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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM3
Full Name:
Tripartite motif-containing protein 3
Alias:
BERP; Brain expressed ring finger; Brain-expressed RING finger protein; HAC1; RING finger protein 22; RING finger protein 97; RNF22; RNF97; Tripartite motif protein TRIM3; Tripartite motif-containing 3
Type:
Cytoskeletal protein
Mass (Da):
80830
Number AA:
744
UniProt ID:
O75382
International Prot ID:
IPI00152001
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
K
R
E
D
S
P
G
P
E
V
Q
P
Site 2
S23
D
K
Q
F
L
V
C
S
I
C
L
D
R
Y
Q
Site 3
Y49
C
E
R
C
L
Q
N
Y
I
P
A
Q
S
L
T
Site 4
S58
P
A
Q
S
L
T
L
S
C
P
V
C
R
Q
T
Site 5
T65
S
C
P
V
C
R
Q
T
S
I
L
P
E
Q
G
Site 6
S106
P
E
D
P
H
P
L
S
V
V
A
G
R
P
L
Site 7
S114
V
V
A
G
R
P
L
S
C
P
N
H
E
G
K
Site 8
Y126
E
G
K
T
M
E
F
Y
C
E
A
C
E
T
A
Site 9
S187
I
A
L
V
G
G
I
S
Q
Q
L
Q
E
R
K
Site 10
S202
A
E
A
L
A
Q
I
S
A
A
F
E
D
L
E
Site 11
S221
Q
R
K
Q
A
L
V
S
D
L
E
T
I
C
G
Site 12
S236
A
K
Q
K
V
L
Q
S
Q
L
D
T
L
R
Q
Site 13
T240
V
L
Q
S
Q
L
D
T
L
R
Q
G
Q
E
H
Site 14
S250
Q
G
Q
E
H
I
G
S
S
C
S
F
A
E
Q
Site 15
S253
E
H
I
G
S
S
C
S
F
A
E
Q
A
L
R
Site 16
T325
T
S
A
T
A
H
E
T
V
A
T
G
E
G
L
Site 17
T344
V
G
Q
P
A
S
L
T
V
T
T
K
D
K
D
Site 18
T346
Q
P
A
S
L
T
V
T
T
K
D
K
D
G
R
Site 19
S359
G
R
L
V
R
T
G
S
A
E
L
R
A
E
I
Site 20
Y386
V
D
H
K
N
G
T
Y
E
L
V
Y
T
A
R
Site 21
Y390
N
G
T
Y
E
L
V
Y
T
A
R
T
E
G
E
Site 22
T391
G
T
Y
E
L
V
Y
T
A
R
T
E
G
E
L
Site 23
S412
Y
G
Q
P
V
R
G
S
P
F
R
V
R
A
L
Site 24
S427
R
P
G
D
L
P
P
S
P
D
D
V
K
R
R
Site 25
S437
D
V
K
R
R
V
K
S
P
G
G
P
G
S
H
Site 26
S443
K
S
P
G
G
P
G
S
H
V
R
Q
K
A
V
Site 27
S454
Q
K
A
V
R
R
P
S
S
M
Y
S
T
G
G
Site 28
S455
K
A
V
R
R
P
S
S
M
Y
S
T
G
G
K
Site 29
Y457
V
R
R
P
S
S
M
Y
S
T
G
G
K
R
K
Site 30
S458
R
R
P
S
S
M
Y
S
T
G
G
K
R
K
D
Site 31
T459
R
P
S
S
M
Y
S
T
G
G
K
R
K
D
N
Site 32
S478
E
L
V
F
R
V
G
S
R
G
R
E
K
G
E
Site 33
S529
R
F
G
V
R
G
R
S
P
G
Q
L
Q
R
P
Site 34
T537
P
G
Q
L
Q
R
P
T
G
V
A
V
D
T
N
Site 35
S558
D
Y
D
N
R
W
V
S
I
F
S
P
E
G
K
Site 36
S561
N
R
W
V
S
I
F
S
P
E
G
K
F
K
T
Site 37
T568
S
P
E
G
K
F
K
T
K
I
G
A
G
R
L
Site 38
T618
R
F
G
G
R
G
A
T
D
R
H
F
A
G
P
Site 39
T639
N
K
N
E
I
V
V
T
D
F
H
N
H
S
V
Site 40
Y649
H
N
H
S
V
K
V
Y
S
A
D
G
E
F
L
Site 41
S661
E
F
L
F
K
F
G
S
H
G
E
G
N
G
Q
Site 42
S698
S
R
I
Q
V
F
D
S
S
G
S
F
L
S
Y
Site 43
S701
Q
V
F
D
S
S
G
S
F
L
S
Y
I
N
T
Site 44
S704
D
S
S
G
S
F
L
S
Y
I
N
T
S
A
E
Site 45
Y705
S
S
G
S
F
L
S
Y
I
N
T
S
A
E
P
Site 46
T708
S
F
L
S
Y
I
N
T
S
A
E
P
L
Y
G
Site 47
Y714
N
T
S
A
E
P
L
Y
G
P
Q
G
L
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation