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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SNRNP200
Full Name:
U5 small nuclear ribonucleoprotein 200 kDa helicase
Alias:
BRR2 homologue; U5 snRNP-specific 200 kDa protein; U5-200KD
Type:
Helicase; EC 3.6.1.-; RNA processing; RNA binding protein
Mass (Da):
244508
Number AA:
2136
UniProt ID:
O75643
International Prot ID:
IPI00420014
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005682
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0000354
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
V
T
A
R
S
L
Q
Y
E
Y
K
A
N
S
N
Site 2
Y13
A
R
S
L
Q
Y
E
Y
K
A
N
S
N
L
V
Site 3
S26
L
V
L
Q
A
D
R
S
L
I
D
R
T
R
R
Site 4
T31
D
R
S
L
I
D
R
T
R
R
D
E
P
T
G
Site 5
T37
R
T
R
R
D
E
P
T
G
E
V
L
S
L
V
Site 6
S42
E
P
T
G
E
V
L
S
L
V
G
K
L
E
G
Site 7
Y87
D
I
N
K
M
K
G
Y
T
L
L
S
E
G
I
Site 8
Y102
D
E
M
V
G
I
I
Y
K
P
K
T
K
E
T
Site 9
T106
G
I
I
Y
K
P
K
T
K
E
T
R
E
T
Y
Site 10
T112
K
T
K
E
T
R
E
T
Y
E
V
L
L
S
F
Site 11
Y113
T
K
E
T
R
E
T
Y
E
V
L
L
S
F
I
Site 12
T167
L
L
G
Q
T
D
D
T
R
Y
H
V
L
V
N
Site 13
Y169
G
Q
T
D
D
T
R
Y
H
V
L
V
N
L
G
Site 14
Y182
L
G
K
K
I
T
D
Y
G
G
D
K
E
I
Q
Site 15
Y199
D
D
N
I
D
E
T
Y
G
V
N
V
Q
F
E
Site 16
S207
G
V
N
V
Q
F
E
S
D
E
E
E
G
D
E
Site 17
Y217
E
E
G
D
E
D
V
Y
G
E
V
R
E
E
A
Site 18
S225
G
E
V
R
E
E
A
S
D
D
D
M
E
G
D
Site 19
S253
A
S
G
E
L
M
S
S
K
K
K
D
L
H
P
Site 20
Y276
Q
R
Q
L
S
R
F
Y
D
D
A
I
V
S
Q
Site 21
T295
E
V
L
E
I
L
K
T
A
S
D
D
R
E
C
Site 22
S297
L
E
I
L
K
T
A
S
D
D
R
E
C
E
N
Site 23
Y361
P
E
L
S
K
F
L
Y
Q
L
H
E
T
E
K
Site 24
S377
D
L
I
R
E
E
R
S
R
R
E
R
V
R
Q
Site 25
S385
R
R
E
R
V
R
Q
S
R
M
D
T
D
L
E
Site 26
T389
V
R
Q
S
R
M
D
T
D
L
E
T
M
D
L
Site 27
T393
R
M
D
T
D
L
E
T
M
D
L
D
Q
G
G
Site 28
S434
R
C
Q
L
P
D
G
S
F
R
R
Q
R
K
G
Site 29
Y442
F
R
R
Q
R
K
G
Y
E
E
V
H
V
P
A
Site 30
Y470
P
V
E
K
L
P
K
Y
A
Q
A
G
F
E
G
Site 31
T480
A
G
F
E
G
F
K
T
L
N
R
I
Q
S
K
Site 32
S486
K
T
L
N
R
I
Q
S
K
L
Y
R
A
A
L
Site 33
Y540
V
D
D
F
K
I
I
Y
I
A
P
M
R
S
L
Site 34
T597
P
E
K
W
D
I
I
T
R
K
G
G
E
R
T
Site 35
Y605
R
K
G
G
E
R
T
Y
T
Q
L
V
R
L
I
Site 36
T606
K
G
G
E
R
T
Y
T
Q
L
V
R
L
I
I
Site 37
T642
A
I
R
N
I
E
M
T
Q
E
D
V
R
L
I
Site 38
T663
P
N
Y
E
D
V
A
T
F
L
R
V
D
P
A
Site 39
Y675
D
P
A
K
G
L
F
Y
F
D
N
S
F
R
P
Site 40
S679
G
L
F
Y
F
D
N
S
F
R
P
V
P
L
E
Site 41
Y689
P
V
P
L
E
Q
T
Y
V
G
I
T
E
K
K
Site 42
Y709
Q
I
M
N
E
I
V
Y
E
K
I
M
E
H
A
Site 43
T731
F
V
H
S
R
K
E
T
G
K
T
A
R
A
I
Site 44
T734
S
R
K
E
T
G
K
T
A
R
A
I
R
D
M
Site 45
T747
D
M
C
L
E
K
D
T
L
G
L
F
L
R
E
Site 46
S756
G
L
F
L
R
E
G
S
A
S
T
E
V
L
R
Site 47
S758
F
L
R
E
G
S
A
S
T
E
V
L
R
T
E
Site 48
T764
A
S
T
E
V
L
R
T
E
A
E
Q
C
K
N
Site 49
T831
H
T
V
I
I
K
G
T
Q
V
Y
S
P
E
K
Site 50
S835
I
K
G
T
Q
V
Y
S
P
E
K
G
R
W
T
Site 51
T842
S
P
E
K
G
R
W
T
E
L
G
A
L
D
I
Site 52
Y861
G
R
A
G
R
P
Q
Y
D
T
K
G
E
G
I
Site 53
T863
A
G
R
P
Q
Y
D
T
K
G
E
G
I
L
I
Site 54
T871
K
G
E
G
I
L
I
T
S
H
G
E
L
Q
Y
Site 55
S872
G
E
G
I
L
I
T
S
H
G
E
L
Q
Y
Y
Site 56
Y878
T
S
H
G
E
L
Q
Y
Y
L
S
L
L
N
Q
Site 57
Y879
S
H
G
E
L
Q
Y
Y
L
S
L
L
N
Q
Q
Site 58
S881
G
E
L
Q
Y
Y
L
S
L
L
N
Q
Q
L
P
Site 59
S891
N
Q
Q
L
P
I
E
S
Q
M
V
S
K
L
P
Site 60
S895
P
I
E
S
Q
M
V
S
K
L
P
D
M
L
N
Site 61
Y922
D
A
V
N
W
L
G
Y
A
Y
L
Y
I
R
M
Site 62
Y924
V
N
W
L
G
Y
A
Y
L
Y
I
R
M
L
R
Site 63
Y926
W
L
G
Y
A
Y
L
Y
I
R
M
L
R
S
P
Site 64
S932
L
Y
I
R
M
L
R
S
P
T
L
Y
G
I
S
Site 65
T934
I
R
M
L
R
S
P
T
L
Y
G
I
S
H
D
Site 66
Y936
M
L
R
S
P
T
L
Y
G
I
S
H
D
D
L
Site 67
Y972
D
K
N
N
L
V
K
Y
D
K
K
T
G
N
F
Site 68
T976
L
V
K
Y
D
K
K
T
G
N
F
Q
V
T
E
Site 69
S989
T
E
L
G
R
I
A
S
H
Y
Y
I
T
N
D
Site 70
Y991
L
G
R
I
A
S
H
Y
Y
I
T
N
D
T
V
Site 71
T1028
S
S
E
F
K
N
I
T
V
R
E
E
E
K
L
Site 72
S1056
K
E
S
I
E
E
P
S
A
K
I
N
V
L
L
Site 73
S1125
I
D
K
R
M
W
Q
S
M
C
P
L
R
Q
F
Site 74
Y1154
N
F
P
F
E
R
L
Y
D
L
N
H
N
E
I
Site 75
T1173
R
M
P
K
M
G
K
T
I
H
K
Y
V
H
L
Site 76
Y1177
M
G
K
T
I
H
K
Y
V
H
L
F
P
K
L
Site 77
T1203
S
T
L
K
V
E
L
T
I
T
P
D
F
Q
W
Site 78
T1205
L
K
V
E
L
T
I
T
P
D
F
Q
W
D
E
Site 79
Y1245
Y
F
L
L
K
A
K
Y
A
Q
D
E
H
L
I
Site 80
Y1266
F
E
P
L
P
P
Q
Y
F
I
R
V
V
S
D
Site 81
T1280
D
R
W
L
S
C
E
T
Q
L
P
V
S
F
R
Site 82
Y1295
H
L
I
L
P
E
K
Y
P
P
P
T
E
L
L
Site 83
S1315
P
V
S
A
L
R
N
S
A
F
E
S
L
Y
Q
Site 84
S1319
L
R
N
S
A
F
E
S
L
Y
Q
D
K
F
P
Site 85
Y1321
N
S
A
F
E
S
L
Y
Q
D
K
F
P
F
F
Site 86
T1338
I
Q
T
Q
V
F
N
T
V
Y
N
S
D
D
N
Site 87
Y1340
T
Q
V
F
N
T
V
Y
N
S
D
D
N
V
F
Site 88
T1352
N
V
F
V
G
A
P
T
G
S
G
K
T
I
C
Site 89
S1354
F
V
G
A
P
T
G
S
G
K
T
I
C
A
E
Site 90
Y1378
S
S
E
G
R
C
V
Y
I
T
P
M
E
A
L
Site 91
Y1390
E
A
L
A
E
Q
V
Y
M
D
W
Y
E
K
F
Site 92
Y1394
E
Q
V
Y
M
D
W
Y
E
K
F
Q
D
R
L
Site 93
T1409
N
K
K
V
V
L
L
T
G
E
T
S
T
D
L
Site 94
S1427
G
K
G
N
I
I
I
S
T
P
E
K
W
D
I
Site 95
T1428
K
G
N
I
I
I
S
T
P
E
K
W
D
I
L
Site 96
S1436
P
E
K
W
D
I
L
S
R
R
W
K
Q
R
K
Site 97
Y1476
V
I
C
S
R
M
R
Y
I
S
S
Q
I
E
R
Site 98
S1478
C
S
R
M
R
Y
I
S
S
Q
I
E
R
P
I
Site 99
S1479
S
R
M
R
Y
I
S
S
Q
I
E
R
P
I
R
Site 100
T1535
Q
G
F
N
I
S
H
T
Q
T
R
L
L
S
M
Site 101
T1537
F
N
I
S
H
T
Q
T
R
L
L
S
M
A
K
Site 102
S1541
H
T
Q
T
R
L
L
S
M
A
K
P
V
Y
H
Site 103
Y1547
L
S
M
A
K
P
V
Y
H
A
I
T
K
H
S
Site 104
S1554
Y
H
A
I
T
K
H
S
P
K
K
P
V
I
V
Site 105
T1569
F
V
P
S
R
K
Q
T
R
L
T
A
I
D
I
Site 106
T1572
S
R
K
Q
T
R
L
T
A
I
D
I
L
T
T
Site 107
T1593
R
Q
R
F
L
H
C
T
E
K
D
L
I
P
Y
Site 108
Y1600
T
E
K
D
L
I
P
Y
L
E
K
L
S
D
S
Site 109
S1605
I
P
Y
L
E
K
L
S
D
S
T
L
K
E
T
Site 110
T1608
L
E
K
L
S
D
S
T
L
K
E
T
L
L
N
Site 111
S1625
G
Y
L
H
E
G
L
S
P
M
E
R
R
L
V
Site 112
Y1668
V
I
I
M
D
T
Q
Y
Y
N
G
K
I
H
A
Site 113
Y1669
I
I
M
D
T
Q
Y
Y
N
G
K
I
H
A
Y
Site 114
Y1676
Y
N
G
K
I
H
A
Y
V
D
Y
P
I
Y
D
Site 115
Y1679
K
I
H
A
Y
V
D
Y
P
I
Y
D
V
L
Q
Site 116
Y1682
A
Y
V
D
Y
P
I
Y
D
V
L
Q
M
V
G
Site 117
Y1719
D
F
F
K
K
F
L
Y
E
P
L
P
V
E
S
Site 118
Y1754
N
K
Q
D
A
V
D
Y
L
T
W
T
F
L
Y
Site 119
T1756
Q
D
A
V
D
Y
L
T
W
T
F
L
Y
R
R
Site 120
Y1761
Y
L
T
W
T
F
L
Y
R
R
M
T
Q
N
P
Site 121
Y1770
R
M
T
Q
N
P
N
Y
Y
N
L
Q
G
I
S
Site 122
Y1771
M
T
Q
N
P
N
Y
Y
N
L
Q
G
I
S
H
Site 123
S1782
G
I
S
H
R
H
L
S
D
H
L
S
E
L
V
Site 124
S1786
R
H
L
S
D
H
L
S
E
L
V
E
Q
T
L
Site 125
S1794
E
L
V
E
Q
T
L
S
D
L
E
Q
S
K
C
Site 126
S1799
T
L
S
D
L
E
Q
S
K
C
I
S
I
E
D
Site 127
S1803
L
E
Q
S
K
C
I
S
I
E
D
E
M
D
V
Site 128
T1840
S
M
S
L
N
A
K
T
K
V
R
G
L
I
E
Site 129
S1850
R
G
L
I
E
I
I
S
N
A
A
E
Y
E
N
Site 130
T1891
F
N
D
P
H
V
K
T
N
L
L
L
Q
A
H
Site 131
S1900
L
L
L
Q
A
H
L
S
R
M
Q
L
S
A
E
Site 132
S1905
H
L
S
R
M
Q
L
S
A
E
L
Q
S
D
T
Site 133
T1912
S
A
E
L
Q
S
D
T
E
E
I
L
S
K
A
Site 134
S1917
S
D
T
E
E
I
L
S
K
A
I
R
L
I
Q
Site 135
S1931
Q
A
C
V
D
V
L
S
S
N
G
W
L
S
P
Site 136
S1937
L
S
S
N
G
W
L
S
P
A
L
A
A
M
E
Site 137
S1955
M
V
T
Q
A
M
W
S
K
D
S
Y
L
K
Q
Site 138
S1958
Q
A
M
W
S
K
D
S
Y
L
K
Q
L
P
H
Site 139
Y1959
A
M
W
S
K
D
S
Y
L
K
Q
L
P
H
F
Site 140
T1975
S
E
H
I
K
R
C
T
D
K
G
V
E
S
V
Site 141
S2002
A
L
L
Q
L
T
D
S
Q
I
A
D
V
A
R
Site 142
Y2014
V
A
R
F
C
N
R
Y
P
N
I
E
L
S
Y
Site 143
S2020
R
Y
P
N
I
E
L
S
Y
E
V
V
D
K
D
Site 144
Y2021
Y
P
N
I
E
L
S
Y
E
V
V
D
K
D
S
Site 145
S2028
Y
E
V
V
D
K
D
S
I
R
S
G
G
P
V
Site 146
T2048
L
E
R
E
E
E
V
T
G
P
V
I
A
P
L
Site 147
S2075
I
G
D
A
K
S
N
S
L
I
S
I
K
R
L
Site 148
S2078
A
K
S
N
S
L
I
S
I
K
R
L
T
L
Q
Site 149
Y2104
P
A
T
G
A
H
N
Y
T
L
Y
F
M
S
D
Site 150
T2105
A
T
G
A
H
N
Y
T
L
Y
F
M
S
D
A
Site 151
Y2107
G
A
H
N
Y
T
L
Y
F
M
S
D
A
Y
M
Site 152
Y2113
L
Y
F
M
S
D
A
Y
M
G
C
D
Q
E
Y
Site 153
Y2120
Y
M
G
C
D
Q
E
Y
K
F
S
V
D
V
K
Site 154
S2123
C
D
Q
E
Y
K
F
S
V
D
V
K
E
A
E
Site 155
T2131
V
D
V
K
E
A
E
T
D
S
D
S
D
_
_
Site 156
S2133
V
K
E
A
E
T
D
S
D
S
D
_
_
_
_
Site 157
S2135
E
A
E
T
D
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation