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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGR5
Full Name:
Leucine-rich repeat-containing G-protein coupled receptor 5
Alias:
FEX; GPR49; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; GRP49; HG38; Leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; Orphan G-protein coupled receptor HG38
Type:
Mass (Da):
99980
Number AA:
907
UniProt ID:
O75473
International Prot ID:
IPI00021131
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0016500
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
P
V
L
L
Q
L
A
T
G
G
S
S
P
R
S
Site 2
S27
T
G
G
S
S
P
R
S
G
V
L
L
R
G
C
Site 3
S58
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
Site 4
S65
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
Site 5
Y70
N
L
S
V
F
T
S
Y
L
D
L
S
M
N
N
Site 6
S74
F
T
S
Y
L
D
L
S
M
N
N
I
S
Q
L
Site 7
Y114
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Site 8
S139
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
Site 9
S142
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
Site 10
Y152
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
Site 11
S156
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
Site 12
S159
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
Site 13
S163
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
Site 14
Y204
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
Site 15
T238
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
Site 16
Y243
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
Site 17
T251
N
N
L
D
E
F
P
T
A
I
R
T
L
S
N
Site 18
T255
E
F
P
T
A
I
R
T
L
S
N
L
K
E
L
Site 19
S257
P
T
A
I
R
T
L
S
N
L
K
E
L
G
F
Site 20
S266
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
Site 21
T325
I
T
E
F
P
D
L
T
G
T
A
N
L
E
S
Site 22
S332
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
Site 23
T346
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
Site 24
S371
L
E
D
L
P
S
F
S
V
C
Q
K
L
Q
K
Site 25
Y387
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Site 26
S402
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
Site 27
S458
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
Site 28
S461
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
Site 29
S462
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
Site 30
S502
W
N
K
G
D
N
S
S
M
D
D
L
H
K
K
Site 31
S538
E
D
L
K
A
L
H
S
V
Q
C
S
P
S
P
Site 32
S542
A
L
H
S
V
Q
C
S
P
S
P
G
P
F
K
Site 33
S544
H
S
V
Q
C
S
P
S
P
G
P
F
K
P
C
Site 34
S590
F
R
S
P
L
Y
I
S
P
I
K
L
L
I
G
Site 35
S665
A
A
L
E
R
G
F
S
V
K
Y
S
A
K
F
Site 36
Y668
E
R
G
F
S
V
K
Y
S
A
K
F
E
T
K
Site 37
S669
R
G
F
S
V
K
Y
S
A
K
F
E
T
K
A
Site 38
T674
K
Y
S
A
K
F
E
T
K
A
P
F
S
S
L
Site 39
S721
P
L
P
F
G
E
P
S
T
M
G
Y
M
V
A
Site 40
T722
L
P
F
G
E
P
S
T
M
G
Y
M
V
A
L
Site 41
Y748
T
I
A
Y
T
K
L
Y
C
N
L
D
K
G
D
Site 42
S833
H
F
K
E
D
L
V
S
L
R
K
Q
T
Y
V
Site 43
T838
L
V
S
L
R
K
Q
T
Y
V
W
T
R
S
K
Site 44
Y839
V
S
L
R
K
Q
T
Y
V
W
T
R
S
K
H
Site 45
T842
R
K
Q
T
Y
V
W
T
R
S
K
H
P
S
L
Site 46
S844
Q
T
Y
V
W
T
R
S
K
H
P
S
L
M
S
Site 47
S848
W
T
R
S
K
H
P
S
L
M
S
I
N
S
D
Site 48
S851
S
K
H
P
S
L
M
S
I
N
S
D
D
V
E
Site 49
S854
P
S
L
M
S
I
N
S
D
D
V
E
K
Q
S
Site 50
T865
E
K
Q
S
C
D
S
T
Q
A
L
V
T
F
T
Site 51
T877
T
F
T
S
S
S
I
T
Y
D
L
P
P
S
S
Site 52
Y878
F
T
S
S
S
I
T
Y
D
L
P
P
S
S
V
Site 53
S883
I
T
Y
D
L
P
P
S
S
V
P
S
P
A
Y
Site 54
S884
T
Y
D
L
P
P
S
S
V
P
S
P
A
Y
P
Site 55
S887
L
P
P
S
S
V
P
S
P
A
Y
P
V
T
E
Site 56
Y890
S
S
V
P
S
P
A
Y
P
V
T
E
S
C
H
Site 57
T893
P
S
P
A
Y
P
V
T
E
S
C
H
L
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation