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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PMPCB
Full Name:
Mitochondrial-processing peptidase subunit beta
Alias:
beta-MPP; mitochondrial processing peptidase beta subunit, mitochondrial precursor; mitochondrial processing peptidase-beta; MPP11; MPPB; MPPP52; P-52; peptidase (mitochondrial processing) beta
Type:
EC 3.4.24.64; Protease
Mass (Da):
54366
Number AA:
489
UniProt ID:
O75439
International Prot ID:
IPI00289535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
R
R
L
W
G
F
S
E
S
L
L
I
R
G
Site 2
Y36
G
A
A
G
R
S
L
Y
F
G
E
N
R
L
R
Site 3
S44
F
G
E
N
R
L
R
S
T
Q
A
A
T
Q
V
Site 4
T45
G
E
N
R
L
R
S
T
Q
A
A
T
Q
V
V
Site 5
T61
N
V
P
E
T
R
V
T
C
L
E
S
G
L
R
Site 6
S71
E
S
G
L
R
V
A
S
E
D
S
G
L
S
T
Site 7
S89
G
L
W
I
D
A
G
S
R
Y
E
N
E
K
N
Site 8
T111
E
H
M
A
F
K
G
T
K
K
R
S
Q
L
D
Site 9
Y133
M
G
A
H
L
N
A
Y
T
S
R
E
Q
T
V
Site 10
T139
A
Y
T
S
R
E
Q
T
V
Y
Y
A
K
A
F
Site 11
Y141
T
S
R
E
Q
T
V
Y
Y
A
K
A
F
S
K
Site 12
Y142
S
R
E
Q
T
V
Y
Y
A
K
A
F
S
K
D
Site 13
Y202
D
Y
L
H
A
T
A
Y
Q
N
T
A
L
G
R
Site 14
S220
G
P
T
E
N
I
K
S
I
S
R
K
D
L
V
Site 15
Y229
S
R
K
D
L
V
D
Y
I
T
T
H
Y
K
G
Site 16
T231
K
D
L
V
D
Y
I
T
T
H
Y
K
G
P
R
Site 17
Y234
V
D
Y
I
T
T
H
Y
K
G
P
R
I
V
L
Site 18
S263
A
K
F
H
F
G
D
S
L
C
T
H
K
G
E
Site 19
S282
P
P
C
K
F
T
G
S
E
I
R
V
R
D
D
Site 20
T341
S
S
K
L
A
Q
L
T
C
H
G
N
L
C
H
Site 21
S356
S
F
Q
S
F
N
T
S
Y
T
D
T
G
L
W
Site 22
Y357
F
Q
S
F
N
T
S
Y
T
D
T
G
L
W
G
Site 23
T390
K
E
W
M
R
L
C
T
S
V
T
E
S
E
V
Site 24
S391
E
W
M
R
L
C
T
S
V
T
E
S
E
V
A
Site 25
S395
L
C
T
S
V
T
E
S
E
V
A
R
A
R
N
Site 26
T406
R
A
R
N
L
L
K
T
N
M
L
L
Q
L
D
Site 27
Y429
I
G
R
Q
M
L
C
Y
N
R
R
I
P
I
P
Site 28
Y457
I
R
E
V
C
T
K
Y
I
Y
N
R
S
P
A
Site 29
Y459
E
V
C
T
K
Y
I
Y
N
R
S
P
A
I
A
Site 30
S462
T
K
Y
I
Y
N
R
S
P
A
I
A
A
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation