S
A
L
R
E
E
S
Site 5
S26
P
G
V
H
R
R
Y
S
A
L
R
E
E
S
A
Site 6
S32
Y
S
A
L
R
E
E
S
A
K
D
W
E
T
S
Site 7
T38
E
S
A
K
D
W
E
T
S
P
L
P
G
M
L
Site 8
S39
S
A
K
D
W
E
T
S
P
L
P
G
M
L
A
Site 9
S55
A
A
G
P
A
F
D
S
D
P
E
I
S
D
V
Site 10
S78
V
G
S
A
D
V
V
S
P
S
G
H
S
D
A
Site 11
S80
S
A
D
V
V
S
P
S
G
H
S
D
A
Q
T
Site 12
T87
S
G
H
S
D
A
Q
T
L
A
M
M
L
Q
E
Site 13
S112
M
I
Q
E
E
K
E
S
T
E
L
R
A
E
E
Site 14
T113
I
Q
E
E
K
E
S
T
E
L
R
A
E
E
I
Site 15
T122
L
R
A
E
E
I
E
T
R
V
T
S
G
S
M
Site 16
T125
E
E
I
E
T
R
V
T
S
G
S
M
E
A
L
Site 17
S126
E
I
E
T
R
V
T
S
G
S
M
E
A
L
N
Site 18
S128
E
T
R
V
T
S
G
S
M
E
A
L
N
L
K
Site 19
S142
K
Q
L
R
K
R
G
S
I
P
T
S
L
T
A
Site 20
T145
R
K
R
G
S
I
P
T
S
L
T
A
L
S
L
Site 21
S160
A
S
A
S
P
P
L
S
G
R
S
T
P
K
L
Site 22
S163
S
P
P
L
S
G
R
S
T
P
K
L
T
S
R
Site 23
T164
P
P
L
S
G
R
S
T
P
K
L
T
S
R
S
Site 24
T168
G
R
S
T
P
K
L
T
S
R
S
A
A
Q
D
Site 25
S169
R
S
T
P
K
L
T
S
R
S
A
A
Q
D
L
Site 26
T183
L
D
R
M
G
V
M
T
L
P
S
D
L
R
K
Site 27
S186
M
G
V
M
T
L
P
S
D
L
R
K
H
R
R
Site 28
S197
K
H
R
R
K
L
L
S
P
V
S
R
E
E
N
Site 29
S200
R
K
L
L
S
P
V
S
R
E
E
N
R
E
D
Site 30
T210
E
N
R
E
D
K
A
T
I
K
C
E
T
S
P
Site 31
T215
K
A
T
I
K
C
E
T
S
P
P
S
S
P
R
Site 32
S216
A
T
I
K
C
E
T
S
P
P
S
S
P
R
T
Site 33
S219
K
C
E
T
S
P
P
S
S
P
R
T
L
R
L
Site 34
S220
C
E
T
S
P
P
S
S
P
R
T
L
R
L
E
Site 35
T223
S
P
P
S
S
P
R
T
L
R
L
E
K
L
G
Site 36
S235
K
L
G
H
P
A
L
S
Q
E
E
G
K
S
A
Site 37
S241
L
S
Q
E
E
G
K
S
A
L
E
D
Q
G
S
Site 38
S248
S
A
L
E
D
Q
G
S
N
P
S
S
S
N
S
Site 39
S251
E
D
Q
G
S
N
P
S
S
S
N
S
S
Q
D
Site 40
S252
D
Q
G
S
N
P
S
S
S
N
S
S
Q
D
S
Site 41
S253
Q
G
S
N
P
S
S
S
N
S
S
Q
D
S
L
Site 42
S255
S
N
P
S
S
S
N
S
S
Q
D
S
L
H
K
Site 43
S256
N
P
S
S
S
N
S
S
Q
D
S
L
H
K
G
Site 44
S259
S
S
N
S
S
Q
D
S
L
H
K
G
A
K
R
Site 45
S271
A
K
R
K
G
I
K
S
S
I
G
R
L
F
G
Site 46
S272
K
R
K
G
I
K
S
S
I
G
R
L
F
G
K
Site 47
S289
K
G
R
L
I
Q
L
S
R
D
G
A
T
G
H
Site 48
T300
A
T
G
H
V
L
L
T
D
S
E
F
S
M
Q
Site 49
S302
G
H
V
L
L
T
D
S
E
F
S
M
Q
E
P
Site 50
S382
G
A
I
M
S
A
L
S
D
T
E
I
Q
R
E
Site 51
S393
I
Q
R
E
I
G
I
S
N
A
L
H
R
L
K
Site 52
S413
Q
E
M
V
S
L
T
S
P
S
A
P
P
T
S
Site 53
S415
M
V
S
L
T
S
P
S
A
P
P
T
S
R
T
Site 54
T419
T
S
P
S
A
P
P
T
S
R
T
S
S
G
N
Site 55
S420
S
P
S
A
P
P
T
S
R
T
S
S
G
N
V
Site 56
T422
S
A
P
P
T
S
R
T
S
S
G
N
V
W
V
Site 57
S423
A
P
P
T
S
R
T
S
S
G
N
V
W
V
T
Site 58
S424
P
P
T
S
R
T
S
S
G
N
V
W
V
T
H
Site 59
T436
V
T
H
E
E
M
E
T
L
E
T
S
T
K
T
Site 60
T439
E
E
M
E
T
L
E
T
S
T
K
T
D
S
E
Site 61
T443
T
L
E
T
S
T
K
T
D
S
E
E
G
S
W
Site 62
S445
E
T
S
T
K
T
D
S
E
E
G
S
W
A
Q
Site 63
S449
K
T
D
S
E
E
G
S
W
A
Q
T
L
A
Y
Site 64
T453
E
E
G
S
W
A
Q
T
L
A
Y
G
D
M
N
Site 65
S471
I
G
N
E
W
L
P
S
L
G
L
P
Q
Y
R
Site 66
Y477
P
S
L
G
L
P
Q
Y
R
S
Y
F
M
E
C
Site 67
Y480
G
L
P
Q
Y
R
S
Y
F
M
E
C
L
V
D
Site 68
T495
A
R
M
L
D
H
L
T
K
K
D
L
R
V
H
Site 69
S508
V
H
L
K
M
V
D
S
F
H
R
T
S
L
Q
Site 70
Y516
F
H
R
T
S
L
Q
Y
G
I
M
C
L
K
R
Site 71
Y526
M
C
L
K
R
L
N
Y
D
R
K
E
L
E
K
Site 72
S538
L
E
K
R
R
E
E
S
Q
H
E
I
K
D
V
Site 73
Y565
Q
S
I
G
L
R
D
Y
A
G
N
L
H
E
S
Site 74
T589
D
E
N
F
D
H
N
T
L
A
L
I
L
Q
I
Site 75
T619
N
N
L
L
A
L
G
T
D
R
K
L
D
D
G
Site 76
S636
K
V
F
R
R
A
P
S
W
R
K
R
F
R
P
Site 77
S654
H
G
R
G
G
M
L
S
A
S
A
E
T
L
P
Site 78
S656
R
G
G
M
L
S
A
S
A
E
T
L
P
A
G
Site 79
S667
L
P
A
G
F
R
V
S
T
L
G
T
L
Q
P
Site 80
T668
P
A
G
F
R
V
S
T
L
G
T
L
Q
P
P
Site 81
T671
F
R
V
S
T
L
G
T
L
Q
P
P
P
A
P
Site 82
Y690
M
P
E
A
H
S
H
Y
L
Y
G
H
M
L
S
Site 83
Y692
E
A
H
S
H
Y
L
Y
G
H
M
L
S
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation