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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
E2F6
Full Name:
Transcription factor E2F6
Alias:
E2F transcription factor 6; E2F transcription factor 6, isoform 1; E2F-6
Type:
Transcription factor
Mass (Da):
31825
Number AA:
281
UniProt ID:
O75461
International Prot ID:
IPI00289560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
P
S
L
L
L
D
P
T
E
E
T
V
R
R
R
Site 2
T21
L
L
D
P
T
E
E
T
V
R
R
R
C
R
D
Site 3
S38
N
V
E
G
L
L
P
S
K
I
R
I
N
L
E
Site 4
Y50
N
L
E
D
N
V
Q
Y
V
S
M
R
K
A
L
Site 5
S52
E
D
N
V
Q
Y
V
S
M
R
K
A
L
K
V
Site 6
S67
K
R
P
R
F
D
V
S
L
V
Y
L
T
R
K
Site 7
Y70
R
F
D
V
S
L
V
Y
L
T
R
K
F
M
D
Site 8
Y104
G
V
R
K
R
R
V
Y
D
I
T
N
V
L
D
Site 9
T107
K
R
R
V
Y
D
I
T
N
V
L
D
G
I
D
Site 10
S132
R
W
I
G
S
D
L
S
N
F
G
A
V
P
Q
Site 11
S148
K
K
L
Q
E
E
L
S
D
L
S
A
M
E
D
Site 12
Y182
K
E
N
E
R
L
A
Y
V
T
Y
Q
D
I
H
Site 13
T184
N
E
R
L
A
Y
V
T
Y
Q
D
I
H
S
I
Site 14
Y185
E
R
L
A
Y
V
T
Y
Q
D
I
H
S
I
Q
Site 15
S219
V
P
A
P
R
E
D
S
I
T
V
H
I
R
S
Site 16
T221
A
P
R
E
D
S
I
T
V
H
I
R
S
T
N
Site 17
S226
S
I
T
V
H
I
R
S
T
N
G
P
I
D
V
Site 18
Y234
T
N
G
P
I
D
V
Y
L
C
E
V
E
Q
G
Site 19
T243
C
E
V
E
Q
G
Q
T
S
N
K
R
S
E
G
Site 20
S244
E
V
E
Q
G
Q
T
S
N
K
R
S
E
G
V
Site 21
S248
G
Q
T
S
N
K
R
S
E
G
V
G
T
S
S
Site 22
T253
K
R
S
E
G
V
G
T
S
S
S
E
S
T
H
Site 23
S254
R
S
E
G
V
G
T
S
S
S
E
S
T
H
P
Site 24
S255
S
E
G
V
G
T
S
S
S
E
S
T
H
P
E
Site 25
S256
E
G
V
G
T
S
S
S
E
S
T
H
P
E
G
Site 26
S258
V
G
T
S
S
S
E
S
T
H
P
E
G
P
E
Site 27
T259
G
T
S
S
S
E
S
T
H
P
E
G
P
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation