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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USH2A
Full Name:
Usherin
Alias:
RP39; US2; USH2; Usher syndrome 2A (autosomal recessive, mild); usherin
Type:
Adhesion
Mass (Da):
575600
Number AA:
5202
UniProt ID:
O75445
International Prot ID:
IPI00410150
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0042995
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005518
PhosphoSite+
KinaseNET
Biological Process:
GO:0048496
GO:0045494
GO:0050896
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S147
P
S
P
K
L
M
A
S
F
T
L
A
V
W
L
Site 2
Y463
I
L
T
P
G
P
N
Y
R
P
G
Y
N
N
F
Site 3
Y467
G
P
N
Y
R
P
G
Y
N
N
F
Y
N
T
P
Site 4
Y471
R
P
G
Y
N
N
F
Y
N
T
P
S
L
Q
E
Site 5
Y534
C
D
T
T
S
Q
P
Y
R
C
L
C
S
Q
E
Site 6
S583
Q
C
N
S
H
S
K
S
C
H
Y
N
I
S
V
Site 7
Y586
S
H
S
K
S
C
H
Y
N
I
S
V
D
P
F
Site 8
S589
K
S
C
H
Y
N
I
S
V
D
P
F
P
F
E
Site 9
S1256
P
K
M
Q
K
I
S
S
T
E
L
H
V
E
W
Site 10
S1424
Q
L
L
H
T
A
K
S
Q
E
L
S
Y
T
V
Site 11
Y1909
G
N
D
S
I
L
V
Y
Q
G
K
E
Q
S
V
Site 12
Y1917
Q
G
K
E
Q
S
V
Y
E
G
G
L
Q
P
F
Site 13
Y1927
G
L
Q
P
F
T
E
Y
L
Y
R
V
I
A
S
Site 14
T1949
S
D
W
S
R
G
R
T
T
G
A
A
P
Q
S
Site 15
T1950
D
W
S
R
G
R
T
T
G
A
A
P
Q
S
V
Site 16
S1961
P
Q
S
V
P
T
P
S
R
V
R
S
L
N
G
Site 17
S2444
G
V
L
P
P
R
L
S
S
A
T
P
T
S
L
Site 18
S2445
V
L
P
P
R
L
S
S
A
T
P
T
S
L
Q
Site 19
T2449
R
L
S
S
A
T
P
T
S
L
Q
V
V
W
S
Site 20
S2466
A
R
N
N
A
P
G
S
P
R
Y
Q
L
Q
M
Site 21
T2911
V
H
N
S
V
G
F
T
P
S
R
E
V
T
V
Site 22
T2919
P
S
R
E
V
T
V
T
T
L
A
G
L
P
E
Site 23
T2920
S
R
E
V
T
V
T
T
L
A
G
L
P
E
R
Site 24
T3494
S
K
A
V
R
A
R
T
K
E
D
V
P
Q
G
Site 25
T3508
G
V
S
P
P
T
W
T
K
I
D
N
L
E
D
Site 26
Y3623
S
N
G
V
I
K
E
Y
Q
I
R
Q
V
G
K
Site 27
Y3701
N
S
T
T
V
E
L
Y
W
S
L
P
E
K
P
Site 28
Y3745
N
L
E
P
N
S
R
Y
T
Y
K
L
E
V
K
Site 29
Y3747
E
P
N
S
R
Y
T
Y
K
L
E
V
K
T
G
Site 30
T4527
S
P
L
V
K
D
R
T
S
P
S
A
P
S
G
Site 31
S4528
P
L
V
K
D
R
T
S
P
S
A
P
S
G
M
Site 32
S5039
S
K
S
T
E
F
Y
S
E
L
W
F
I
V
L
Site 33
Y5072
R
K
I
H
K
E
P
Y
I
R
E
R
P
P
L
Site 34
S5087
V
P
L
Q
K
R
M
S
P
L
N
V
Y
P
P
Site 35
Y5092
R
M
S
P
L
N
V
Y
P
P
G
E
N
H
M
Site 36
T5104
N
H
M
G
L
A
D
T
K
I
P
R
S
G
T
Site 37
S5109
A
D
T
K
I
P
R
S
G
T
P
V
S
I
R
Site 38
T5111
T
K
I
P
R
S
G
T
P
V
S
I
R
S
N
Site 39
S5114
P
R
S
G
T
P
V
S
I
R
S
N
R
S
A
Site 40
S5128
A
C
V
L
R
I
P
S
Q
N
Q
T
S
L
T
Site 41
T5132
R
I
P
S
Q
N
Q
T
S
L
T
Y
S
Q
G
Site 42
S5133
I
P
S
Q
N
Q
T
S
L
T
Y
S
Q
G
S
Site 43
T5135
S
Q
N
Q
T
S
L
T
Y
S
Q
G
S
L
H
Site 44
S5137
N
Q
T
S
L
T
Y
S
Q
G
S
L
H
R
S
Site 45
S5140
S
L
T
Y
S
Q
G
S
L
H
R
S
V
S
Q
Site 46
S5144
S
Q
G
S
L
H
R
S
V
S
Q
L
M
D
I
Site 47
S5146
G
S
L
H
R
S
V
S
Q
L
M
D
I
Q
D
Site 48
Y5174
M
G
H
N
S
G
L
Y
V
D
E
E
D
L
M
Site 49
S5189
N
A
I
K
D
F
S
S
V
T
K
E
R
T
T
Site 50
T5196
S
V
T
K
E
R
T
T
F
T
D
T
H
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation