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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP2
Full Name:
Ubiquitin carboxyl-terminal hydrolase 2
Alias:
41 kDa ubiquitin-specific protease;Deubiquitinating enzyme 2;Ubiquitin thiolesterase 2;Ubiquitin-specific-processing protease 2
Type:
Mass (Da):
68072
Number AA:
605
UniProt ID:
O75604
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
Q
L
S
S
T
L
K
R
Y
T
E
Site 2
T7
_
M
S
Q
L
S
S
T
L
K
R
Y
T
E
S
Site 3
T12
S
S
T
L
K
R
Y
T
E
S
A
R
Y
T
D
Site 4
S14
T
L
K
R
Y
T
E
S
A
R
Y
T
D
A
H
Site 5
Y17
R
Y
T
E
S
A
R
Y
T
D
A
H
Y
A
K
Site 6
T18
Y
T
E
S
A
R
Y
T
D
A
H
Y
A
K
S
Site 7
Y22
A
R
Y
T
D
A
H
Y
A
K
S
G
Y
G
A
Site 8
S25
T
D
A
H
Y
A
K
S
G
Y
G
A
Y
T
P
Site 9
Y27
A
H
Y
A
K
S
G
Y
G
A
Y
T
P
S
S
Site 10
Y30
A
K
S
G
Y
G
A
Y
T
P
S
S
Y
G
A
Site 11
T31
K
S
G
Y
G
A
Y
T
P
S
S
Y
G
A
N
Site 12
S33
G
Y
G
A
Y
T
P
S
S
Y
G
A
N
L
A
Site 13
S34
Y
G
A
Y
T
P
S
S
Y
G
A
N
L
A
A
Site 14
S57
G
F
K
P
V
P
T
S
S
F
L
T
R
P
R
Site 15
S58
F
K
P
V
P
T
S
S
F
L
T
R
P
R
T
Site 16
T61
V
P
T
S
S
F
L
T
R
P
R
T
Y
G
P
Site 17
T65
S
F
L
T
R
P
R
T
Y
G
P
S
S
L
L
Site 18
Y66
F
L
T
R
P
R
T
Y
G
P
S
S
L
L
D
Site 19
S69
R
P
R
T
Y
G
P
S
S
L
L
D
Y
D
R
Site 20
S70
P
R
T
Y
G
P
S
S
L
L
D
Y
D
R
G
Site 21
Y74
G
P
S
S
L
L
D
Y
D
R
G
R
P
L
L
Site 22
S94
G
G
G
K
R
A
E
S
Q
T
R
G
T
E
R
Site 23
T96
G
K
R
A
E
S
Q
T
R
G
T
E
R
P
L
Site 24
T99
A
E
S
Q
T
R
G
T
E
R
P
L
G
S
G
Site 25
S105
G
T
E
R
P
L
G
S
G
L
S
G
G
S
G
Site 26
S108
R
P
L
G
S
G
L
S
G
G
S
G
F
P
Y
Site 27
S111
G
S
G
L
S
G
G
S
G
F
P
Y
G
V
T
Site 28
Y115
S
G
G
S
G
F
P
Y
G
V
T
N
N
C
L
Site 29
Y124
V
T
N
N
C
L
S
Y
L
P
I
N
A
Y
D
Site 30
Y130
S
Y
L
P
I
N
A
Y
D
Q
G
V
T
L
T
Site 31
S142
T
L
T
Q
K
L
D
S
Q
S
D
L
A
R
D
Site 32
S144
T
Q
K
L
D
S
Q
S
D
L
A
R
D
F
S
Site 33
S151
S
D
L
A
R
D
F
S
S
L
R
T
S
D
S
Site 34
S152
D
L
A
R
D
F
S
S
L
R
T
S
D
S
Y
Site 35
T155
R
D
F
S
S
L
R
T
S
D
S
Y
R
I
D
Site 36
S156
D
F
S
S
L
R
T
S
D
S
Y
R
I
D
P
Site 37
S158
S
S
L
R
T
S
D
S
Y
R
I
D
P
R
N
Site 38
Y159
S
L
R
T
S
D
S
Y
R
I
D
P
R
N
L
Site 39
S169
D
P
R
N
L
G
R
S
P
M
L
A
R
T
R
Site 40
T181
R
T
R
K
E
L
C
T
L
Q
G
L
Y
Q
T
Site 41
S190
Q
G
L
Y
Q
T
A
S
C
P
E
Y
L
V
D
Site 42
Y194
Q
T
A
S
C
P
E
Y
L
V
D
Y
L
E
N
Site 43
Y198
C
P
E
Y
L
V
D
Y
L
E
N
Y
G
R
K
Site 44
Y202
L
V
D
Y
L
E
N
Y
G
R
K
G
S
A
S
Site 45
S207
E
N
Y
G
R
K
G
S
A
S
Q
V
P
S
Q
Site 46
S209
Y
G
R
K
G
S
A
S
Q
V
P
S
Q
A
P
Site 47
S213
G
S
A
S
Q
V
P
S
Q
A
P
P
S
R
V
Site 48
S218
V
P
S
Q
A
P
P
S
R
V
P
E
I
I
S
Site 49
S225
S
R
V
P
E
I
I
S
P
T
Y
R
P
I
G
Site 50
T227
V
P
E
I
I
S
P
T
Y
R
P
I
G
R
Y
Site 51
Y228
P
E
I
I
S
P
T
Y
R
P
I
G
R
Y
T
Site 52
Y234
T
Y
R
P
I
G
R
Y
T
L
W
E
T
G
K
Site 53
T235
Y
R
P
I
G
R
Y
T
L
W
E
T
G
K
G
Site 54
S248
K
G
Q
A
P
G
P
S
R
S
S
S
P
G
R
Site 55
S250
Q
A
P
G
P
S
R
S
S
S
P
G
R
D
G
Site 56
S251
A
P
G
P
S
R
S
S
S
P
G
R
D
G
M
Site 57
S252
P
G
P
S
R
S
S
S
P
G
R
D
G
M
N
Site 58
S260
P
G
R
D
G
M
N
S
K
S
A
Q
G
L
A
Site 59
S262
R
D
G
M
N
S
K
S
A
Q
G
L
A
G
L
Site 60
S286
N
S
I
L
Q
C
L
S
N
T
R
E
L
R
D
Site 61
Y294
N
T
R
E
L
R
D
Y
C
L
Q
R
L
Y
M
Site 62
Y300
D
Y
C
L
Q
R
L
Y
M
R
D
L
H
H
G
Site 63
T312
H
H
G
S
N
A
H
T
A
L
V
E
E
F
A
Site 64
T324
E
F
A
K
L
I
Q
T
I
W
T
S
S
P
N
Site 65
S329
I
Q
T
I
W
T
S
S
P
N
D
V
V
S
P
Site 66
S335
S
S
P
N
D
V
V
S
P
S
E
F
K
T
Q
Site 67
S337
P
N
D
V
V
S
P
S
E
F
K
T
Q
I
Q
Site 68
T341
V
S
P
S
E
F
K
T
Q
I
Q
R
Y
A
P
Site 69
Y346
F
K
T
Q
I
Q
R
Y
A
P
R
F
V
G
Y
Site 70
T377
H
N
E
V
N
R
V
T
L
R
P
K
S
N
P
Site 71
S382
R
V
T
L
R
P
K
S
N
P
E
N
L
D
H
Site 72
Y403
G
R
Q
M
W
R
K
Y
L
E
R
E
D
S
R
Site 73
S409
K
Y
L
E
R
E
D
S
R
I
G
D
L
F
V
Site 74
T424
G
Q
L
K
S
S
L
T
C
T
D
C
G
Y
C
Site 75
T426
L
K
S
S
L
T
C
T
D
C
G
Y
C
S
T
Site 76
S442
F
D
P
F
W
D
L
S
L
P
I
A
K
R
G
Site 77
Y450
L
P
I
A
K
R
G
Y
P
E
V
T
L
M
D
Site 78
T454
K
R
G
Y
P
E
V
T
L
M
D
C
M
R
L
Site 79
T463
M
D
C
M
R
L
F
T
K
E
D
V
L
D
G
Site 80
S490
K
R
C
I
K
K
F
S
I
Q
R
F
P
K
I
Site 81
S506
V
L
H
L
K
R
F
S
E
S
R
I
R
T
S
Site 82
S508
H
L
K
R
F
S
E
S
R
I
R
T
S
K
L
Site 83
T512
F
S
E
S
R
I
R
T
S
K
L
T
T
F
V
Site 84
S513
S
E
S
R
I
R
T
S
K
L
T
T
F
V
N
Site 85
T516
R
I
R
T
S
K
L
T
T
F
V
N
F
P
L
Site 86
T517
I
R
T
S
K
L
T
T
F
V
N
F
P
L
R
Site 87
S533
L
D
L
R
E
F
A
S
E
N
T
N
H
A
V
Site 88
Y544
N
H
A
V
Y
N
L
Y
A
V
S
N
H
S
G
Site 89
Y561
M
G
G
H
Y
T
A
Y
C
R
S
P
G
T
G
Site 90
T572
P
G
T
G
E
W
H
T
F
N
D
S
S
V
T
Site 91
S576
E
W
H
T
F
N
D
S
S
V
T
P
M
S
S
Site 92
S577
W
H
T
F
N
D
S
S
V
T
P
M
S
S
S
Site 93
T579
T
F
N
D
S
S
V
T
P
M
S
S
S
Q
V
Site 94
S582
D
S
S
V
T
P
M
S
S
S
Q
V
R
T
S
Site 95
S583
S
S
V
T
P
M
S
S
S
Q
V
R
T
S
D
Site 96
S584
S
V
T
P
M
S
S
S
Q
V
R
T
S
D
A
Site 97
T588
M
S
S
S
Q
V
R
T
S
D
A
Y
L
L
F
Site 98
S589
S
S
S
Q
V
R
T
S
D
A
Y
L
L
F
Y
Site 99
Y596
S
D
A
Y
L
L
F
Y
E
L
A
S
P
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation