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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS4B
Full Name:
Vacuolar protein sorting-associated protein 4B
Alias:
Cell migration-inducing 1; MIG1; SKD1; Suppressor of K(+) transport growth defect 1; Suppressor of K+ transport defect 1; VPS42; VPS4-2
Type:
Intracellular transport protein
Mass (Da):
49302
Number AA:
444
UniProt ID:
O75351
International Prot ID:
IPI00182728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005769
GO:0010008
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042623
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006200
GO:0007049
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
T
S
P
N
L
Q
Site 2
T4
_
_
_
_
M
S
S
T
S
P
N
L
Q
K
A
Site 3
S16
Q
K
A
I
D
L
A
S
K
A
A
Q
E
D
K
Site 4
Y34
Y
E
E
A
L
Q
L
Y
Q
H
A
V
Q
Y
F
Site 5
Y40
L
Y
Q
H
A
V
Q
Y
F
L
H
V
V
K
Y
Site 6
Y47
Y
F
L
H
V
V
K
Y
E
A
Q
G
D
K
A
Site 7
S57
Q
G
D
K
A
K
Q
S
I
R
A
K
C
T
E
Site 8
T63
Q
S
I
R
A
K
C
T
E
Y
L
D
R
A
E
Site 9
Y65
I
R
A
K
C
T
E
Y
L
D
R
A
E
K
L
Site 10
Y75
R
A
E
K
L
K
E
Y
L
K
N
K
E
K
K
Site 11
S93
P
V
K
E
G
Q
P
S
P
A
D
E
K
G
N
Site 12
S102
A
D
E
K
G
N
D
S
D
G
E
G
E
S
D
Site 13
S108
D
S
D
G
E
G
E
S
D
D
P
E
K
K
K
Site 14
S134
E
R
P
N
V
K
W
S
D
V
A
G
L
E
G
Site 15
T161
I
K
F
P
H
L
F
T
G
K
R
T
P
W
R
Site 16
T165
H
L
F
T
G
K
R
T
P
W
R
G
I
L
L
Site 17
T178
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
Site 18
S181
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
Site 19
Y182
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
Site 20
S194
V
A
T
E
A
N
N
S
T
F
F
S
I
S
S
Site 21
T195
A
T
E
A
N
N
S
T
F
F
S
I
S
S
S
Site 22
S200
N
S
T
F
F
S
I
S
S
S
D
L
V
S
K
Site 23
S206
I
S
S
S
D
L
V
S
K
W
L
G
E
S
E
Site 24
S238
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
Site 25
S242
E
I
D
S
L
C
G
S
R
S
E
N
E
S
E
Site 26
S244
D
S
L
C
G
S
R
S
E
N
E
S
E
A
A
Site 27
S248
G
S
R
S
E
N
E
S
E
A
A
R
R
I
K
Site 28
T256
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
Q
Site 29
S286
N
I
P
W
V
L
D
S
A
I
R
R
R
F
E
Site 30
Y297
R
R
F
E
K
R
I
Y
I
P
L
P
E
P
H
Site 31
T317
F
K
L
H
L
G
T
T
Q
N
S
L
T
E
A
Site 32
S320
H
L
G
T
T
Q
N
S
L
T
E
A
D
F
R
Site 33
T322
G
T
T
Q
N
S
L
T
E
A
D
F
R
E
L
Site 34
T333
F
R
E
L
G
R
K
T
D
G
Y
S
G
A
D
Site 35
Y336
L
G
R
K
T
D
G
Y
S
G
A
D
I
S
I
Site 36
S337
G
R
K
T
D
G
Y
S
G
A
D
I
S
I
I
Site 37
S342
G
Y
S
G
A
D
I
S
I
I
V
R
D
A
L
Site 38
S369
F
K
K
V
R
G
P
S
R
A
D
P
N
H
L
Site 39
T382
H
L
V
D
D
L
L
T
P
C
S
P
G
D
P
Site 40
S385
D
D
L
L
T
P
C
S
P
G
D
P
G
A
I
Site 41
S417
S
M
S
D
M
L
R
S
L
S
N
T
K
P
T
Site 42
S419
S
D
M
L
R
S
L
S
N
T
K
P
T
V
N
Site 43
T421
M
L
R
S
L
S
N
T
K
P
T
V
N
E
H
Site 44
T424
S
L
S
N
T
K
P
T
V
N
E
H
D
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation