PhosphoNET

           
Protein Info 
   
Short Name:  LRCH4
Full Name:  Leucine-rich repeat and calponin homology domain-containing protein 4
Alias:  leucine-rich neuronal protein; leucine-rich repeats and calponin homology domain-containing 4; leucine-rich repeats and calponiny (CH) domain containing 4; LRN; LRRN1; LRRN4; PP14183; SAP25
Type:  Transcription, coactivator/corepressor
Mass (Da):  73450
Number AA:  683
UniProt ID:  O75427
International Prot ID:  IPI00000173
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016605     Uniprot OncoNet
Molecular Function:  GO:0005515     PhosphoSite+ KinaseNET
Biological Process:  GO:0007399     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T19GGEEAAATTSVPGSP
Site 2T20GEEAAATTSVPGSPG
Site 3S21EEAAATTSVPGSPGL
Site 4S25ATTSVPGSPGLPGRR
Site 5S33PGLPGRRSAERALEE
Site 6T46EEAVATGTLNLSNRR
Site 7S50ATGTLNLSNRRLKHF
Site 8S64FPRGAARSYDLSDIT
Site 9Y65PRGAARSYDLSDITQ
Site 10S68AARSYDLSDITQADL
Site 11T71SYDLSDITQADLSRN
Site 12S76DITQADLSRNRFPEV
Site 13Y99SLEGLSLYHNCLRCL
Site 14Y118GNLTALTYLNLSRNQ
Site 15S127NLSRNQLSLLPPYIC
Site 16S160PDIGTLGSLRQLDVS
Site 17S167SLRQLDVSSNELQSL
Site 18S168LRQLDVSSNELQSLP
Site 19S173VSSNELQSLPSELCG
Site 20S176NELQSLPSELCGLSS
Site 21S182PSELCGLSSLRDLNV
Site 22S183SELCGLSSLRDLNVR
Site 23S195NVRRNQLSTLPEELG
Site 24T196VRRNQLSTLPEELGD
Site 25S212PLVRLDFSCNRVSRI
Site 26S222RVSRIPVSFCRLRHL
Site 27S241LDSNPLQSPPAQVCL
Site 28Y257GKLHIFKYLSTEAGQ
Site 29S259LHIFKYLSTEAGQRG
Site 30S267TEAGQRGSALGDLAP
Site 31S275ALGDLAPSRPPSFSP
Site 32S279LAPSRPPSFSPCPAE
Site 33S281PSRPPSFSPCPAEDL
Site 34Y294DLFPGHRYDGGLDSG
Site 35S300RYDGGLDSGFHSVDS
Site 36S304GLDSGFHSVDSGSKR
Site 37S307SGFHSVDSGSKRWSG
Site 38S309FHSVDSGSKRWSGNE
Site 39S313DSGSKRWSGNESTDE
Site 40S317KRWSGNESTDEFSEL
Site 41T318RWSGNESTDEFSELS
Site 42S322NESTDEFSELSFRIS
Site 43S325TDEFSELSFRISELA
Site 44S329SELSFRISELAREPR
Site 45S346RERKEDGSADGDPVQ
Site 46S359VQIDFIDSHVPGEDE
Site 47T370GEDEERGTVEEQRPP
Site 48S380EQRPPELSPGAGDRE
Site 49S391GDRERAPSSRREEPA
Site 50S392DRERAPSSRREEPAG
Site 51T407EERRRPDTLQLWQER
Site 52S422ERRQQQQSGAWGAPR
Site 53S432WGAPRKDSLLKPGLR
Site 54S457TQAMHNGSPKSSASQ
Site 55S460MHNGSPKSSASQAGA
Site 56S461HNGSPKSSASQAGAA
Site 57S463GSPKSSASQAGAAAG
Site 58S500PAPRPLGSIQRPNSF
Site 59S506GSIQRPNSFLFRSSS
Site 60S511PNSFLFRSSSQSGSG
Site 61S512NSFLFRSSSQSGSGP
Site 62S513SFLFRSSSQSGSGPS
Site 63S515LFRSSSQSGSGPSSP
Site 64S517RSSSQSGSGPSSPDS
Site 65S520SQSGSGPSSPDSVLR
Site 66S521QSGSGPSSPDSVLRP
Site 67S524SGPSSPDSVLRPRRY
Site 68Y531SVLRPRRYPQVPDEK
Site 69T542PDEKDLMTQLRQVLE
Site 70S550QLRQVLESRLQRPLP
Site 71S581ANQLRPRSVPFIHVP
Site 72S606KARKNVESFLEACRK
Site 73S623VPEADLCSPSDLLQG
Site 74S625EADLCSPSDLLQGTA
Site 75T631PSDLLQGTARGLRTA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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