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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTRF1
Full Name:
Peptide chain release factor 1, mitochondrial
Alias:
Mitochondrial translational release factor 1; Mitochontrial peptide chain release factor 1; MRF-1; MTTRF1; RF1; RF1M
Type:
Mitochondrial
Mass (Da):
52306
Number AA:
445
UniProt ID:
O75570
International Prot ID:
IPI00026157
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0016149
PhosphoSite+
KinaseNET
Biological Process:
GO:0006449
GO:0006415
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
R
H
P
S
L
N
G
Y
L
Q
C
H
I
Q
L
Site 2
S27
Q
C
H
I
Q
L
H
S
H
Q
F
R
Q
I
H
Site 3
Y78
K
H
K
A
L
Q
K
Y
M
E
N
L
S
K
E
Site 4
S83
Q
K
Y
M
E
N
L
S
K
E
Y
Q
T
L
E
Site 5
S105
V
N
E
E
N
R
R
S
L
N
R
R
H
A
E
Site 6
Y120
L
A
P
L
A
A
I
Y
Q
E
I
Q
E
T
E
Site 7
T126
I
Y
Q
E
I
Q
E
T
E
Q
A
I
E
E
L
Site 8
S135
Q
A
I
E
E
L
E
S
M
C
K
S
L
N
K
Site 9
S139
E
L
E
S
M
C
K
S
L
N
K
Q
D
E
K
Site 10
T158
L
A
L
E
E
R
Q
T
I
D
Q
K
I
N
M
Site 11
Y167
D
Q
K
I
N
M
L
Y
N
E
L
F
Q
S
L
Site 12
S173
L
Y
N
E
L
F
Q
S
L
V
P
K
E
K
Y
Site 13
Y180
S
L
V
P
K
E
K
Y
D
K
N
D
V
I
L
Site 14
T190
N
D
V
I
L
E
V
T
A
G
R
T
T
G
G
Site 15
T195
E
V
T
A
G
R
T
T
G
G
D
I
C
Q
Q
Site 16
Y211
T
R
E
I
F
D
M
Y
Q
N
Y
S
C
Y
K
Site 17
Y227
W
Q
F
E
L
L
N
Y
T
P
A
D
Y
G
G
Site 18
T228
Q
F
E
L
L
N
Y
T
P
A
D
Y
G
G
L
Site 19
Y232
L
N
Y
T
P
A
D
Y
G
G
L
H
H
A
A
Site 20
S243
H
H
A
A
A
R
I
S
G
D
G
V
Y
K
H
Site 21
Y248
R
I
S
G
D
G
V
Y
K
H
L
K
Y
E
G
Site 22
Y253
G
V
Y
K
H
L
K
Y
E
G
G
I
H
R
V
Site 23
S269
R
I
P
E
V
G
L
S
S
R
M
Q
R
I
H
Site 24
T277
S
R
M
Q
R
I
H
T
G
T
M
S
V
I
V
Site 25
T304
P
K
D
L
R
I
D
T
F
R
A
K
G
A
G
Site 26
T318
G
G
Q
H
V
N
K
T
D
S
A
V
R
L
V
Site 27
S320
Q
H
V
N
K
T
D
S
A
V
R
L
V
H
I
Site 28
Y357
R
V
L
R
A
R
L
Y
Q
Q
I
I
E
K
D
Site 29
S370
K
D
K
R
Q
Q
Q
S
A
R
K
L
Q
V
G
Site 30
S382
Q
V
G
T
R
A
Q
S
E
R
I
R
T
Y
N
Site 31
T387
A
Q
S
E
R
I
R
T
Y
N
F
T
Q
D
R
Site 32
Y388
Q
S
E
R
I
R
T
Y
N
F
T
Q
D
R
V
Site 33
T391
R
I
R
T
Y
N
F
T
Q
D
R
V
S
D
H
Site 34
S396
N
F
T
Q
D
R
V
S
D
H
R
I
A
Y
E
Site 35
Y402
V
S
D
H
R
I
A
Y
E
V
R
D
I
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation