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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PITX3
Full Name:
Pituitary homeobox 3
Alias:
Homeobox protein PITX3; Paired-like homeodomain transcription factor 3; PTX3
Type:
Nucleus protein
Mass (Da):
31832
Number AA:
302
UniProt ID:
O75364
International Prot ID:
IPI00025313
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0009887
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
F
G
L
L
S
E
A
E
A
R
S
P
Site 2
S13
L
S
E
A
E
A
R
S
P
A
L
S
L
S
D
Site 3
S17
E
A
R
S
P
A
L
S
L
S
D
A
G
T
P
Site 4
S19
R
S
P
A
L
S
L
S
D
A
G
T
P
H
P
Site 5
T23
L
S
L
S
D
A
G
T
P
H
P
Q
L
P
E
Site 6
S39
G
C
K
G
Q
E
H
S
D
S
E
K
A
S
A
Site 7
S41
K
G
Q
E
H
S
D
S
E
K
A
S
A
S
L
Site 8
S45
H
S
D
S
E
K
A
S
A
S
L
P
G
G
S
Site 9
S47
D
S
E
K
A
S
A
S
L
P
G
G
S
P
E
Site 10
S52
S
A
S
L
P
G
G
S
P
E
D
G
S
L
K
Site 11
S57
G
G
S
P
E
D
G
S
L
K
K
K
Q
R
R
Site 12
T67
K
K
Q
R
R
Q
R
T
H
F
T
S
Q
Q
L
Site 13
S71
R
Q
R
T
H
F
T
S
Q
Q
L
Q
E
L
E
Site 14
T80
Q
L
Q
E
L
E
A
T
F
Q
R
N
R
Y
P
Site 15
Y86
A
T
F
Q
R
N
R
Y
P
D
M
S
T
R
E
Site 16
S90
R
N
R
Y
P
D
M
S
T
R
E
E
I
A
V
Site 17
S123
K
W
R
K
R
E
R
S
Q
Q
A
E
L
C
K
Site 18
Y144
L
G
G
L
V
P
P
Y
E
E
V
Y
P
G
Y
Site 19
Y148
V
P
P
Y
E
E
V
Y
P
G
Y
S
Y
G
N
Site 20
Y151
Y
E
E
V
Y
P
G
Y
S
Y
G
N
W
P
P
Site 21
S252
A
A
A
A
A
A
S
S
P
Y
V
Y
R
D
P
Site 22
Y254
A
A
A
A
S
S
P
Y
V
Y
R
D
P
C
N
Site 23
Y256
A
A
S
S
P
Y
V
Y
R
D
P
C
N
S
S
Site 24
S262
V
Y
R
D
P
C
N
S
S
L
A
S
L
R
L
Site 25
S263
Y
R
D
P
C
N
S
S
L
A
S
L
R
L
K
Site 26
S266
P
C
N
S
S
L
A
S
L
R
L
K
A
K
Q
Site 27
S276
L
K
A
K
Q
H
A
S
F
S
Y
P
A
V
H
Site 28
S278
A
K
Q
H
A
S
F
S
Y
P
A
V
H
G
P
Site 29
Y279
K
Q
H
A
S
F
S
Y
P
A
V
H
G
P
P
Site 30
S292
P
P
P
A
A
N
L
S
P
C
Q
Y
A
V
E
Site 31
Y296
A
N
L
S
P
C
Q
Y
A
V
E
R
P
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation