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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
H2AFY
Full Name:
Core histone macro-H2A.1
Alias:
H2A histone family, member Y; H2A histone family, member Y isoform 2 variant; H2A.y; H2A/y; H2AF12M; H2AFJ; H2AY; Histone macroH2A1; MACROH2A1; MACROH2A1.1; MacroH2A1.2; Medulloblastoma antigen MU-MB-50.205; MH2A1
Type:
DNA binding protein
Mass (Da):
39617
Number AA:
372
UniProt ID:
O75367
International Prot ID:
IPI00744148
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001740
GO:0000786
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0007549
GO:0006334
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
R
G
G
K
K
K
S
T
K
T
S
R
S
A
Site 2
T11
R
G
G
K
K
K
S
T
K
T
S
R
S
A
K
Site 3
T13
G
K
K
K
S
T
K
T
S
R
S
A
K
A
G
Site 4
S14
K
K
K
S
T
K
T
S
R
S
A
K
A
G
V
Site 5
S16
K
S
T
K
T
S
R
S
A
K
A
G
V
I
F
Site 6
Y31
P
V
G
R
M
L
R
Y
I
K
K
G
H
P
K
Site 7
Y39
I
K
K
G
H
P
K
Y
R
I
G
V
G
A
P
Site 8
T77
D
N
K
K
G
R
V
T
P
R
H
I
L
L
A
Site 9
S120
L
L
A
K
K
R
G
S
K
G
K
L
E
A
I
Site 10
T129
G
K
L
E
A
I
I
T
P
P
P
A
K
K
A
Site 11
S138
P
P
A
K
K
A
K
S
P
S
Q
K
K
P
V
Site 12
S140
A
K
K
A
K
S
P
S
Q
K
K
P
V
S
K
Site 13
S146
P
S
Q
K
K
P
V
S
K
K
A
G
G
K
K
Site 14
S158
G
K
K
G
A
R
K
S
K
K
K
Q
G
E
V
Site 15
S166
K
K
K
Q
G
E
V
S
K
A
A
S
A
D
S
Site 16
S170
G
E
V
S
K
A
A
S
A
D
S
T
T
E
G
Site 17
S173
S
K
A
A
S
A
D
S
T
T
E
G
T
P
A
Site 18
T174
K
A
A
S
A
D
S
T
T
E
G
T
P
A
D
Site 19
T175
A
A
S
A
D
S
T
T
E
G
T
P
A
D
G
Site 20
T178
A
D
S
T
T
E
G
T
P
A
D
G
F
T
V
Site 21
S202
Q
K
L
N
L
I
H
S
E
I
S
N
L
A
G
Site 22
T232
L
K
D
D
L
G
N
T
L
E
K
K
G
G
K
Site 23
S308
A
D
D
K
K
L
K
S
I
A
F
P
S
I
G
Site 24
S313
L
K
S
I
A
F
P
S
I
G
S
G
R
N
G
Site 25
S316
I
A
F
P
S
I
G
S
G
R
N
G
F
P
K
Site 26
Y362
D
S
E
S
I
G
I
Y
V
Q
E
M
A
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation