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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RA70
Full Name:
Src kinase-associated phosphoprotein 2
Alias:
Pyk2,RAFTK-associated protein; Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; Retinoic acid-induced protein 79; SAPS; SCAP2; SKAP2; SKAP55; SKAP-55HOM; SKAP55R; SKAP-HOM; Src family-associated phosphoprotein 2; Src kinase associated phosphoprotein 2; SRC-associated adaptor protein with PH and SH3 domains
Type:
Adapter/scaffold protein
Mass (Da):
41217
Number AA:
359
UniProt ID:
O75563
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0042113
GO:0006461
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
P
N
P
S
S
T
S
S
P
Y
P
Site 2
S6
_
_
M
P
N
P
S
S
T
S
S
P
Y
P
L
Site 3
T7
_
M
P
N
P
S
S
T
S
S
P
Y
P
L
P
Site 4
S9
P
N
P
S
S
T
S
S
P
Y
P
L
P
E
E
Site 5
Y11
P
S
S
T
S
S
P
Y
P
L
P
E
E
I
R
Site 6
S47
K
A
K
E
K
R
E
S
L
I
K
K
I
K
D
Site 7
S57
K
K
I
K
D
V
K
S
I
Y
L
Q
E
F
Q
Site 8
Y59
I
K
D
V
K
S
I
Y
L
Q
E
F
Q
D
K
Site 9
Y75
D
A
E
D
G
E
E
Y
D
D
P
F
A
G
P
Site 10
T85
P
F
A
G
P
P
D
T
I
S
L
A
S
E
R
Site 11
S87
A
G
P
P
D
T
I
S
L
A
S
E
R
Y
D
Site 12
S90
P
D
T
I
S
L
A
S
E
R
Y
D
K
D
D
Site 13
Y122
P
F
V
L
K
A
G
Y
L
E
K
R
R
K
D
Site 14
S131
E
K
R
R
K
D
H
S
F
L
G
F
E
W
Q
Site 15
T147
R
W
C
A
L
S
K
T
V
F
Y
Y
Y
G
S
Site 16
Y150
A
L
S
K
T
V
F
Y
Y
Y
G
S
D
K
D
Site 17
Y151
L
S
K
T
V
F
Y
Y
Y
G
S
D
K
D
K
Site 18
Y152
S
K
T
V
F
Y
Y
Y
G
S
D
K
D
K
Q
Site 19
S154
T
V
F
Y
Y
Y
G
S
D
K
D
K
Q
Q
K
Site 20
Y169
G
E
F
A
I
D
G
Y
S
V
R
M
N
N
T
Site 21
T176
Y
S
V
R
M
N
N
T
L
R
K
D
G
K
K
Site 22
Y197
S
A
P
D
K
R
I
Y
Q
F
T
A
A
S
P
Site 23
T200
D
K
R
I
Y
Q
F
T
A
A
S
P
K
D
A
Site 24
S203
I
Y
Q
F
T
A
A
S
P
K
D
A
E
E
W
Site 25
S223
F
V
L
Q
D
M
E
S
D
I
I
P
E
D
Y
Site 26
Y230
S
D
I
I
P
E
D
Y
D
E
R
G
E
L
Y
Site 27
Y237
Y
D
E
R
G
E
L
Y
D
D
V
D
H
P
L
Site 28
S247
V
D
H
P
L
P
I
S
N
P
L
T
S
S
Q
Site 29
T251
L
P
I
S
N
P
L
T
S
S
Q
P
I
D
D
Site 30
S253
I
S
N
P
L
T
S
S
Q
P
I
D
D
E
I
Site 31
Y261
Q
P
I
D
D
E
I
Y
E
E
L
P
E
E
E
Site 32
S271
L
P
E
E
E
E
D
S
A
P
V
K
V
E
E
Site 33
S283
V
E
E
Q
R
K
M
S
Q
D
S
V
H
H
T
Site 34
S286
Q
R
K
M
S
Q
D
S
V
H
H
T
S
G
D
Site 35
T290
S
Q
D
S
V
H
H
T
S
G
D
K
S
T
D
Site 36
S291
Q
D
S
V
H
H
T
S
G
D
K
S
T
D
Y
Site 37
Y298
S
G
D
K
S
T
D
Y
A
N
F
Y
Q
G
L
Site 38
Y302
S
T
D
Y
A
N
F
Y
Q
G
L
W
D
C
T
Site 39
S313
W
D
C
T
G
A
F
S
D
E
L
S
F
K
R
Site 40
S317
G
A
F
S
D
E
L
S
F
K
R
G
D
V
I
Site 41
Y325
F
K
R
G
D
V
I
Y
I
L
S
K
E
Y
N
Site 42
S328
G
D
V
I
Y
I
L
S
K
E
Y
N
R
Y
G
Site 43
Y331
I
Y
I
L
S
K
E
Y
N
R
Y
G
W
W
V
Site 44
Y334
L
S
K
E
Y
N
R
Y
G
W
W
V
G
E
M
Site 45
Y357
K
A
Y
I
M
E
M
Y
D
I
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation