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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MED24
Full Name:
Mediator of RNA polymerase II transcription subunit 24
Alias:
100 kDa thyroid hormone receptor associated protein; Activator-recruited cofactor 100 kDa component; ARC100; Cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; CRSP100; CRSP4; DRIP100; KIAA0130; Mediator complex subunit 24; THRAP4; Thyroid hormone receptor-associated protein 4; Thyroid hormone receptor-associated protein complex 100 kDa component; TR100; TRAP100; Vitamin D3 receptor-interacting protein complex component DRIP100
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
110305
Number AA:
989
UniProt ID:
O75448
International Prot ID:
IPI00219430
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
Uniprot
OncoNet
Molecular Function:
GO:0016455
GO:0030374
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0006355
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y66
L
I
L
S
Y
L
K
Y
A
I
S
S
Q
M
V
Site 2
S69
S
Y
L
K
Y
A
I
S
S
Q
M
V
S
Y
S
Site 3
S70
Y
L
K
Y
A
I
S
S
Q
M
V
S
Y
S
S
Site 4
Y75
I
S
S
Q
M
V
S
Y
S
S
V
L
T
A
I
Site 5
S83
S
S
V
L
T
A
I
S
K
F
D
D
F
S
R
Site 6
S89
I
S
K
F
D
D
F
S
R
D
L
C
V
Q
A
Site 7
S138
L
L
R
C
T
A
A
S
A
E
R
L
R
E
G
Site 8
T150
R
E
G
L
E
A
G
T
P
A
A
G
E
K
Q
Site 9
T168
C
L
Q
R
L
E
K
T
L
S
S
T
K
N
R
Site 10
S170
Q
R
L
E
K
T
L
S
S
T
K
N
R
A
L
Site 11
T172
L
E
K
T
L
S
S
T
K
N
R
A
L
L
H
Site 12
S188
A
K
L
E
E
A
S
S
W
T
A
I
E
H
S
Site 13
S207
G
E
I
L
A
N
L
S
N
P
Q
L
R
S
Q
Site 14
S213
L
S
N
P
Q
L
R
S
Q
A
E
Q
C
G
T
Site 15
T220
S
Q
A
E
Q
C
G
T
L
I
R
S
I
P
T
Site 16
S230
R
S
I
P
T
M
L
S
V
H
A
E
Q
M
H
Site 17
T239
H
A
E
Q
M
H
K
T
G
F
P
T
V
H
A
Site 18
S262
N
L
T
G
E
T
Q
S
L
V
E
Q
L
T
M
Site 19
T268
Q
S
L
V
E
Q
L
T
M
V
K
R
M
Q
H
Site 20
T300
L
I
E
S
P
E
G
T
E
E
L
K
W
T
A
Site 21
T360
Q
R
C
N
C
D
C
T
N
F
L
L
Q
E
C
Site 22
S374
C
G
K
Q
G
L
L
S
E
A
S
V
N
N
L
Site 23
S377
Q
G
L
L
S
E
A
S
V
N
N
L
M
A
K
Site 24
S397
E
H
A
P
Q
Q
K
S
G
E
N
A
N
I
Q
Site 25
T418
L
R
A
E
P
T
V
T
N
I
L
K
T
M
D
Site 26
T423
T
V
T
N
I
L
K
T
M
D
A
D
H
S
K
Site 27
S429
K
T
M
D
A
D
H
S
K
S
P
E
G
L
L
Site 28
S431
M
D
A
D
H
S
K
S
P
E
G
L
L
G
V
Site 29
S444
G
V
L
G
H
M
L
S
G
K
S
L
D
L
L
Site 30
S447
G
H
M
L
S
G
K
S
L
D
L
L
L
A
A
Site 31
S463
A
A
T
G
K
L
K
S
F
A
R
K
F
I
N
Site 32
Y477
N
L
N
E
F
T
T
Y
G
S
E
E
S
T
K
Site 33
S482
T
T
Y
G
S
E
E
S
T
K
P
A
S
V
R
Site 34
T483
T
Y
G
S
E
E
S
T
K
P
A
S
V
R
A
Site 35
S487
E
E
S
T
K
P
A
S
V
R
A
L
L
F
D
Site 36
S514
Y
G
S
E
V
I
L
S
E
S
R
T
G
A
E
Site 37
S551
H
P
C
F
R
P
D
S
T
K
V
E
S
L
V
Site 38
T552
P
C
F
R
P
D
S
T
K
V
E
S
L
V
A
Site 39
S556
P
D
S
T
K
V
E
S
L
V
A
L
L
N
N
Site 40
S639
G
L
D
E
R
E
K
S
L
Q
M
I
R
Q
L
Site 41
S652
Q
L
A
G
P
L
F
S
E
N
T
L
Q
F
Y
Site 42
Y659
S
E
N
T
L
Q
F
Y
N
E
R
V
V
I
M
Site 43
T683
D
V
L
Q
Q
T
A
T
Q
I
K
F
P
S
T
Site 44
T690
T
Q
I
K
F
P
S
T
G
V
D
T
M
P
Y
Site 45
Y697
T
G
V
D
T
M
P
Y
W
N
L
L
P
P
K
Site 46
S726
L
E
K
G
W
V
D
S
R
S
I
H
I
F
D
Site 47
S728
K
G
W
V
D
S
R
S
I
H
I
F
D
T
L
Site 48
T761
K
E
T
R
K
E
H
T
L
R
A
V
E
L
L
Site 49
T793
H
I
L
P
G
L
L
T
D
S
S
K
W
H
S
Site 50
S795
L
P
G
L
L
T
D
S
S
K
W
H
S
L
M
Site 51
S796
P
G
L
L
T
D
S
S
K
W
H
S
L
M
D
Site 52
S800
T
D
S
S
K
W
H
S
L
M
D
P
P
G
T
Site 53
S820
A
V
W
C
A
L
S
S
Y
S
S
H
K
G
Q
Site 54
Y821
V
W
C
A
L
S
S
Y
S
S
H
K
G
Q
A
Site 55
S823
C
A
L
S
S
Y
S
S
H
K
G
Q
A
S
T
Site 56
S829
S
S
H
K
G
Q
A
S
T
R
Q
K
K
R
H
Site 57
Y843
H
R
E
D
I
E
D
Y
I
S
L
F
P
L
D
Site 58
S845
E
D
I
E
D
Y
I
S
L
F
P
L
D
D
V
Site 59
S855
P
L
D
D
V
Q
P
S
K
L
M
R
L
L
S
Site 60
S862
S
K
L
M
R
L
L
S
S
N
E
D
D
A
N
Site 61
S863
K
L
M
R
L
L
S
S
N
E
D
D
A
N
I
Site 62
S872
E
D
D
A
N
I
L
S
S
P
T
D
R
S
M
Site 63
S873
D
D
A
N
I
L
S
S
P
T
D
R
S
M
S
Site 64
T875
A
N
I
L
S
S
P
T
D
R
S
M
S
S
S
Site 65
S878
L
S
S
P
T
D
R
S
M
S
S
S
L
S
A
Site 66
S880
S
P
T
D
R
S
M
S
S
S
L
S
A
S
Q
Site 67
S881
P
T
D
R
S
M
S
S
S
L
S
A
S
Q
L
Site 68
S882
T
D
R
S
M
S
S
S
L
S
A
S
Q
L
H
Site 69
S884
R
S
M
S
S
S
L
S
A
S
Q
L
H
T
V
Site 70
S886
M
S
S
S
L
S
A
S
Q
L
H
T
V
N
M
Site 71
T890
L
S
A
S
Q
L
H
T
V
N
M
R
D
P
L
Site 72
T916
S
S
I
L
G
S
R
T
A
G
P
H
T
Q
F
Site 73
S942
L
E
Q
G
G
R
G
S
V
L
Q
F
M
P
F
Site 74
T971
P
K
V
V
L
A
I
T
D
L
S
L
P
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation