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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC45L
Full Name:
Cell division control protein 45 homolog
Alias:
CC45L; Cdc45; CDC45 cell division cycle 45-like; CDC45L2; CDC45-like; Cell division cycle 45-like 2; PORC-PI-1
Type:
Cell cycle regulation
Mass (Da):
65569
Number AA:
566
UniProt ID:
O75419
International Prot ID:
IPI00025695
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000076
GO:0006270
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
S
D
F
R
K
E
F
Y
E
V
V
Q
S
Q
R
Site 2
S25
R
V
L
L
F
V
A
S
D
V
D
A
L
C
A
Site 3
S53
Q
Y
T
L
V
P
V
S
G
W
Q
E
L
E
T
Site 4
Y71
E
H
K
E
Q
F
H
Y
F
I
L
I
N
C
G
Site 5
Y130
D
D
L
E
V
P
A
Y
E
D
I
F
R
D
E
Site 6
S144
E
E
E
D
E
E
H
S
G
N
D
S
D
G
S
Site 7
S148
E
E
H
S
G
N
D
S
D
G
S
E
P
S
E
Site 8
S151
S
G
N
D
S
D
G
S
E
P
S
E
K
R
T
Site 9
S154
D
S
D
G
S
E
P
S
E
K
R
T
R
L
E
Site 10
T158
S
E
P
S
E
K
R
T
R
L
E
E
E
I
V
Site 11
T168
E
E
E
I
V
E
Q
T
M
R
R
R
Q
R
R
Site 12
Y188
R
R
D
I
L
F
D
Y
E
Q
Y
E
Y
H
G
Site 13
Y191
I
L
F
D
Y
E
Q
Y
E
Y
H
G
T
S
S
Site 14
Y193
F
D
Y
E
Q
Y
E
Y
H
G
T
S
S
A
M
Site 15
S250
G
V
L
Q
R
H
V
S
R
H
N
H
R
N
E
Site 16
T262
R
N
E
D
E
E
N
T
L
S
V
D
C
T
R
Site 17
S264
E
D
E
E
N
T
L
S
V
D
C
T
R
I
S
Site 18
T268
N
T
L
S
V
D
C
T
R
I
S
F
E
Y
D
Site 19
S271
S
V
D
C
T
R
I
S
F
E
Y
D
L
R
L
Site 20
Y281
Y
D
L
R
L
V
L
Y
Q
H
W
S
L
H
D
Site 21
T293
L
H
D
S
L
C
N
T
S
Y
T
A
A
R
F
Site 22
Y295
D
S
L
C
N
T
S
Y
T
A
A
R
F
K
L
Site 23
S304
A
A
R
F
K
L
W
S
V
H
G
Q
K
R
L
Site 24
S335
K
F
Q
A
M
D
I
S
L
K
E
N
L
R
E
Site 25
S347
L
R
E
M
I
E
E
S
A
N
K
F
G
M
K
Site 26
T360
M
K
D
M
R
V
Q
T
F
S
I
H
F
G
F
Site 27
S386
A
T
M
S
L
M
E
S
P
E
K
D
G
S
G
Site 28
S392
E
S
P
E
K
D
G
S
G
T
D
H
F
I
Q
Site 29
S403
H
F
I
Q
A
L
D
S
L
S
R
S
N
L
D
Site 30
S405
I
Q
A
L
D
S
L
S
R
S
N
L
D
K
L
Site 31
S407
A
L
D
S
L
S
R
S
N
L
D
K
L
Y
H
Site 32
Y413
R
S
N
L
D
K
L
Y
H
G
L
E
L
A
K
Site 33
T426
A
K
K
Q
L
R
A
T
Q
Q
T
I
A
S
C
Site 34
S449
Q
G
P
F
L
Y
C
S
L
M
E
G
T
P
D
Site 35
S476
L
S
K
H
L
L
K
S
F
V
C
S
T
K
N
Site 36
S480
L
L
K
S
F
V
C
S
T
K
N
R
R
C
K
Site 37
T513
V
V
G
I
P
P
E
T
D
S
S
D
R
K
N
Site 38
S515
G
I
P
P
E
T
D
S
S
D
R
K
N
F
F
Site 39
S516
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Site 40
S532
A
F
E
K
A
A
E
S
T
S
S
R
M
L
H
Site 41
S534
E
K
A
A
E
S
T
S
S
R
M
L
H
N
H
Site 42
S535
K
A
A
E
S
T
S
S
R
M
L
H
N
H
F
Site 43
S545
L
H
N
H
F
D
L
S
V
I
E
L
K
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation