PhosphoNET

           
Protein Info 
   
Short Name:  DAB1
Full Name:  Disabled homolog 1
Alias:  Disabled 1
Type:  Adapter/scaffold protein
Mass (Da):  63775
Number AA:  588
UniProt ID:  O75553
International Prot ID:  IPI00026889
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S27RKKGQDRSEATLIKR
Site 2Y42FKGEGVRYKAKLIGI
Site 3T101IKIFDEKTGALQHHH
Site 4T121SYIAKDITDHRAFGY
Site 5Y128TDHRAFGYVCGKEGN
Site 6Y162RDLFQLIYELKQREE
Site 7Y185KQCEQAVYQTILEED
Site 8Y198EDVEDPVYQYIVFEA
Site 9Y200VEDPVYQYIVFEAGH
Site 10T215EPIRDPETEENIYQV
Site 11Y220PETEENIYQVPTSQK
Site 12S225NIYQVPTSQKKEGVY
Site 13Y232SQKKEGVYDVPKSQP
Site 14S237GVYDVPKSQPVSNGY
Site 15S241VPKSQPVSNGYSFED
Site 16S245QPVSNGYSFEDFEER
Site 17T257EERFAAATPNRNLPT
Site 18S286LELFGDMSTPPDITS
Site 19T287ELFGDMSTPPDITSP
Site 20T292MSTPPDITSPPTPAT
Site 21S293STPPDITSPPTPATP
Site 22T296PDITSPPTPATPGDA
Site 23T299TSPPTPATPGDAFIP
Site 24S307PGDAFIPSSSQTLPA
Site 25S308GDAFIPSSSQTLPAS
Site 26S309DAFIPSSSQTLPASA
Site 27T383QPGLFPATQQPWPTV
Site 28T389ATQQPWPTVAGQFPP
Site 29T418AMFQGPLTPLATVPG
Site 30T422GPLTPLATVPGTSDS
Site 31T426PLATVPGTSDSTRSS
Site 32S427LATVPGTSDSTRSSP
Site 33S429TVPGTSDSTRSSPQT
Site 34S433TSDSTRSSPQTDKPR
Site 35T436STRSSPQTDKPRQKM
Site 36T447RQKMGKETFKDFQMA
Site 37S461AQPPPVPSRKPDQPS
Site 38S468SRKPDQPSLTCTSEA
Site 39T470KPDQPSLTCTSEAFS
Site 40T472DQPSLTCTSEAFSSY
Site 41S473QPSLTCTSEAFSSYF
Site 42S477TCTSEAFSSYFNKVG
Site 43S478CTSEAFSSYFNKVGV
Site 44Y479TSEAFSSYFNKVGVA
Site 45T489KVGVAQDTDDCDDFD
Site 46S498DCDDFDISQLNLTPV
Site 47T503DISQLNLTPVTSTTP
Site 48T506QLNLTPVTSTTPSTN
Site 49S507LNLTPVTSTTPSTNS
Site 50T509LTPVTSTTPSTNSPP
Site 51S511PVTSTTPSTNSPPTP
Site 52T512VTSTTPSTNSPPTPA
Site 53S514STTPSTNSPPTPAPR
Site 54T517PSTNSPPTPAPRQSS
Site 55S523PTPAPRQSSPSKSSA
Site 56S524TPAPRQSSPSKSSAS
Site 57S526APRQSSPSKSSASHA
Site 58S528RQSSPSKSSASHASD
Site 59S529QSSPSKSSASHASDP
Site 60S531SPSKSSASHASDPTT
Site 61T538SHASDPTTDDIFEEG
Site 62S548IFEEGFESPSKSEEQ
Site 63S550EEGFESPSKSEEQEA
Site 64S552GFESPSKSEEQEAPD
Site 65S561EQEAPDGSQASSNSD
Site 66S564APDGSQASSNSDPFG
Site 67S565PDGSQASSNSDPFGE
Site 68S567GSQASSNSDPFGEPS
Site 69S574SDPFGEPSGEPSGDN
Site 70S578GEPSGEPSGDNISPQ
Site 71S583EPSGDNISPQAGS__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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