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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENTPD6
Full Name:
Ectonucleoside triphosphate diphosphohydrolase 6
Alias:
CD39 antigen-like 2
Type:
Mass (Da):
53247
Number AA:
484
UniProt ID:
O75354
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
K
K
G
I
R
Y
E
T
S
R
K
T
S
Y
I
Site 2
S10
K
G
I
R
Y
E
T
S
R
K
T
S
Y
I
F
Site 3
T13
R
Y
E
T
S
R
K
T
S
Y
I
F
Q
Q
P
Site 4
S14
Y
E
T
S
R
K
T
S
Y
I
F
Q
Q
P
Q
Site 5
Y15
E
T
S
R
K
T
S
Y
I
F
Q
Q
P
Q
H
Site 6
S33
Q
T
R
M
R
K
I
S
N
H
G
S
L
R
V
Site 7
S37
R
K
I
S
N
H
G
S
L
R
V
A
K
V
A
Site 8
Y45
L
R
V
A
K
V
A
Y
P
L
G
L
C
V
G
Site 9
T68
K
W
H
R
A
T
A
T
Q
A
F
F
S
I
T
Site 10
S89
R
W
G
Q
Q
A
H
S
P
L
G
T
A
A
D
Site 11
T93
Q
A
H
S
P
L
G
T
A
A
D
G
H
E
V
Site 12
T121
R
V
H
V
F
Q
F
T
R
P
P
R
E
T
P
Site 13
T127
F
T
R
P
P
R
E
T
P
T
L
T
H
E
T
Site 14
T131
P
R
E
T
P
T
L
T
H
E
T
F
K
A
L
Site 15
S152
Y
A
D
D
V
E
K
S
A
Q
G
I
R
E
L
Site 16
S217
L
V
G
D
D
C
V
S
I
M
N
G
T
D
E
Site 17
S238
T
I
N
F
L
T
G
S
L
K
T
P
G
G
S
Site 18
T268
F
L
P
R
V
E
G
T
L
Q
A
S
P
P
G
Site 19
S272
V
E
G
T
L
Q
A
S
P
P
G
Y
L
T
A
Site 20
T278
A
S
P
P
G
Y
L
T
A
L
R
M
F
N
R
Site 21
T286
A
L
R
M
F
N
R
T
Y
K
L
Y
S
Y
S
Site 22
Y287
L
R
M
F
N
R
T
Y
K
L
Y
S
Y
S
Y
Site 23
Y290
F
N
R
T
Y
K
L
Y
S
Y
S
Y
L
G
L
Site 24
S291
N
R
T
Y
K
L
Y
S
Y
S
Y
L
G
L
G
Site 25
Y292
R
T
Y
K
L
Y
S
Y
S
Y
L
G
L
G
L
Site 26
S323
K
D
G
K
E
L
V
S
P
C
L
S
P
S
F
Site 27
S327
E
L
V
S
P
C
L
S
P
S
F
K
G
E
W
Site 28
S329
V
S
P
C
L
S
P
S
F
K
G
E
W
E
H
Site 29
T340
E
W
E
H
A
E
V
T
Y
R
V
S
G
Q
K
Site 30
S344
A
E
V
T
Y
R
V
S
G
Q
K
A
A
A
S
Site 31
Y380
E
V
K
H
V
D
F
Y
A
F
S
Y
Y
Y
D
Site 32
Y414
D
F
E
I
A
A
K
Y
V
C
R
T
L
E
T
Site 33
T421
Y
V
C
R
T
L
E
T
Q
P
Q
S
S
P
F
Site 34
S425
T
L
E
T
Q
P
Q
S
S
P
F
S
C
M
D
Site 35
S426
L
E
T
Q
P
Q
S
S
P
F
S
C
M
D
L
Site 36
S429
Q
P
Q
S
S
P
F
S
C
M
D
L
T
Y
V
Site 37
S448
Q
E
F
G
F
P
R
S
K
V
L
K
L
T
R
Site 38
S475
A
I
F
H
Y
I
D
S
L
N
R
Q
K
S
P
Site 39
S481
D
S
L
N
R
Q
K
S
P
A
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation