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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLNB
Full Name:
Filamin-B
Alias:
ABP-278; ABP-280; Actin binding protein 278; Actin-binding protein ABP-278; Beta-filamin; Fh1; Filamin 3; Filamin B, beta; Filamin homolog 1; FLN1L; FLN-B; TABP; TAP; Thyroid autoantigen; Truncated actin-binding protein
Type:
Cytoskeletal protein, actin binding
Mass (Da):
278195
Number AA:
2602
UniProt ID:
O75369
International Prot ID:
IPI00289334
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
GO:0015629
GO:0005938
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0051015
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0030154
GO:0007016
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
G
N
L
Q
T
D
L
S
D
G
L
R
L
I
A
Site 2
S58
I
A
L
L
E
V
L
S
Q
K
R
M
Y
R
K
Site 3
Y63
V
L
S
Q
K
R
M
Y
R
K
Y
H
Q
R
P
Site 4
Y66
Q
K
R
M
Y
R
K
Y
H
Q
R
P
T
F
R
Site 5
T71
R
K
Y
H
Q
R
P
T
F
R
Q
M
Q
L
E
Site 6
T140
D
D
D
A
K
K
Q
T
P
K
Q
R
L
L
G
Site 7
Y155
W
I
Q
N
K
I
P
Y
L
P
I
T
N
F
N
Site 8
S229
H
P
D
V
D
E
H
S
V
M
T
Y
L
S
Q
Site 9
Y233
D
E
H
S
V
M
T
Y
L
S
Q
F
P
K
A
Site 10
S235
H
S
V
M
T
Y
L
S
Q
F
P
K
A
K
L
Site 11
Y260
N
P
K
K
A
R
A
Y
G
R
G
I
E
P
T
Site 12
T267
Y
G
R
G
I
E
P
T
G
N
M
V
K
Q
P
Site 13
T278
V
K
Q
P
A
K
F
T
V
D
T
I
S
A
G
Site 14
T281
P
A
K
F
T
V
D
T
I
S
A
G
Q
G
D
Site 15
T306
N
K
E
E
A
Q
V
T
P
D
S
D
K
N
K
Site 16
S309
E
A
Q
V
T
P
D
S
D
K
N
K
T
Y
S
Site 17
T314
P
D
S
D
K
N
K
T
Y
S
V
E
Y
L
P
Site 18
S316
S
D
K
N
K
T
Y
S
V
E
Y
L
P
K
V
Site 19
S339
L
F
A
G
Q
H
I
S
K
S
P
F
E
V
S
Site 20
S341
A
G
Q
H
I
S
K
S
P
F
E
V
S
V
D
Site 21
S346
S
K
S
P
F
E
V
S
V
D
K
A
Q
G
D
Site 22
S355
D
K
A
Q
G
D
A
S
K
V
T
A
K
G
P
Site 23
Y376
N
I
A
N
K
P
T
Y
F
D
I
Y
T
A
G
Site 24
T401
E
D
P
Q
G
K
N
T
V
E
L
L
V
E
D
Site 25
Y414
E
D
K
G
N
Q
V
Y
R
C
V
Y
K
P
M
Site 26
Y418
N
Q
V
Y
R
C
V
Y
K
P
M
Q
P
G
P
Site 27
S458
N
P
N
A
C
R
A
S
G
R
G
L
Q
P
K
Site 28
T472
K
G
V
R
I
R
E
T
T
D
F
K
V
D
T
Site 29
T473
G
V
R
I
R
E
T
T
D
F
K
V
D
T
K
Site 30
T479
T
T
D
F
K
V
D
T
K
A
A
G
S
G
E
Site 31
S484
V
D
T
K
A
A
G
S
G
E
L
G
V
T
M
Site 32
T490
G
S
G
E
L
G
V
T
M
K
G
P
K
G
L
Site 33
Y511
K
D
F
L
D
G
V
Y
A
F
E
Y
Y
P
S
Site 34
Y515
D
G
V
Y
A
F
E
Y
Y
P
S
T
P
G
R
Site 35
Y516
G
V
Y
A
F
E
Y
Y
P
S
T
P
G
R
Y
Site 36
S518
Y
A
F
E
Y
Y
P
S
T
P
G
R
Y
S
I
Site 37
T519
A
F
E
Y
Y
P
S
T
P
G
R
Y
S
I
A
Site 38
Y523
Y
P
S
T
P
G
R
Y
S
I
A
I
T
W
G
Site 39
S524
P
S
T
P
G
R
Y
S
I
A
I
T
W
G
G
Site 40
T528
G
R
Y
S
I
A
I
T
W
G
G
H
H
I
P
Site 41
S537
G
G
H
H
I
P
K
S
P
F
E
V
Q
V
G
Site 42
S567
H
G
G
I
V
G
R
S
A
D
F
V
V
E
S
Site 43
S590
G
F
A
I
E
G
P
S
Q
A
K
I
E
Y
N
Site 44
Y596
P
S
Q
A
K
I
E
Y
N
D
Q
N
D
G
S
Site 45
Y608
D
G
S
C
D
V
K
Y
W
P
K
E
P
G
E
Site 46
S630
D
D
E
D
I
K
D
S
P
Y
M
A
F
I
H
Site 47
Y632
E
D
I
K
D
S
P
Y
M
A
F
I
H
P
A
Site 48
T640
M
A
F
I
H
P
A
T
G
G
Y
N
P
D
L
Site 49
Y651
N
P
D
L
V
R
A
Y
G
P
G
L
E
K
S
Site 50
S658
Y
G
P
G
L
E
K
S
G
C
I
V
N
N
L
Site 51
T669
V
N
N
L
A
E
F
T
V
D
P
K
D
A
G
Site 52
T703
M
K
N
R
M
D
G
T
Y
A
C
S
Y
T
P
Site 53
Y704
K
N
R
M
D
G
T
Y
A
C
S
Y
T
P
V
Site 54
S707
M
D
G
T
Y
A
C
S
Y
T
P
V
K
A
I
Site 55
Y708
D
G
T
Y
A
C
S
Y
T
P
V
K
A
I
K
Site 56
T709
G
T
Y
A
C
S
Y
T
P
V
K
A
I
K
H
Site 57
S730
G
G
V
N
I
P
H
S
P
Y
R
V
N
I
G
Site 58
Y732
V
N
I
P
H
S
P
Y
R
V
N
I
G
Q
G
Site 59
S755
F
G
P
G
V
E
R
S
G
L
K
A
N
E
P
Site 60
T770
T
H
F
T
V
D
C
T
E
A
G
E
G
D
V
Site 61
S778
E
A
G
E
G
D
V
S
V
G
I
K
C
D
A
Site 62
S789
K
C
D
A
R
V
L
S
E
D
E
E
D
V
D
Site 63
T806
I
I
H
N
A
N
D
T
F
T
V
K
Y
V
P
Site 64
T808
H
N
A
N
D
T
F
T
V
K
Y
V
P
P
A
Site 65
Y811
N
D
T
F
T
V
K
Y
V
P
P
A
A
G
R
Site 66
S833
A
S
Q
E
I
P
A
S
P
F
R
V
K
V
D
Site 67
S842
F
R
V
K
V
D
P
S
H
D
A
S
K
V
K
Site 68
S846
V
D
P
S
H
D
A
S
K
V
K
A
E
G
P
Site 69
S856
K
A
E
G
P
G
L
S
K
A
G
V
E
N
G
Site 70
T869
N
G
K
P
T
H
F
T
V
Y
T
K
G
A
G
Site 71
Y871
K
P
T
H
F
T
V
Y
T
K
G
A
G
K
A
Site 72
S886
P
L
N
V
Q
F
N
S
P
L
P
G
D
A
V
Site 73
Y902
D
L
D
I
I
D
N
Y
D
Y
S
H
T
V
K
Site 74
Y904
D
I
I
D
N
Y
D
Y
S
H
T
V
K
Y
T
Site 75
T907
D
N
Y
D
Y
S
H
T
V
K
Y
T
P
T
Q
Site 76
Y910
D
Y
S
H
T
V
K
Y
T
P
T
Q
Q
G
N
Site 77
T911
Y
S
H
T
V
K
Y
T
P
T
Q
Q
G
N
M
Site 78
S932
G
G
D
P
I
P
K
S
P
F
T
V
G
V
A
Site 79
T965
V
G
K
D
Q
E
F
T
V
D
T
R
G
A
G
Site 80
T968
D
Q
E
F
T
V
D
T
R
G
A
G
G
Q
G
Site 81
T980
G
Q
G
K
L
D
V
T
I
L
S
P
S
R
K
Site 82
S983
K
L
D
V
T
I
L
S
P
S
R
K
V
V
P
Site 83
S985
D
V
T
I
L
S
P
S
R
K
V
V
P
C
L
Site 84
T994
K
V
V
P
C
L
V
T
P
V
T
G
R
E
N
Site 85
T997
P
C
L
V
T
P
V
T
G
R
E
N
S
T
A
Site 86
S1002
P
V
T
G
R
E
N
S
T
A
K
F
I
P
R
Site 87
Y1014
I
P
R
E
E
G
L
Y
A
V
D
V
T
Y
D
Site 88
Y1020
L
Y
A
V
D
V
T
Y
D
G
H
P
V
P
G
Site 89
S1028
D
G
H
P
V
P
G
S
P
Y
T
V
E
A
S
Site 90
T1031
P
V
P
G
S
P
Y
T
V
E
A
S
L
P
P
Site 91
S1035
S
P
Y
T
V
E
A
S
L
P
P
D
P
S
K
Site 92
S1041
A
S
L
P
P
D
P
S
K
V
K
A
H
G
P
Site 93
T1062
V
G
K
P
A
E
F
T
I
D
T
K
G
A
G
Site 94
T1065
P
A
E
F
T
I
D
T
K
G
A
G
T
G
G
Site 95
T1094
C
S
D
N
G
D
G
T
C
S
V
S
Y
L
P
Site 96
S1096
D
N
G
D
G
T
C
S
V
S
Y
L
P
T
K
Site 97
S1098
G
D
G
T
C
S
V
S
Y
L
P
T
K
P
G
Site 98
Y1099
D
G
T
C
S
V
S
Y
L
P
T
K
P
G
E
Site 99
T1102
C
S
V
S
Y
L
P
T
K
P
G
E
Y
F
V
Site 100
S1121
E
E
V
H
I
P
G
S
P
F
K
A
D
I
E
Site 101
S1134
I
E
M
P
F
D
P
S
K
V
V
A
S
G
P
Site 102
S1139
D
P
S
K
V
V
A
S
G
P
G
L
E
H
G
Site 103
S1172
A
L
G
L
E
A
V
S
D
S
G
T
K
A
E
Site 104
T1176
E
A
V
S
D
S
G
T
K
A
E
V
S
I
Q
Site 105
S1181
S
G
T
K
A
E
V
S
I
Q
N
N
K
D
G
Site 106
Y1190
Q
N
N
K
D
G
T
Y
A
V
T
Y
V
P
L
Site 107
T1198
A
V
T
Y
V
P
L
T
A
G
M
Y
T
L
T
Site 108
T1203
P
L
T
A
G
M
Y
T
L
T
M
K
Y
G
G
Site 109
T1205
T
A
G
M
Y
T
L
T
M
K
Y
G
G
E
L
Site 110
T1248
K
D
V
F
R
E
A
T
T
D
F
T
V
D
S
Site 111
T1252
R
E
A
T
T
D
F
T
V
D
S
R
P
L
T
Site 112
S1255
T
T
D
F
T
V
D
S
R
P
L
T
Q
V
G
Site 113
T1259
T
V
D
S
R
P
L
T
Q
V
G
G
D
H
I
Site 114
S1274
K
A
H
I
A
N
P
S
G
A
S
T
E
C
F
Site 115
T1278
A
N
P
S
G
A
S
T
E
C
F
V
T
D
N
Site 116
T1283
A
S
T
E
C
F
V
T
D
N
A
D
G
T
Y
Site 117
T1289
V
T
D
N
A
D
G
T
Y
Q
V
E
Y
T
P
Site 118
Y1290
T
D
N
A
D
G
T
Y
Q
V
E
Y
T
P
F
Site 119
Y1294
D
G
T
Y
Q
V
E
Y
T
P
F
E
K
G
L
Site 120
T1295
G
T
Y
Q
V
E
Y
T
P
F
E
K
G
L
H
Site 121
T1307
G
L
H
V
V
E
V
T
Y
D
D
V
P
I
P
Site 122
S1316
D
D
V
P
I
P
N
S
P
F
K
V
A
V
T
Site 123
T1323
S
P
F
K
V
A
V
T
E
G
C
Q
P
S
R
Site 124
T1343
P
G
L
K
E
A
F
T
N
K
P
N
V
F
T
Site 125
T1350
T
N
K
P
N
V
F
T
V
V
T
R
G
A
G
Site 126
S1369
G
I
T
V
E
G
P
S
E
S
K
I
N
C
R
Site 127
Y1387
D
G
S
C
S
A
E
Y
I
P
F
A
P
G
D
Site 128
Y1395
I
P
F
A
P
G
D
Y
D
V
N
I
T
Y
G
Site 129
S1409
G
G
A
H
I
P
G
S
P
F
R
V
P
V
K
Site 130
S1422
V
K
D
V
V
D
P
S
K
V
K
I
A
G
P
Site 131
S1433
I
A
G
P
G
L
G
S
G
V
R
A
R
V
L
Site 132
S1442
V
R
A
R
V
L
Q
S
F
T
V
D
S
S
K
Site 133
T1444
A
R
V
L
Q
S
F
T
V
D
S
S
K
A
G
Site 134
S1447
L
Q
S
F
T
V
D
S
S
K
A
G
L
A
P
Site 135
S1448
Q
S
F
T
V
D
S
S
K
A
G
L
A
P
L
Site 136
T1478
M
V
D
N
G
D
G
T
H
T
V
T
Y
T
P
Site 137
T1480
D
N
G
D
G
T
H
T
V
T
Y
T
P
S
Q
Site 138
T1482
G
D
G
T
H
T
V
T
Y
T
P
S
Q
E
G
Site 139
Y1483
D
G
T
H
T
V
T
Y
T
P
S
Q
E
G
P
Site 140
T1484
G
T
H
T
V
T
Y
T
P
S
Q
E
G
P
Y
Site 141
S1486
H
T
V
T
Y
T
P
S
Q
E
G
P
Y
M
V
Site 142
Y1497
P
Y
M
V
S
V
K
Y
A
D
E
E
I
P
R
Site 143
S1505
A
D
E
E
I
P
R
S
P
F
K
V
K
V
L
Site 144
Y1515
K
V
K
V
L
P
T
Y
D
A
S
K
V
T
A
Site 145
S1523
D
A
S
K
V
T
A
S
G
P
G
L
S
S
Y
Site 146
S1528
T
A
S
G
P
G
L
S
S
Y
G
V
P
A
S
Site 147
Y1530
S
G
P
G
L
S
S
Y
G
V
P
A
S
L
P
Site 148
S1535
S
S
Y
G
V
P
A
S
L
P
V
D
F
A
I
Site 149
T1557
G
L
L
A
V
Q
I
T
D
Q
E
G
K
P
K
Site 150
T1575
V
H
D
N
K
D
G
T
Y
A
V
T
Y
I
P
Site 151
Y1576
H
D
N
K
D
G
T
Y
A
V
T
Y
I
P
D
Site 152
T1579
K
D
G
T
Y
A
V
T
Y
I
P
D
K
T
G
Site 153
Y1580
D
G
T
Y
A
V
T
Y
I
P
D
K
T
G
R
Site 154
T1585
V
T
Y
I
P
D
K
T
G
R
Y
M
I
G
V
Site 155
Y1588
I
P
D
K
T
G
R
Y
M
I
G
V
T
Y
G
Site 156
S1602
G
G
D
D
I
P
L
S
P
Y
R
I
R
A
T
Site 157
T1609
S
P
Y
R
I
R
A
T
Q
T
G
D
A
S
K
Site 158
S1615
A
T
Q
T
G
D
A
S
K
C
L
A
T
G
P
Site 159
S1626
A
T
G
P
G
I
A
S
T
V
K
T
G
E
E
Site 160
T1627
T
G
P
G
I
A
S
T
V
K
T
G
E
E
V
Site 161
T1651
G
K
G
K
V
T
C
T
V
L
T
P
D
G
T
Site 162
T1654
K
V
T
C
T
V
L
T
P
D
G
T
E
A
E
Site 163
T1671
V
I
E
N
E
D
G
T
Y
D
I
F
Y
T
A
Site 164
Y1672
I
E
N
E
D
G
T
Y
D
I
F
Y
T
A
A
Site 165
Y1676
D
G
T
Y
D
I
F
Y
T
A
A
K
P
G
T
Site 166
T1677
G
T
Y
D
I
F
Y
T
A
A
K
P
G
T
Y
Site 167
Y1684
T
A
A
K
P
G
T
Y
V
I
Y
V
R
F
G
Site 168
Y1687
K
P
G
T
Y
V
I
Y
V
R
F
G
G
V
D
Site 169
T1701
D
I
P
N
S
P
F
T
V
M
A
T
D
G
E
Site 170
Y1733
P
W
V
T
E
E
A
Y
V
P
V
S
D
M
N
Site 171
S1737
E
E
A
Y
V
P
V
S
D
M
N
G
L
G
F
Site 172
T1761
A
V
R
K
G
E
I
T
G
E
V
H
M
P
S
Site 173
T1773
M
P
S
G
K
T
A
T
P
E
I
V
D
N
K
Site 174
T1783
I
V
D
N
K
D
G
T
V
T
V
R
Y
A
P
Site 175
T1785
D
N
K
D
G
T
V
T
V
R
Y
A
P
T
E
Site 176
T1791
V
T
V
R
Y
A
P
T
E
V
G
L
H
E
M
Site 177
Y1802
L
H
E
M
H
I
K
Y
M
G
S
H
I
P
E
Site 178
S1810
M
G
S
H
I
P
E
S
P
L
Q
F
Y
V
N
Site 179
Y1815
P
E
S
P
L
Q
F
Y
V
N
Y
P
N
S
G
Site 180
Y1818
P
L
Q
F
Y
V
N
Y
P
N
S
G
S
V
S
Site 181
S1821
F
Y
V
N
Y
P
N
S
G
S
V
S
A
Y
G
Site 182
S1823
V
N
Y
P
N
S
G
S
V
S
A
Y
G
P
G
Site 183
S1825
Y
P
N
S
G
S
V
S
A
Y
G
P
G
L
V
Site 184
Y1827
N
S
G
S
V
S
A
Y
G
P
G
L
V
Y
G
Site 185
T1875
C
I
D
N
K
D
G
T
C
T
V
T
Y
L
P
Site 186
T1877
D
N
K
D
G
T
C
T
V
T
Y
L
P
T
L
Site 187
T1879
K
D
G
T
C
T
V
T
Y
L
P
T
L
P
G
Site 188
Y1880
D
G
T
C
T
V
T
Y
L
P
T
L
P
G
D
Site 189
S1889
P
T
L
P
G
D
Y
S
I
L
V
K
Y
N
D
Site 190
Y1894
D
Y
S
I
L
V
K
Y
N
D
K
H
I
P
G
Site 191
S1902
N
D
K
H
I
P
G
S
P
F
T
A
K
I
T
Site 192
S1912
T
A
K
I
T
D
D
S
R
R
C
S
Q
V
K
Site 193
S1916
T
D
D
S
R
R
C
S
Q
V
K
L
G
S
A
Site 194
S1922
C
S
Q
V
K
L
G
S
A
A
D
F
L
L
D
Site 195
S1936
D
I
S
E
T
D
L
S
S
L
T
A
S
I
K
Site 196
S1937
I
S
E
T
D
L
S
S
L
T
A
S
I
K
A
Site 197
S1941
D
L
S
S
L
T
A
S
I
K
A
P
S
G
R
Site 198
S1946
T
A
S
I
K
A
P
S
G
R
D
E
P
C
L
Site 199
S1965
P
N
N
H
I
G
I
S
F
I
P
R
E
V
G
Site 200
S1977
E
V
G
E
H
L
V
S
I
K
K
N
G
N
H
Site 201
S1988
N
G
N
H
V
A
N
S
P
V
S
I
M
V
V
Site 202
S1997
V
S
I
M
V
V
Q
S
E
I
G
D
A
R
R
Site 203
Y2008
D
A
R
R
A
K
V
Y
G
R
G
L
S
E
G
Site 204
S2013
K
V
Y
G
R
G
L
S
E
G
R
T
F
E
M
Site 205
T2017
R
G
L
S
E
G
R
T
F
E
M
S
D
F
I
Site 206
S2021
E
G
R
T
F
E
M
S
D
F
I
V
D
T
R
Site 207
T2027
M
S
D
F
I
V
D
T
R
D
A
G
Y
G
G
Site 208
S2036
D
A
G
Y
G
G
I
S
L
A
V
E
G
P
S
Site 209
T2049
P
S
K
V
D
I
Q
T
E
D
L
E
D
G
T
Site 210
T2056
T
E
D
L
E
D
G
T
C
K
V
S
Y
F
P
Site 211
S2060
E
D
G
T
C
K
V
S
Y
F
P
T
V
P
G
Site 212
S2083
A
D
E
H
V
P
G
S
P
F
T
V
K
I
S
Site 213
T2086
H
V
P
G
S
P
F
T
V
K
I
S
G
E
G
Site 214
S2098
G
E
G
R
V
K
E
S
I
T
R
T
S
R
A
Site 215
T2102
V
K
E
S
I
T
R
T
S
R
A
P
S
V
A
Site 216
S2103
K
E
S
I
T
R
T
S
R
A
P
S
V
A
T
Site 217
S2107
T
R
T
S
R
A
P
S
V
A
T
V
G
S
I
Site 218
S2113
P
S
V
A
T
V
G
S
I
C
D
L
N
L
K
Site 219
S2126
L
K
I
P
E
I
N
S
S
D
M
S
A
H
V
Site 220
S2127
K
I
P
E
I
N
S
S
D
M
S
A
H
V
T
Site 221
S2130
E
I
N
S
S
D
M
S
A
H
V
T
S
P
S
Site 222
T2134
S
D
M
S
A
H
V
T
S
P
S
G
R
V
T
Site 223
S2135
D
M
S
A
H
V
T
S
P
S
G
R
V
T
E
Site 224
S2137
S
A
H
V
T
S
P
S
G
R
V
T
E
A
E
Site 225
T2141
T
S
P
S
G
R
V
T
E
A
E
I
V
P
M
Site 226
T2166
P
Q
E
M
G
V
H
T
V
S
V
K
Y
R
G
Site 227
T2177
K
Y
R
G
Q
H
V
T
G
S
P
F
Q
F
T
Site 228
S2179
R
G
Q
H
V
T
G
S
P
F
Q
F
T
V
G
Site 229
T2184
T
G
S
P
F
Q
F
T
V
G
P
L
G
E
G
Site 230
S2215
A
G
V
P
A
E
F
S
I
W
T
R
E
A
G
Site 231
T2239
G
P
S
K
A
E
I
T
F
D
D
H
K
N
G
Site 232
S2251
K
N
G
S
C
G
V
S
Y
I
A
Q
E
P
G
Site 233
Y2252
N
G
S
C
G
V
S
Y
I
A
Q
E
P
G
N
Site 234
Y2260
I
A
Q
E
P
G
N
Y
E
V
S
I
K
F
N
Site 235
S2274
N
D
E
H
I
P
E
S
P
Y
L
V
P
V
I
Site 236
Y2276
E
H
I
P
E
S
P
Y
L
V
P
V
I
A
P
Site 237
S2284
L
V
P
V
I
A
P
S
D
D
A
R
R
L
T
Site 238
T2291
S
D
D
A
R
R
L
T
V
M
S
L
Q
E
S
Site 239
S2294
A
R
R
L
T
V
M
S
L
Q
E
S
G
L
K
Site 240
S2298
T
V
M
S
L
Q
E
S
G
L
K
V
N
Q
P
Site 241
S2307
L
K
V
N
Q
P
A
S
F
A
I
R
L
N
G
Site 242
S2325
K
I
D
A
K
V
H
S
P
S
G
A
V
E
E
Site 243
S2327
D
A
K
V
H
S
P
S
G
A
V
E
E
C
H
Site 244
S2336
A
V
E
E
C
H
V
S
E
L
E
P
D
K
Y
Site 245
Y2343
S
E
L
E
P
D
K
Y
A
V
R
F
I
P
H
Site 246
S2369
N
G
S
H
V
V
G
S
P
F
K
V
R
V
G
Site 247
T2399
T
G
L
E
G
G
T
T
G
I
Q
S
E
F
F
Site 248
S2403
G
G
T
T
G
I
Q
S
E
F
F
I
N
T
T
Site 249
T2409
Q
S
E
F
F
I
N
T
T
R
A
G
P
G
T
Site 250
T2410
S
E
F
F
I
N
T
T
R
A
G
P
G
T
L
Site 251
T2416
T
T
R
A
G
P
G
T
L
S
V
T
I
E
G
Site 252
S2418
R
A
G
P
G
T
L
S
V
T
I
E
G
P
S
Site 253
T2420
G
P
G
T
L
S
V
T
I
E
G
P
S
K
V
Site 254
S2425
S
V
T
I
E
G
P
S
K
V
K
M
D
C
Q
Site 255
T2434
V
K
M
D
C
Q
E
T
P
E
G
Y
K
V
M
Site 256
Y2438
C
Q
E
T
P
E
G
Y
K
V
M
Y
T
P
M
Site 257
Y2442
P
E
G
Y
K
V
M
Y
T
P
M
A
P
G
N
Site 258
T2443
E
G
Y
K
V
M
Y
T
P
M
A
P
G
N
Y
Site 259
Y2450
T
P
M
A
P
G
N
Y
L
I
S
V
K
Y
G
Site 260
S2453
A
P
G
N
Y
L
I
S
V
K
Y
G
G
P
N
Site 261
Y2456
N
Y
L
I
S
V
K
Y
G
G
P
N
H
I
V
Site 262
S2465
G
P
N
H
I
V
G
S
P
F
K
A
K
V
T
Site 263
T2472
S
P
F
K
A
K
V
T
G
Q
R
L
V
S
P
Site 264
S2478
V
T
G
Q
R
L
V
S
P
G
S
A
N
E
T
Site 265
S2481
Q
R
L
V
S
P
G
S
A
N
E
T
S
S
I
Site 266
T2485
S
P
G
S
A
N
E
T
S
S
I
L
V
E
S
Site 267
S2487
G
S
A
N
E
T
S
S
I
L
V
E
S
V
T
Site 268
S2492
T
S
S
I
L
V
E
S
V
T
R
S
S
T
E
Site 269
T2494
S
I
L
V
E
S
V
T
R
S
S
T
E
T
C
Site 270
S2496
L
V
E
S
V
T
R
S
S
T
E
T
C
Y
S
Site 271
S2497
V
E
S
V
T
R
S
S
T
E
T
C
Y
S
A
Site 272
T2498
E
S
V
T
R
S
S
T
E
T
C
Y
S
A
I
Site 273
T2500
V
T
R
S
S
T
E
T
C
Y
S
A
I
P
K
Site 274
Y2502
R
S
S
T
E
T
C
Y
S
A
I
P
K
A
S
Site 275
S2503
S
S
T
E
T
C
Y
S
A
I
P
K
A
S
S
Site 276
S2510
S
A
I
P
K
A
S
S
D
A
S
K
V
T
S
Site 277
S2513
P
K
A
S
S
D
A
S
K
V
T
S
K
G
A
Site 278
S2517
S
D
A
S
K
V
T
S
K
G
A
G
L
S
K
Site 279
S2523
T
S
K
G
A
G
L
S
K
A
F
V
G
Q
K
Site 280
S2542
V
D
C
S
K
A
G
S
N
M
L
L
I
G
V
Site 281
T2553
L
I
G
V
H
G
P
T
T
P
C
E
E
V
S
Site 282
T2554
I
G
V
H
G
P
T
T
P
C
E
E
V
S
M
Site 283
S2560
T
T
P
C
E
E
V
S
M
K
H
V
G
N
Q
Site 284
Y2569
K
H
V
G
N
Q
Q
Y
N
V
T
Y
V
V
K
Site 285
Y2573
N
Q
Q
Y
N
V
T
Y
V
V
K
E
R
G
D
Site 286
Y2581
V
V
K
E
R
G
D
Y
V
L
A
V
K
W
G
Site 287
S2595
G
E
E
H
I
P
G
S
P
F
H
V
T
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation