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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPC4
Full Name:
Glypican-4
Alias:
K-glypican
Type:
Mass (Da):
62412
Number AA:
556
UniProt ID:
O75487
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
L
L
A
A
E
L
K
S
K
S
C
S
E
V
R
Site 2
S29
A
A
E
L
K
S
K
S
C
S
E
V
R
R
L
Site 3
S31
E
L
K
S
K
S
C
S
E
V
R
R
L
Y
V
Site 4
Y37
C
S
E
V
R
R
L
Y
V
S
K
G
F
N
K
Site 5
S39
E
V
R
R
L
Y
V
S
K
G
F
N
K
N
D
Site 6
S64
L
K
I
C
P
Q
G
S
T
C
C
S
Q
E
M
Site 7
T65
K
I
C
P
Q
G
S
T
C
C
S
Q
E
M
E
Site 8
S68
P
Q
G
S
T
C
C
S
Q
E
M
E
E
K
Y
Site 9
Y75
S
Q
E
M
E
E
K
Y
S
L
Q
S
K
D
D
Site 10
S76
Q
E
M
E
E
K
Y
S
L
Q
S
K
D
D
F
Site 11
S79
E
E
K
Y
S
L
Q
S
K
D
D
F
K
S
V
Site 12
S85
Q
S
K
D
D
F
K
S
V
V
S
E
Q
C
N
Site 13
S119
L
L
E
N
A
E
K
S
L
N
D
M
F
V
K
Site 14
Y132
V
K
T
Y
G
H
L
Y
M
Q
N
S
E
L
F
Site 15
Y180
F
R
L
V
N
S
Q
Y
H
F
T
D
E
Y
L
Site 16
Y186
Q
Y
H
F
T
D
E
Y
L
E
C
V
S
K
Y
Site 17
Y193
Y
L
E
C
V
S
K
Y
T
E
Q
L
K
P
F
Site 18
T262
S
H
C
R
G
L
V
T
V
K
P
C
Y
N
Y
Site 19
S310
E
G
P
F
N
I
E
S
V
M
D
P
I
D
V
Site 20
S334
Q
D
N
S
V
Q
V
S
Q
K
V
F
Q
G
C
Site 21
S353
P
L
P
A
G
R
I
S
R
S
I
S
E
S
A
Site 22
S355
P
A
G
R
I
S
R
S
I
S
E
S
A
F
S
Site 23
S357
G
R
I
S
R
S
I
S
E
S
A
F
S
A
R
Site 24
S359
I
S
R
S
I
S
E
S
A
F
S
A
R
F
R
Site 25
S362
S
I
S
E
S
A
F
S
A
R
F
R
P
H
H
Site 26
T375
H
H
P
E
E
R
P
T
T
A
A
G
T
S
L
Site 27
T376
H
P
E
E
R
P
T
T
A
A
G
T
S
L
D
Site 28
T387
T
S
L
D
R
L
V
T
D
V
K
E
K
L
K
Site 29
S401
K
Q
A
K
K
F
W
S
S
L
P
S
N
V
C
Site 30
S402
Q
A
K
K
F
W
S
S
L
P
S
N
V
C
N
Site 31
S405
K
F
W
S
S
L
P
S
N
V
C
N
D
E
R
Site 32
Y432
N
G
K
G
K
S
R
Y
L
F
A
V
T
G
N
Site 33
T454
N
P
E
V
Q
V
D
T
S
K
P
D
I
L
I
Site 34
T472
I
M
A
L
R
V
M
T
S
K
M
K
N
A
Y
Site 35
S473
M
A
L
R
V
M
T
S
K
M
K
N
A
Y
N
Site 36
S490
D
V
D
F
F
D
I
S
D
E
S
S
G
E
G
Site 37
S493
F
F
D
I
S
D
E
S
S
G
E
G
S
G
S
Site 38
S494
F
D
I
S
D
E
S
S
G
E
G
S
G
S
G
Site 39
S498
D
E
S
S
G
E
G
S
G
S
G
C
E
Y
Q
Site 40
S500
S
S
G
E
G
S
G
S
G
C
E
Y
Q
Q
C
Site 41
Y504
G
S
G
S
G
C
E
Y
Q
Q
C
P
S
E
F
Site 42
Y513
Q
C
P
S
E
F
D
Y
N
A
T
D
H
A
G
Site 43
S522
A
T
D
H
A
G
K
S
A
N
E
K
A
D
S
Site 44
S529
S
A
N
E
K
A
D
S
A
G
V
R
P
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation