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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF254
Full Name:
Zinc finger protein 254
Alias:
Bone marrow zinc finger 5;Hematopoietic cell-derived zinc finger protein 1;Zinc finger protein 539;Zinc finger protein 91-like
Type:
Mass (Da):
77160
Number AA:
659
UniProt ID:
O75437
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
G
P
P
R
S
L
E
M
G
L
L
T
Site 2
S23
R
D
V
A
I
E
F
S
L
E
E
W
Q
H
L
Site 3
Y38
D
I
A
Q
Q
N
L
Y
R
N
V
M
L
E
N
Site 4
S103
P
E
Q
G
M
E
D
S
F
Q
K
A
I
L
R
Site 5
Y112
Q
K
A
I
L
R
R
Y
G
K
Y
G
H
E
N
Site 6
Y115
I
L
R
R
Y
G
K
Y
G
H
E
N
L
Q
L
Site 7
S128
Q
L
R
K
G
C
K
S
V
D
E
Y
K
V
N
Site 8
Y132
G
C
K
S
V
D
E
Y
K
V
N
K
E
G
Y
Site 9
Y159
K
V
F
Q
C
D
K
Y
L
K
V
F
Y
K
F
Site 10
T177
N
R
P
K
I
R
H
T
E
K
K
S
F
K
C
Site 11
S181
I
R
H
T
E
K
K
S
F
K
C
K
K
R
V
Site 12
S202
S
H
K
T
Q
H
K
S
I
Y
H
R
E
K
S
Site 13
Y204
K
T
Q
H
K
S
I
Y
H
R
E
K
S
Y
K
Site 14
Y210
I
Y
H
R
E
K
S
Y
K
C
K
E
C
G
K
Site 15
S223
G
K
T
F
N
W
S
S
T
L
T
N
H
R
K
Site 16
Y232
L
T
N
H
R
K
I
Y
T
E
E
K
P
Y
K
Site 17
T233
T
N
H
R
K
I
Y
T
E
E
K
P
Y
K
C
Site 18
Y238
I
Y
T
E
E
K
P
Y
K
C
E
E
Y
N
K
Site 19
Y243
K
P
Y
K
C
E
E
Y
N
K
S
P
K
Q
L
Site 20
S246
K
C
E
E
Y
N
K
S
P
K
Q
L
S
T
L
Site 21
T252
K
S
P
K
Q
L
S
T
L
T
T
H
E
I
I
Site 22
T255
K
Q
L
S
T
L
T
T
H
E
I
I
H
A
G
Site 23
Y266
I
H
A
G
E
K
L
Y
K
C
E
E
C
G
E
Site 24
S279
G
E
A
F
N
R
S
S
N
L
T
T
H
K
I
Site 25
T282
F
N
R
S
S
N
L
T
T
H
K
I
I
H
T
Site 26
S307
G
K
A
F
I
W
S
S
T
L
T
E
H
K
K
Site 27
T310
F
I
W
S
S
T
L
T
E
H
K
K
I
H
T
Site 28
S335
G
K
A
F
I
W
S
S
T
L
T
R
H
K
R
Site 29
T336
K
A
F
I
W
S
S
T
L
T
R
H
K
R
M
Site 30
T345
T
R
H
K
R
M
H
T
G
E
K
P
Y
K
C
Site 31
S360
E
E
C
G
K
A
F
S
Q
S
S
T
L
T
T
Site 32
S362
C
G
K
A
F
S
Q
S
S
T
L
T
T
H
K
Site 33
S363
G
K
A
F
S
Q
S
S
T
L
T
T
H
K
I
Site 34
T364
K
A
F
S
Q
S
S
T
L
T
T
H
K
I
I
Site 35
T366
F
S
Q
S
S
T
L
T
T
H
K
I
I
H
T
Site 36
T367
S
Q
S
S
T
L
T
T
H
K
I
I
H
T
G
Site 37
S391
G
K
A
F
K
Q
L
S
T
L
T
T
H
K
I
Site 38
T395
K
Q
L
S
T
L
T
T
H
K
I
I
H
V
G
Site 39
Y406
I
H
V
G
E
K
L
Y
K
C
E
E
C
G
K
Site 40
S418
C
G
K
G
F
N
R
S
S
N
L
T
T
H
K
Site 41
S419
G
K
G
F
N
R
S
S
N
L
T
T
H
K
I
Site 42
S447
G
K
A
F
I
W
S
S
T
L
T
K
H
K
R
Site 43
T450
F
I
W
S
S
T
L
T
K
H
K
R
I
H
T
Site 44
T457
T
K
H
K
R
I
H
T
R
E
K
P
Y
K
C
Site 45
S498
K
C
E
E
C
G
K
S
F
S
Q
S
S
T
L
Site 46
S500
E
E
C
G
K
S
F
S
Q
S
S
T
L
T
T
Site 47
S502
C
G
K
S
F
S
Q
S
S
T
L
T
T
H
K
Site 48
S503
G
K
S
F
S
Q
S
S
T
L
T
T
H
K
I
Site 49
T504
K
S
F
S
Q
S
S
T
L
T
T
H
K
I
I
Site 50
S531
G
K
A
F
N
W
S
S
T
L
T
K
H
K
I
Site 51
T532
K
A
F
N
W
S
S
T
L
T
K
H
K
I
I
Site 52
Y546
I
H
T
E
E
K
P
Y
K
C
E
K
C
G
K
Site 53
S558
C
G
K
A
F
K
Q
S
S
I
L
T
N
H
K
Site 54
S559
G
K
A
F
K
Q
S
S
I
L
T
N
H
K
R
Site 55
T562
F
K
Q
S
S
I
L
T
N
H
K
R
I
H
T
Site 56
T569
T
N
H
K
R
I
H
T
G
E
K
P
Y
K
C
Site 57
S582
K
C
E
E
C
G
K
S
F
N
R
S
S
T
F
Site 58
S586
C
G
K
S
F
N
R
S
S
T
F
T
K
H
K
Site 59
S587
G
K
S
F
N
R
S
S
T
F
T
K
H
K
V
Site 60
T588
K
S
F
N
R
S
S
T
F
T
K
H
K
V
I
Site 61
T590
F
N
R
S
S
T
F
T
K
H
K
V
I
H
T
Site 62
S615
G
K
A
F
F
W
S
S
T
L
T
K
H
K
R
Site 63
T616
K
A
F
F
W
S
S
T
L
T
K
H
K
R
I
Site 64
T625
T
K
H
K
R
I
H
T
G
E
Q
P
Y
K
W
Site 65
S642
F
G
K
A
F
N
R
S
S
H
L
T
T
D
K
Site 66
S643
G
K
A
F
N
R
S
S
H
L
T
T
D
K
I
Site 67
T646
F
N
R
S
S
H
L
T
T
D
K
I
T
H
W
Site 68
T647
N
R
S
S
H
L
T
T
D
K
I
T
H
W
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation