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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF253
Full Name:
Zinc finger protein 253
Alias:
Bone marrow zinc finger 1;Zinc finger protein 411
Type:
Mass (Da):
57602
Number AA:
499
UniProt ID:
O75346
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
D
T
A
Q
R
N
L
Y
R
D
V
M
L
E
N
Site 2
S48
V
F
L
G
I
V
V
S
K
P
D
L
V
T
C
Site 3
T54
V
S
K
P
D
L
V
T
C
L
E
Q
G
K
K
Site 4
T64
E
Q
G
K
K
P
L
T
M
E
R
H
E
M
I
Site 5
Y102
Q
I
G
M
L
R
R
Y
E
E
C
R
H
D
N
Site 6
S118
Q
L
K
K
G
C
K
S
V
G
E
H
K
V
H
Site 7
T137
N
G
L
N
Q
C
L
T
T
T
Q
K
E
I
F
Site 8
Y149
E
I
F
Q
C
D
K
Y
G
K
V
F
H
K
F
Site 9
S157
G
K
V
F
H
K
F
S
N
S
N
T
Y
K
T
Site 10
T161
H
K
F
S
N
S
N
T
Y
K
T
R
H
T
G
Site 11
T167
N
T
Y
K
T
R
H
T
G
I
N
L
F
K
C
Site 12
S184
C
G
K
A
F
K
R
S
S
T
L
T
T
H
K
Site 13
S185
G
K
A
F
K
R
S
S
T
L
T
T
H
K
K
Site 14
T186
K
A
F
K
R
S
S
T
L
T
T
H
K
K
I
Site 15
T188
F
K
R
S
S
T
L
T
T
H
K
K
I
H
T
Site 16
T189
K
R
S
S
T
L
T
T
H
K
K
I
H
T
G
Site 17
T195
T
T
H
K
K
I
H
T
G
E
K
P
Y
R
C
Site 18
T216
F
N
Q
S
A
N
L
T
T
H
K
R
I
H
T
Site 19
T223
T
T
H
K
R
I
H
T
G
E
K
P
Y
R
C
Site 20
S240
C
G
K
A
F
K
Q
S
S
N
L
T
T
H
K
Site 21
S241
G
K
A
F
K
Q
S
S
N
L
T
T
H
K
K
Site 22
T244
F
K
Q
S
S
N
L
T
T
H
K
K
I
H
T
Site 23
T245
K
Q
S
S
N
L
T
T
H
K
K
I
H
T
G
Site 24
T251
T
T
H
K
K
I
H
T
G
E
K
P
Y
K
C
Site 25
S268
C
G
K
A
F
N
R
S
T
D
L
T
T
H
K
Site 26
T269
G
K
A
F
N
R
S
T
D
L
T
T
H
K
I
Site 27
T272
F
N
R
S
T
D
L
T
T
H
K
I
V
H
T
Site 28
T279
T
T
H
K
I
V
H
T
G
E
K
P
Y
K
C
Site 29
S297
G
K
A
F
K
H
P
S
H
V
T
T
H
K
K
Site 30
T301
K
H
P
S
H
V
T
T
H
K
K
I
H
T
R
Site 31
Y312
I
H
T
R
G
K
P
Y
N
C
E
E
C
G
K
Site 32
S325
G
K
S
F
K
H
C
S
N
L
T
I
H
K
R
Site 33
T335
T
I
H
K
R
I
H
T
G
E
K
P
Y
K
C
Site 34
S352
C
G
K
A
F
H
L
S
S
H
L
T
T
H
K
Site 35
S353
G
K
A
F
H
L
S
S
H
L
T
T
H
K
I
Site 36
T356
F
H
L
S
S
H
L
T
T
H
K
I
L
H
T
Site 37
T357
H
L
S
S
H
L
T
T
H
K
I
L
H
T
G
Site 38
Y368
L
H
T
G
E
K
P
Y
R
C
R
E
C
G
K
Site 39
S380
C
G
K
A
F
N
H
S
T
T
L
F
S
H
E
Site 40
T381
G
K
A
F
N
H
S
T
T
L
F
S
H
E
K
Site 41
T391
F
S
H
E
K
I
H
T
G
E
K
P
Y
K
C
Site 42
Y396
I
H
T
G
E
K
P
Y
K
C
D
E
C
G
K
Site 43
T406
D
E
C
G
K
T
F
T
W
P
S
I
L
S
K
Site 44
S409
G
K
T
F
T
W
P
S
I
L
S
K
H
K
R
Site 45
T417
I
L
S
K
H
K
R
T
H
T
G
E
K
P
Y
Site 46
T419
S
K
H
K
R
T
H
T
G
E
K
P
Y
K
C
Site 47
S432
K
C
E
E
C
G
K
S
F
T
A
S
S
T
L
Site 48
T434
E
E
C
G
K
S
F
T
A
S
S
T
L
T
T
Site 49
S436
C
G
K
S
F
T
A
S
S
T
L
T
T
H
K
Site 50
S437
G
K
S
F
T
A
S
S
T
L
T
T
H
K
R
Site 51
T438
K
S
F
T
A
S
S
T
L
T
T
H
K
R
I
Site 52
T440
F
T
A
S
S
T
L
T
T
H
K
R
I
H
T
Site 53
T441
T
A
S
S
T
L
T
T
H
K
R
I
H
T
G
Site 54
T447
T
T
H
K
R
I
H
T
G
E
K
P
Y
K
C
Site 55
S465
G
K
A
F
N
W
S
S
D
L
N
K
H
K
K
Site 56
Y480
I
H
I
E
R
K
P
Y
I
V
K
N
V
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation