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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SF3B1
Full Name:
Splicing factor 3B subunit 1
Alias:
Pre-mRNA-splicing factor SF3b 155 kDa subunit; S3B1; SAP155; SF3b155; Spliceosome associated protein 155; Spliceosome-associated protein 155
Type:
RNA binding protein
Mass (Da):
145830
Number AA:
1304
UniProt ID:
O75533
International Prot ID:
IPI00026089
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
GO:0005681
GO:0016604
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003682
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
A
Q
G
V
G
L
D
S
T
G
Y
Y
D
Q
E
Site 2
T36
Q
G
V
G
L
D
S
T
G
Y
Y
D
Q
E
I
Site 3
Y38
V
G
L
D
S
T
G
Y
Y
D
Q
E
I
Y
G
Site 4
Y39
G
L
D
S
T
G
Y
Y
D
Q
E
I
Y
G
G
Site 5
Y44
G
Y
Y
D
Q
E
I
Y
G
G
S
D
S
R
F
Site 6
S47
D
Q
E
I
Y
G
G
S
D
S
R
F
A
G
Y
Site 7
S49
E
I
Y
G
G
S
D
S
R
F
A
G
Y
V
T
Site 8
T61
Y
V
T
S
I
A
A
T
E
L
E
D
D
D
D
Site 9
Y70
L
E
D
D
D
D
D
Y
S
S
S
T
S
L
L
Site 10
S71
E
D
D
D
D
D
Y
S
S
S
T
S
L
L
G
Site 11
S72
D
D
D
D
D
Y
S
S
S
T
S
L
L
G
Q
Site 12
S73
D
D
D
D
Y
S
S
S
T
S
L
L
G
Q
K
Site 13
S75
D
D
Y
S
S
S
T
S
L
L
G
Q
K
K
P
Site 14
Y84
L
G
Q
K
K
P
G
Y
H
A
P
V
A
L
L
Site 15
S97
L
L
N
D
I
P
Q
S
T
E
Q
Y
D
P
F
Site 16
Y101
I
P
Q
S
T
E
Q
Y
D
P
F
A
E
H
R
Site 17
Y119
I
A
D
R
E
D
E
Y
K
K
H
R
R
T
M
Site 18
T125
E
Y
K
K
H
R
R
T
M
I
I
S
P
E
R
Site 19
S129
H
R
R
T
M
I
I
S
P
E
R
L
D
P
F
Site 20
T142
P
F
A
D
G
G
K
T
P
D
P
K
M
N
V
Site 21
Y152
P
K
M
N
V
R
T
Y
M
D
V
M
R
E
Q
Site 22
T162
V
M
R
E
Q
H
L
T
K
E
E
R
E
I
R
Site 23
S190
V
V
N
G
A
A
A
S
Q
P
P
S
K
R
K
Site 24
S194
A
A
A
S
Q
P
P
S
K
R
K
R
R
W
D
Site 25
T203
R
K
R
R
W
D
Q
T
A
D
Q
T
P
G
A
Site 26
T207
W
D
Q
T
A
D
Q
T
P
G
A
T
P
K
K
Site 27
T211
A
D
Q
T
P
G
A
T
P
K
K
L
S
S
W
Site 28
S216
G
A
T
P
K
K
L
S
S
W
D
Q
A
E
T
Site 29
S217
A
T
P
K
K
L
S
S
W
D
Q
A
E
T
P
Site 30
T223
S
S
W
D
Q
A
E
T
P
G
H
T
P
S
L
Site 31
T227
Q
A
E
T
P
G
H
T
P
S
L
R
W
D
E
Site 32
S229
E
T
P
G
H
T
P
S
L
R
W
D
E
T
P
Site 33
T235
P
S
L
R
W
D
E
T
P
G
R
A
K
G
S
Site 34
S242
T
P
G
R
A
K
G
S
E
T
P
G
A
T
P
Site 35
T244
G
R
A
K
G
S
E
T
P
G
A
T
P
G
S
Site 36
T248
G
S
E
T
P
G
A
T
P
G
S
K
I
W
D
Site 37
S251
T
P
G
A
T
P
G
S
K
I
W
D
P
T
P
Site 38
T257
G
S
K
I
W
D
P
T
P
S
H
T
P
A
G
Site 39
S259
K
I
W
D
P
T
P
S
H
T
P
A
G
A
A
Site 40
T261
W
D
P
T
P
S
H
T
P
A
G
A
A
T
P
Site 41
T267
H
T
P
A
G
A
A
T
P
G
R
G
D
T
P
Site 42
T273
A
T
P
G
R
G
D
T
P
G
H
A
T
P
G
Site 43
T278
G
D
T
P
G
H
A
T
P
G
H
G
G
A
T
Site 44
T285
T
P
G
H
G
G
A
T
S
S
A
R
K
N
R
Site 45
S286
P
G
H
G
G
A
T
S
S
A
R
K
N
R
W
Site 46
S287
G
H
G
G
A
T
S
S
A
R
K
N
R
W
D
Site 47
T296
R
K
N
R
W
D
E
T
P
K
T
E
R
D
T
Site 48
T299
R
W
D
E
T
P
K
T
E
R
D
T
P
G
H
Site 49
T303
T
P
K
T
E
R
D
T
P
G
H
G
S
G
W
Site 50
S308
R
D
T
P
G
H
G
S
G
W
A
E
T
P
R
Site 51
T313
H
G
S
G
W
A
E
T
P
R
T
D
R
G
G
Site 52
T316
G
W
A
E
T
P
R
T
D
R
G
G
D
S
I
Site 53
S322
R
T
D
R
G
G
D
S
I
G
E
T
P
T
P
Site 54
T326
G
G
D
S
I
G
E
T
P
T
P
G
A
S
K
Site 55
T328
D
S
I
G
E
T
P
T
P
G
A
S
K
R
K
Site 56
S332
E
T
P
T
P
G
A
S
K
R
K
S
R
W
D
Site 57
S336
P
G
A
S
K
R
K
S
R
W
D
E
T
P
A
Site 58
T341
R
K
S
R
W
D
E
T
P
A
S
Q
M
G
G
Site 59
S344
R
W
D
E
T
P
A
S
Q
M
G
G
S
T
P
Site 60
S349
P
A
S
Q
M
G
G
S
T
P
V
L
T
P
G
Site 61
T350
A
S
Q
M
G
G
S
T
P
V
L
T
P
G
K
Site 62
T354
G
G
S
T
P
V
L
T
P
G
K
T
P
I
G
Site 63
T362
P
G
K
T
P
I
G
T
P
A
M
N
M
A
T
Site 64
T369
T
P
A
M
N
M
A
T
P
T
P
G
H
I
M
Site 65
S377
P
T
P
G
H
I
M
S
M
T
P
E
Q
L
Q
Site 66
T379
P
G
H
I
M
S
M
T
P
E
Q
L
Q
A
W
Site 67
S400
D
E
R
N
R
P
L
S
D
E
E
L
D
A
M
Site 68
Y421
V
L
P
P
P
A
G
Y
V
P
I
R
T
P
A
Site 69
T426
A
G
Y
V
P
I
R
T
P
A
R
K
L
T
A
Site 70
T432
R
T
P
A
R
K
L
T
A
T
P
T
P
L
G
Site 71
T434
P
A
R
K
L
T
A
T
P
T
P
L
G
G
M
Site 72
T436
R
K
L
T
A
T
P
T
P
L
G
G
M
T
G
Site 73
T442
P
T
P
L
G
G
M
T
G
F
H
M
Q
T
E
Site 74
S455
T
E
D
R
T
M
K
S
V
N
D
Q
P
S
G
Site 75
S461
K
S
V
N
D
Q
P
S
G
N
L
P
F
L
K
Site 76
Y474
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Site 77
S485
L
L
V
D
V
D
E
S
T
L
S
P
E
E
Q
Site 78
T486
L
V
D
V
D
E
S
T
L
S
P
E
E
Q
K
Site 79
S488
D
V
D
E
S
T
L
S
P
E
E
Q
K
E
R
Site 80
T508
L
L
K
I
K
N
G
T
P
P
M
R
K
A
A
Site 81
T520
K
A
A
L
R
Q
I
T
D
K
A
R
E
F
G
Site 82
S541
Q
I
L
P
L
L
M
S
P
T
L
E
D
Q
E
Site 83
T543
L
P
L
L
M
S
P
T
L
E
D
Q
E
R
H
Site 84
Y561
K
V
I
D
R
I
L
Y
K
L
D
D
L
V
R
Site 85
Y587
P
L
L
I
D
E
D
Y
Y
A
R
V
E
G
L
Site 86
Y588
L
L
I
D
E
D
Y
Y
A
R
V
E
G
L
E
Site 87
T608
A
K
A
A
G
L
A
T
M
I
S
T
M
R
P
Site 88
Y623
D
I
D
N
M
D
E
Y
V
R
N
T
T
A
R
Site 89
T627
M
D
E
Y
V
R
N
T
T
A
R
A
F
A
V
Site 90
T628
D
E
Y
V
R
N
T
T
A
R
A
F
A
V
V
Site 91
S657
A
V
C
K
S
K
K
S
W
Q
A
R
H
T
G
Site 92
T663
K
S
W
Q
A
R
H
T
G
I
K
I
V
Q
Q
Site 93
S723
A
T
P
Y
G
I
E
S
F
D
S
V
L
K
P
Site 94
S726
Y
G
I
E
S
F
D
S
V
L
K
P
L
W
K
Site 95
Y761
I
P
L
M
D
A
E
Y
A
N
Y
Y
T
R
E
Site 96
Y764
M
D
A
E
Y
A
N
Y
Y
T
R
E
V
M
L
Site 97
Y765
D
A
E
Y
A
N
Y
Y
T
R
E
V
M
L
I
Site 98
S779
I
L
I
R
E
F
Q
S
P
D
E
E
M
K
K
Site 99
T808
V
E
A
N
Y
I
K
T
E
I
L
P
P
F
F
Site 100
Y830
M
A
L
D
R
R
N
Y
R
Q
L
V
D
T
T
Site 101
T836
N
Y
R
Q
L
V
D
T
T
V
E
L
A
N
K
Site 102
T837
Y
R
Q
L
V
D
T
T
V
E
L
A
N
K
V
Site 103
S851
V
G
A
A
E
I
I
S
R
I
V
D
D
L
K
Site 104
Y864
L
K
D
E
A
E
Q
Y
R
K
M
V
M
E
T
Site 105
S908
Q
E
Q
T
T
E
D
S
V
M
L
N
G
F
G
Site 106
Y928
L
G
K
R
V
K
P
Y
L
P
Q
I
C
G
T
Site 107
S944
L
W
R
L
N
N
K
S
A
K
V
R
Q
Q
A
Site 108
Y981
L
G
V
V
L
Y
E
Y
L
G
E
E
Y
P
E
Site 109
Y986
Y
E
Y
L
G
E
E
Y
P
E
V
L
G
S
I
Site 110
T1021
K
D
L
L
P
R
L
T
P
I
L
K
N
R
H
Site 111
Y1049
I
A
D
R
G
A
E
Y
V
S
A
R
E
W
M
Site 112
S1051
D
R
G
A
E
Y
V
S
A
R
E
W
M
R
I
Site 113
T1077
K
K
A
I
R
R
A
T
V
N
T
F
G
Y
I
Site 114
Y1136
L
P
A
L
M
N
E
Y
R
V
P
E
L
N
V
Site 115
Y1157
S
L
S
F
L
F
E
Y
I
G
E
M
G
K
D
Site 116
Y1167
E
M
G
K
D
Y
I
Y
A
V
T
P
L
L
E
Site 117
T1187
R
D
L
V
H
R
Q
T
A
S
A
V
V
Q
H
Site 118
Y1200
Q
H
M
S
L
G
V
Y
G
F
G
C
E
D
S
Site 119
Y1214
S
L
N
H
L
L
N
Y
V
W
P
N
V
F
E
Site 120
Y1265
A
R
K
V
R
D
V
Y
W
K
I
Y
N
S
I
Site 121
Y1269
R
D
V
Y
W
K
I
Y
N
S
I
Y
I
G
S
Site 122
Y1284
Q
D
A
L
I
A
H
Y
P
R
I
Y
N
D
D
Site 123
Y1288
I
A
H
Y
P
R
I
Y
N
D
D
K
N
T
Y
Site 124
Y1295
Y
N
D
D
K
N
T
Y
I
R
Y
E
L
D
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation