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Updated November 2019
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Protein Info
Short Name:
NCOR1
Full Name:
Nuclear receptor corepressor 1
Alias:
KIAA1047; MGC104216; N-CoR; Nuclear receptor co-repressor 1; Thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
270210
Number AA:
2440
UniProt ID:
O75376
International Prot ID:
IPI00289344
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005876
GO:0017053
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0042826
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0046329
GO:0010553
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
P
N
Q
G
A
F
S
T
E
Q
S
R
Y
P
Site 2
S18
G
A
F
S
T
E
Q
S
R
Y
P
P
H
S
V
Site 3
Y20
F
S
T
E
Q
S
R
Y
P
P
H
S
V
Q
Y
Site 4
S24
Q
S
R
Y
P
P
H
S
V
Q
Y
T
F
P
N
Site 5
Y27
Y
P
P
H
S
V
Q
Y
T
F
P
N
T
R
H
Site 6
T28
P
P
H
S
V
Q
Y
T
F
P
N
T
R
H
Q
Site 7
Y43
Q
E
F
A
V
P
D
Y
R
S
S
H
L
E
V
Site 8
S46
A
V
P
D
Y
R
S
S
H
L
E
V
S
Q
A
Site 9
S51
R
S
S
H
L
E
V
S
Q
A
S
Q
L
L
Q
Site 10
S70
Q
Q
L
R
R
R
P
S
L
L
S
E
F
H
P
Site 11
S73
R
R
R
P
S
L
L
S
E
F
H
P
G
S
D
Site 12
S79
L
S
E
F
H
P
G
S
D
R
P
Q
E
R
R
Site 13
T87
D
R
P
Q
E
R
R
T
S
Y
E
P
F
H
P
Site 14
S88
R
P
Q
E
R
R
T
S
Y
E
P
F
H
P
G
Site 15
Y89
P
Q
E
R
R
T
S
Y
E
P
F
H
P
G
P
Site 16
S97
E
P
F
H
P
G
P
S
P
V
D
H
D
S
L
Site 17
S103
P
S
P
V
D
H
D
S
L
E
S
K
R
P
R
Site 18
S106
V
D
H
D
S
L
E
S
K
R
P
R
L
E
Q
Site 19
S115
R
P
R
L
E
Q
V
S
D
S
H
F
Q
R
V
Site 20
S117
R
L
E
Q
V
S
D
S
H
F
Q
R
V
S
A
Site 21
S140
L
P
E
G
L
R
A
S
A
D
A
K
K
D
P
Site 22
S157
G
G
K
H
E
A
P
S
S
P
I
S
G
Q
P
Site 23
S158
G
K
H
E
A
P
S
S
P
I
S
G
Q
P
C
Site 24
S161
E
A
P
S
S
P
I
S
G
Q
P
C
G
D
D
Site 25
S172
C
G
D
D
Q
N
A
S
P
S
K
L
S
K
E
Site 26
S184
S
K
E
E
L
I
Q
S
M
D
R
V
D
R
E
Site 27
S224
P
E
P
E
K
P
V
S
P
P
P
V
E
Q
K
Site 28
Y240
R
S
I
V
Q
I
I
Y
D
E
N
R
K
K
A
Site 29
Y266
P
K
V
E
L
P
L
Y
N
Q
P
S
D
T
K
Site 30
S270
L
P
L
Y
N
Q
P
S
D
T
K
V
Y
H
E
Site 31
Y275
Q
P
S
D
T
K
V
Y
H
E
N
I
K
T
N
Site 32
T281
V
Y
H
E
N
I
K
T
N
Q
V
M
R
K
K
Site 33
S336
P
R
R
K
A
K
E
S
K
T
R
E
Y
Y
E
Site 34
Y341
K
E
S
K
T
R
E
Y
Y
E
K
Q
F
P
E
Site 35
Y342
E
S
K
T
R
E
Y
Y
E
K
Q
F
P
E
I
Site 36
S370
G
Q
R
G
A
G
L
S
A
T
I
A
R
S
E
Site 37
T372
R
G
A
G
L
S
A
T
I
A
R
S
E
H
E
Site 38
S376
L
S
A
T
I
A
R
S
E
H
E
I
S
E
I
Site 39
S381
A
R
S
E
H
E
I
S
E
I
I
D
G
L
S
Site 40
S388
S
E
I
I
D
G
L
S
E
Q
E
N
N
E
K
Site 41
S401
E
K
Q
M
R
Q
L
S
V
I
P
P
M
M
F
Site 42
S464
K
N
F
G
L
I
A
S
Y
L
E
R
K
S
V
Site 43
Y465
N
F
G
L
I
A
S
Y
L
E
R
K
S
V
P
Site 44
S470
A
S
Y
L
E
R
K
S
V
P
D
C
V
L
Y
Site 45
Y477
S
V
P
D
C
V
L
Y
Y
Y
L
T
K
K
N
Site 46
Y479
P
D
C
V
L
Y
Y
Y
L
T
K
K
N
E
N
Site 47
Y495
K
A
L
V
R
R
N
Y
G
K
R
R
G
R
N
Site 48
S509
N
Q
Q
I
A
R
P
S
Q
E
E
K
V
E
E
Site 49
S544
E
K
D
E
K
E
D
S
K
E
N
T
K
E
K
Site 50
T548
K
E
D
S
K
E
N
T
K
E
K
D
K
I
D
Site 51
T557
E
K
D
K
I
D
G
T
A
E
E
T
E
E
R
Site 52
T568
T
E
E
R
E
Q
A
T
P
R
G
R
K
T
A
Site 53
T574
A
T
P
R
G
R
K
T
A
N
S
Q
G
R
R
Site 54
S577
R
G
R
K
T
A
N
S
Q
G
R
R
K
G
R
Site 55
T586
G
R
R
K
G
R
I
T
R
S
M
T
N
E
A
Site 56
S588
R
K
G
R
I
T
R
S
M
T
N
E
A
A
A
Site 57
T590
G
R
I
T
R
S
M
T
N
E
A
A
A
A
S
Site 58
T604
S
A
A
A
A
A
A
T
E
E
P
P
P
P
L
Site 59
S619
P
P
P
P
E
P
I
S
T
E
P
V
E
T
S
Site 60
T620
P
P
P
E
P
I
S
T
E
P
V
E
T
S
R
Site 61
T625
I
S
T
E
P
V
E
T
S
R
W
T
E
E
E
Site 62
T629
P
V
E
T
S
R
W
T
E
E
E
M
E
V
A
Site 63
S658
A
K
M
V
G
T
K
S
E
A
Q
C
K
N
F
Site 64
Y666
E
A
Q
C
K
N
F
Y
F
N
Y
K
R
R
H
Site 65
Y669
C
K
N
F
Y
F
N
Y
K
R
R
H
N
L
D
Site 66
T686
L
Q
Q
H
K
Q
K
T
S
R
K
P
R
E
E
Site 67
S697
P
R
E
E
R
D
V
S
Q
C
E
S
V
A
S
Site 68
S701
R
D
V
S
Q
C
E
S
V
A
S
T
V
S
A
Site 69
S704
S
Q
C
E
S
V
A
S
T
V
S
A
Q
E
D
Site 70
T705
Q
C
E
S
V
A
S
T
V
S
A
Q
E
D
E
Site 71
S726
E
E
E
N
P
E
D
S
E
V
E
A
V
K
P
Site 72
S737
A
V
K
P
S
E
D
S
P
E
N
A
T
S
R
Site 73
T747
N
A
T
S
R
G
N
T
E
P
A
V
E
L
E
Site 74
T756
P
A
V
E
L
E
P
T
T
E
T
A
P
S
T
Site 75
S762
P
T
T
E
T
A
P
S
T
S
P
S
L
A
V
Site 76
S764
T
E
T
A
P
S
T
S
P
S
L
A
V
P
S
Site 77
S766
T
A
P
S
T
S
P
S
L
A
V
P
S
T
K
Site 78
T772
P
S
L
A
V
P
S
T
K
P
A
E
D
E
S
Site 79
S779
T
K
P
A
E
D
E
S
V
E
T
Q
V
N
D
Site 80
T782
A
E
D
E
S
V
E
T
Q
V
N
D
S
I
S
Site 81
S789
T
Q
V
N
D
S
I
S
A
E
T
A
E
Q
M
Site 82
S804
D
V
D
Q
Q
E
H
S
A
E
E
G
S
V
C
Site 83
S809
E
H
S
A
E
E
G
S
V
C
D
P
P
P
A
Site 84
T817
V
C
D
P
P
P
A
T
K
A
D
S
V
D
V
Site 85
S821
P
P
A
T
K
A
D
S
V
D
V
E
V
R
V
Site 86
S834
R
V
P
E
N
H
A
S
K
V
E
G
D
N
T
Site 87
T841
S
K
V
E
G
D
N
T
K
E
R
D
L
D
R
Site 88
S850
E
R
D
L
D
R
A
S
E
K
V
E
P
R
D
Site 89
S875
A
Q
R
P
E
P
Q
S
D
N
D
S
S
A
T
Site 90
S879
E
P
Q
S
D
N
D
S
S
A
T
C
S
A
D
Site 91
S880
P
Q
S
D
N
D
S
S
A
T
C
S
A
D
E
Site 92
S884
N
D
S
S
A
T
C
S
A
D
E
D
V
D
G
Site 93
S903
Q
R
M
F
P
M
D
S
K
P
S
L
L
N
P
Site 94
S906
F
P
M
D
S
K
P
S
L
L
N
P
T
G
S
Site 95
S917
P
T
G
S
I
L
V
S
S
P
L
K
P
N
P
Site 96
Y957
I
G
T
P
V
S
G
Y
A
L
Y
Q
R
H
I
Site 97
Y960
P
V
S
G
Y
A
L
Y
Q
R
H
I
K
A
M
Site 98
S989
Q
I
D
L
E
C
R
S
S
T
S
P
C
G
T
Site 99
S990
I
D
L
E
C
R
S
S
T
S
P
C
G
T
S
Site 100
T991
D
L
E
C
R
S
S
T
S
P
C
G
T
S
K
Site 101
S992
L
E
C
R
S
S
T
S
P
C
G
T
S
K
S
Site 102
T996
S
S
T
S
P
C
G
T
S
K
S
P
N
R
E
Site 103
S997
S
T
S
P
C
G
T
S
K
S
P
N
R
E
W
Site 104
S999
S
P
C
G
T
S
K
S
P
N
R
E
W
E
V
Site 105
T1016
P
A
P
H
Q
V
I
T
N
L
P
E
G
V
R
Site 106
T1026
P
E
G
V
R
L
P
T
T
R
P
T
R
P
P
Site 107
T1027
E
G
V
R
L
P
T
T
R
P
T
R
P
P
P
Site 108
T1030
R
L
P
T
T
R
P
T
R
P
P
P
P
L
I
Site 109
S1039
P
P
P
P
L
I
P
S
S
K
T
T
V
A
S
Site 110
S1040
P
P
P
L
I
P
S
S
K
T
T
V
A
S
E
Site 111
T1043
L
I
P
S
S
K
T
T
V
A
S
E
K
P
S
Site 112
S1046
S
S
K
T
T
V
A
S
E
K
P
S
F
I
M
Site 113
S1056
P
S
F
I
M
G
G
S
I
S
Q
G
T
P
G
Site 114
T1061
G
G
S
I
S
Q
G
T
P
G
T
Y
L
T
S
Site 115
T1064
I
S
Q
G
T
P
G
T
Y
L
T
S
H
N
Q
Site 116
Y1065
S
Q
G
T
P
G
T
Y
L
T
S
H
N
Q
A
Site 117
T1067
G
T
P
G
T
Y
L
T
S
H
N
Q
A
S
Y
Site 118
T1078
Q
A
S
Y
T
Q
E
T
P
K
P
S
V
G
S
Site 119
S1082
T
Q
E
T
P
K
P
S
V
G
S
I
S
L
G
Site 120
S1085
T
P
K
P
S
V
G
S
I
S
L
G
L
P
R
Site 121
S1087
K
P
S
V
G
S
I
S
L
G
L
P
R
Q
Q
Site 122
S1099
R
Q
Q
E
S
A
K
S
A
T
L
P
Y
I
K
Site 123
S1111
Y
I
K
Q
E
E
F
S
P
R
S
Q
N
S
Q
Site 124
S1114
Q
E
E
F
S
P
R
S
Q
N
S
Q
P
E
G
Site 125
S1117
F
S
P
R
S
Q
N
S
Q
P
E
G
L
L
V
Site 126
T1135
H
E
G
V
V
R
G
T
A
G
A
I
Q
E
G
Site 127
S1143
A
G
A
I
Q
E
G
S
I
T
R
G
T
P
T
Site 128
T1145
A
I
Q
E
G
S
I
T
R
G
T
P
T
S
K
Site 129
T1148
E
G
S
I
T
R
G
T
P
T
S
K
I
S
V
Site 130
T1150
S
I
T
R
G
T
P
T
S
K
I
S
V
E
S
Site 131
S1151
I
T
R
G
T
P
T
S
K
I
S
V
E
S
I
Site 132
S1154
G
T
P
T
S
K
I
S
V
E
S
I
P
S
L
Site 133
S1157
T
S
K
I
S
V
E
S
I
P
S
L
R
G
S
Site 134
S1164
S
I
P
S
L
R
G
S
I
T
Q
G
T
P
A
Site 135
T1166
P
S
L
R
G
S
I
T
Q
G
T
P
A
L
P
Site 136
T1169
R
G
S
I
T
Q
G
T
P
A
L
P
Q
T
G
Site 137
S1195
S
R
M
P
I
E
D
S
S
P
E
K
G
R
E
Site 138
S1196
R
M
P
I
E
D
S
S
P
E
K
G
R
E
E
Site 139
S1206
K
G
R
E
E
A
A
S
K
G
H
V
I
Y
E
Site 140
Y1212
A
S
K
G
H
V
I
Y
E
G
K
S
G
H
I
Site 141
S1221
G
K
S
G
H
I
L
S
Y
D
N
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S
T
F
Q
N
S
P
S
Site 294
T2080
P
Q
Q
P
P
T
S
T
F
Q
N
S
P
S
A
Site 295
S2084
P
T
S
T
F
Q
N
S
P
S
A
L
V
S
T
Site 296
S2086
S
T
F
Q
N
S
P
S
A
L
V
S
T
P
V
Site 297
S2090
N
S
P
S
A
L
V
S
T
P
V
R
T
K
T
Site 298
T2091
S
P
S
A
L
V
S
T
P
V
R
T
K
T
S
Site 299
T2097
S
T
P
V
R
T
K
T
S
N
R
Y
S
P
E
Site 300
S2098
T
P
V
R
T
K
T
S
N
R
Y
S
P
E
S
Site 301
Y2101
R
T
K
T
S
N
R
Y
S
P
E
S
Q
A
Q
Site 302
S2102
T
K
T
S
N
R
Y
S
P
E
S
Q
A
Q
S
Site 303
S2105
S
N
R
Y
S
P
E
S
Q
A
Q
S
V
H
H
Site 304
S2109
S
P
E
S
Q
A
Q
S
V
H
H
Q
R
P
G
Site 305
S2117
V
H
H
Q
R
P
G
S
R
V
S
P
E
N
L
Site 306
S2120
Q
R
P
G
S
R
V
S
P
E
N
L
V
D
K
Site 307
S2128
P
E
N
L
V
D
K
S
R
G
S
R
P
G
K
Site 308
S2131
L
V
D
K
S
R
G
S
R
P
G
K
S
P
E
Site 309
S2136
R
G
S
R
P
G
K
S
P
E
R
S
H
V
S
Site 310
S2140
P
G
K
S
P
E
R
S
H
V
S
S
E
P
Y
Site 311
S2144
P
E
R
S
H
V
S
S
E
P
Y
E
P
I
S
Site 312
Y2147
S
H
V
S
S
E
P
Y
E
P
I
S
P
P
Q
Site 313
S2151
S
E
P
Y
E
P
I
S
P
P
Q
V
P
V
V
Site 314
S2164
V
V
H
E
K
Q
D
S
L
L
L
L
S
Q
R
Site 315
S2169
Q
D
S
L
L
L
L
S
Q
R
G
A
E
P
A
Site 316
S2184
E
Q
R
N
D
A
R
S
P
G
S
I
S
Y
L
Site 317
S2187
N
D
A
R
S
P
G
S
I
S
Y
L
P
S
F
Site 318
S2189
A
R
S
P
G
S
I
S
Y
L
P
S
F
F
T
Site 319
Y2190
R
S
P
G
S
I
S
Y
L
P
S
F
F
T
K
Site 320
S2193
G
S
I
S
Y
L
P
S
F
F
T
K
L
E
N
Site 321
S2202
F
T
K
L
E
N
T
S
P
M
V
K
S
K
K
Site 322
S2207
N
T
S
P
M
V
K
S
K
K
Q
E
I
F
R
Site 323
S2218
E
I
F
R
K
L
N
S
S
G
G
G
D
S
D
Site 324
S2219
I
F
R
K
L
N
S
S
G
G
G
D
S
D
M
Site 325
S2224
N
S
S
G
G
G
D
S
D
M
A
A
A
Q
P
Site 326
S2244
N
L
P
A
V
T
T
S
G
S
V
S
S
R
G
Site 327
S2246
P
A
V
T
T
S
G
S
V
S
S
R
G
H
S
Site 328
S2248
V
T
T
S
G
S
V
S
S
R
G
H
S
F
A
Site 329
S2249
T
T
S
G
S
V
S
S
R
G
H
S
F
A
D
Site 330
S2253
S
V
S
S
R
G
H
S
F
A
D
P
A
S
N
Site 331
S2259
H
S
F
A
D
P
A
S
N
L
G
L
E
D
I
Site 332
S2274
I
R
K
A
L
M
G
S
F
D
D
K
V
E
D
Site 333
S2300
V
P
G
T
A
N
T
S
V
V
T
S
G
E
T
Site 334
S2304
A
N
T
S
V
V
T
S
G
E
T
R
R
E
E
Site 335
S2315
R
R
E
E
G
D
P
S
P
H
S
G
G
V
C
Site 336
S2318
E
G
D
P
S
P
H
S
G
G
V
C
K
P
K
Site 337
S2328
V
C
K
P
K
L
I
S
K
S
N
S
R
K
S
Site 338
S2330
K
P
K
L
I
S
K
S
N
S
R
K
S
K
S
Site 339
S2332
K
L
I
S
K
S
N
S
R
K
S
K
S
P
I
Site 340
S2335
S
K
S
N
S
R
K
S
K
S
P
I
P
G
Q
Site 341
S2337
S
N
S
R
K
S
K
S
P
I
P
G
Q
G
Y
Site 342
Y2344
S
P
I
P
G
Q
G
Y
L
G
T
E
R
P
S
Site 343
T2347
P
G
Q
G
Y
L
G
T
E
R
P
S
S
V
S
Site 344
S2351
Y
L
G
T
E
R
P
S
S
V
S
S
V
H
S
Site 345
S2352
L
G
T
E
R
P
S
S
V
S
S
V
H
S
E
Site 346
S2354
T
E
R
P
S
S
V
S
S
V
H
S
E
G
D
Site 347
S2355
E
R
P
S
S
V
S
S
V
H
S
E
G
D
Y
Site 348
S2358
S
S
V
S
S
V
H
S
E
G
D
Y
H
R
Q
Site 349
Y2362
S
V
H
S
E
G
D
Y
H
R
Q
T
P
G
W
Site 350
S2376
W
A
W
E
D
R
P
S
S
T
G
S
T
Q
F
Site 351
S2377
A
W
E
D
R
P
S
S
T
G
S
T
Q
F
P
Site 352
S2380
D
R
P
S
S
T
G
S
T
Q
F
P
Y
N
P
Site 353
T2381
R
P
S
S
T
G
S
T
Q
F
P
Y
N
P
L
Site 354
Y2385
T
G
S
T
Q
F
P
Y
N
P
L
T
M
R
M
Site 355
T2389
Q
F
P
Y
N
P
L
T
M
R
M
L
S
S
T
Site 356
S2394
P
L
T
M
R
M
L
S
S
T
P
P
T
P
I
Site 357
S2395
L
T
M
R
M
L
S
S
T
P
P
T
P
I
A
Site 358
T2396
T
M
R
M
L
S
S
T
P
P
T
P
I
A
C
Site 359
T2399
M
L
S
S
T
P
P
T
P
I
A
C
A
P
S
Site 360
S2429
R
E
P
A
P
L
L
S
A
Q
Y
E
T
L
S
Site 361
Y2432
A
P
L
L
S
A
Q
Y
E
T
L
S
D
S
D
Site 362
T2434
L
L
S
A
Q
Y
E
T
L
S
D
S
D
D
_
Site 363
S2436
S
A
Q
Y
E
T
L
S
D
S
D
D
_
_
_
Site 364
S2438
Q
Y
E
T
L
S
D
S
D
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation