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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CS
Full Name:
Citrate synthase, mitochondrial
Alias:
CISY; EC 2.3.3.1
Type:
Enzyme, Transferase, Mitochondrial
Mass (Da):
51712
Number AA:
466
UniProt ID:
O75390
International Prot ID:
IPI00025366
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004108
PhosphoSite+
KinaseNET
Biological Process:
GO:0044262
GO:0006099
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
L
L
T
A
A
A
R
L
L
G
Site 2
T13
A
A
A
R
L
L
G
T
K
N
A
S
C
L
V
Site 3
S27
V
L
A
A
R
H
A
S
A
S
S
T
N
L
K
Site 4
S29
A
A
R
H
A
S
A
S
S
T
N
L
K
D
I
Site 5
T31
R
H
A
S
A
S
S
T
N
L
K
D
I
L
A
Site 6
T50
K
E
Q
A
R
I
K
T
F
R
Q
Q
H
G
K
Site 7
T58
F
R
Q
Q
H
G
K
T
V
V
G
Q
I
T
V
Site 8
Y69
Q
I
T
V
D
M
M
Y
G
G
M
R
G
M
K
Site 9
Y80
R
G
M
K
G
L
V
Y
E
T
S
V
L
D
P
Site 10
S83
K
G
L
V
Y
E
T
S
V
L
D
P
D
E
G
Site 11
S97
G
I
R
F
R
G
F
S
I
P
E
C
Q
K
L
Site 12
S135
I
P
T
E
E
Q
V
S
W
L
S
K
E
W
A
Site 13
S166
P
T
N
L
H
P
M
S
Q
L
S
A
A
V
T
Site 14
T173
S
Q
L
S
A
A
V
T
A
L
N
S
E
S
N
Site 15
Y185
E
S
N
F
A
R
A
Y
A
Q
G
I
S
R
T
Site 16
Y194
Q
G
I
S
R
T
K
Y
W
E
L
I
Y
E
D
Site 17
Y199
T
K
Y
W
E
L
I
Y
E
D
S
M
D
L
I
Site 18
Y221
A
K
I
Y
R
N
L
Y
R
E
G
S
G
I
G
Site 19
S225
R
N
L
Y
R
E
G
S
G
I
G
A
I
D
S
Site 20
S232
S
G
I
G
A
I
D
S
N
L
D
W
S
H
N
Site 21
Y258
F
T
E
L
T
R
L
Y
L
T
I
H
S
D
H
Site 22
S263
R
L
Y
L
T
I
H
S
D
H
E
G
G
N
V
Site 23
S271
D
H
E
G
G
N
V
S
A
H
T
S
H
L
V
Site 24
S324
K
E
V
G
K
D
V
S
D
E
K
L
R
D
Y
Site 25
Y331
S
D
E
K
L
R
D
Y
I
W
N
T
L
N
S
Site 26
T335
L
R
D
Y
I
W
N
T
L
N
S
G
R
V
V
Site 27
S338
Y
I
W
N
T
L
N
S
G
R
V
V
P
G
Y
Site 28
Y345
S
G
R
V
V
P
G
Y
G
H
A
V
L
R
K
Site 29
T353
G
H
A
V
L
R
K
T
D
P
R
Y
T
C
Q
Site 30
Y357
L
R
K
T
D
P
R
Y
T
C
Q
R
E
F
A
Site 31
T358
R
K
T
D
P
R
Y
T
C
Q
R
E
F
A
L
Site 32
Y381
F
K
L
V
A
Q
L
Y
K
I
V
P
N
V
L
Site 33
Y411
H
S
G
V
L
L
Q
Y
Y
G
M
T
E
M
N
Site 34
Y412
S
G
V
L
L
Q
Y
Y
G
M
T
E
M
N
Y
Site 35
S439
V
L
A
Q
L
I
W
S
R
A
L
G
F
P
L
Site 36
S451
F
P
L
E
R
P
K
S
M
S
T
E
G
L
M
Site 37
S453
L
E
R
P
K
S
M
S
T
E
G
L
M
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation