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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AVIL
Full Name:
Advillin
Alias:
p92
Type:
Cytoskeleton protein, Ca2+-regulated actin-binding protein
Mass (Da):
92028
Number AA:
819
UniProt ID:
O75366
International Prot ID:
IPI00289330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0007010
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y43
N
F
Y
E
G
D
C
Y
V
I
L
S
T
R
R
Site 2
S53
L
S
T
R
R
V
A
S
L
L
S
Q
D
I
H
Site 3
S68
F
W
I
G
K
D
S
S
Q
D
E
Q
S
C
A
Site 4
S73
D
S
S
Q
D
E
Q
S
C
A
A
I
Y
T
T
Site 5
Y78
E
Q
S
C
A
A
I
Y
T
T
Q
L
D
D
Y
Site 6
Y85
Y
T
T
Q
L
D
D
Y
L
G
G
S
P
V
Q
Site 7
S89
L
D
D
Y
L
G
G
S
P
V
Q
H
R
E
V
Site 8
T103
V
Q
Y
H
E
S
D
T
F
R
G
Y
F
K
Q
Site 9
Y107
E
S
D
T
F
R
G
Y
F
K
Q
G
I
I
Y
Site 10
Y131
K
H
V
E
T
N
T
Y
D
V
K
R
L
L
H
Site 11
T148
G
K
R
N
I
R
A
T
E
V
E
M
S
W
D
Site 12
S153
R
A
T
E
V
E
M
S
W
D
S
F
N
R
G
Site 13
S179
I
Q
W
N
G
P
E
S
N
S
G
E
R
L
K
Site 14
S216
E
G
D
K
E
A
A
S
P
E
L
M
K
V
L
Site 15
S231
Q
D
T
L
G
R
R
S
I
I
K
P
T
V
P
Site 16
T236
R
R
S
I
I
K
P
T
V
P
D
E
I
I
D
Site 17
Y253
Q
K
S
T
I
M
L
Y
H
I
S
D
S
A
G
Site 18
Y283
L
L
N
H
D
D
C
Y
I
L
D
Q
S
G
T
Site 19
Y293
D
Q
S
G
T
K
I
Y
V
W
K
G
K
G
A
Site 20
S310
A
E
K
Q
A
A
M
S
K
A
L
G
F
I
K
Site 21
S320
L
G
F
I
K
M
K
S
Y
P
S
S
T
N
V
Site 22
Y321
G
F
I
K
M
K
S
Y
P
S
S
T
N
V
E
Site 23
S324
K
M
K
S
Y
P
S
S
T
N
V
E
T
V
N
Site 24
T352
K
W
S
V
K
D
Q
T
M
G
L
G
K
T
F
Site 25
T375
F
Q
D
K
F
D
V
T
L
L
H
T
K
P
E
Site 26
Y415
V
P
V
E
Y
Q
W
Y
G
F
F
Y
G
G
D
Site 27
Y428
G
D
C
Y
L
V
L
Y
T
Y
E
V
N
G
K
Site 28
Y430
C
Y
L
V
L
Y
T
Y
E
V
N
G
K
P
H
Site 29
S449
I
W
Q
G
R
H
A
S
Q
D
E
L
A
A
S
Site 30
S456
S
Q
D
E
L
A
A
S
A
Y
Q
A
V
E
V
Site 31
Y458
D
E
L
A
A
S
A
Y
Q
A
V
E
V
D
R
Site 32
T480
Q
V
R
V
R
M
G
T
E
P
R
H
F
M
A
Site 33
S501
V
I
F
E
G
G
T
S
R
K
G
N
A
E
P
Site 34
S523
Q
I
H
G
N
D
K
S
N
T
K
A
V
E
V
Site 35
Y552
L
R
T
Q
A
E
H
Y
L
W
Y
G
K
G
S
Site 36
Y555
Q
A
E
H
Y
L
W
Y
G
K
G
S
S
G
D
Site 37
S578
A
S
L
L
C
D
G
S
E
N
T
V
A
E
G
Site 38
T581
L
C
D
G
S
E
N
T
V
A
E
G
Q
E
P
Site 39
T599
W
D
L
L
G
G
K
T
P
Y
A
N
D
K
R
Site 40
Y601
L
L
G
G
K
T
P
Y
A
N
D
K
R
L
Q
Site 41
S622
Q
S
R
L
F
E
C
S
N
K
T
G
Q
F
V
Site 42
T637
V
T
E
I
T
D
F
T
Q
D
D
L
N
P
T
Site 43
T666
I
G
A
E
A
N
A
T
E
K
E
S
A
L
A
Site 44
T674
E
K
E
S
A
L
A
T
A
Q
Q
Y
L
H
T
Site 45
Y678
A
L
A
T
A
Q
Q
Y
L
H
T
H
P
S
G
Site 46
S684
Q
Y
L
H
T
H
P
S
G
R
D
P
D
T
P
Site 47
T690
P
S
G
R
D
P
D
T
P
I
L
I
I
K
Q
Site 48
T721
N
I
W
S
A
G
K
T
Y
E
Q
L
K
E
E
Site 49
T746
T
A
D
M
K
N
A
T
L
S
L
N
S
N
D
Site 50
S748
D
M
K
N
A
T
L
S
L
N
S
N
D
S
E
Site 51
S754
L
S
L
N
S
N
D
S
E
P
K
Y
Y
P
I
Site 52
Y758
S
N
D
S
E
P
K
Y
Y
P
I
A
V
L
L
Site 53
Y759
N
D
S
E
P
K
Y
Y
P
I
A
V
L
L
K
Site 54
Y784
N
P
A
K
K
E
N
Y
L
S
E
Q
D
F
V
Site 55
S786
A
K
K
E
N
Y
L
S
E
Q
D
F
V
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation