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Updated November 2019
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Protein Info
Short Name:
UTP20
Full Name:
Small subunit processome component 20 homolog
Alias:
Down regulated in metastasis; Down-regulated in metastasis protein; UTP20, small subunit (SSU) processome component
Type:
Mass (Da):
318400
Number AA:
2785
UniProt ID:
O75691
International Prot ID:
IPI00004970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005732
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0030515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
T
K
P
V
S
H
K
T
E
N
T
Y
R
F
L
Site 2
T13
V
S
H
K
T
E
N
T
Y
R
F
L
T
F
A
Site 3
T18
E
N
T
Y
R
F
L
T
F
A
E
R
L
G
N
Site 4
T37
I
I
H
R
I
D
R
T
A
S
Y
E
E
E
V
Site 5
S39
H
R
I
D
R
T
A
S
Y
E
E
E
V
E
T
Site 6
Y40
R
I
D
R
T
A
S
Y
E
E
E
V
E
T
Y
Site 7
T46
S
Y
E
E
E
V
E
T
Y
F
F
E
G
L
L
Site 8
Y47
Y
E
E
E
V
E
T
Y
F
F
E
G
L
L
K
Site 9
T61
K
W
R
E
L
N
L
T
E
H
F
G
K
F
Y
Site 10
Y68
T
E
H
F
G
K
F
Y
K
E
V
I
D
K
C
Site 11
S91
H
Q
N
E
I
V
Q
S
L
K
T
H
L
Q
V
Site 12
S101
T
H
L
Q
V
K
N
S
F
A
Y
Q
P
L
L
Site 13
Y123
R
D
L
Q
M
D
F
Y
P
H
F
P
E
F
F
Site 14
T139
T
I
T
S
I
L
E
T
Q
D
T
E
L
L
E
Site 15
T142
S
I
L
E
T
Q
D
T
E
L
L
E
W
A
F
Site 16
S168
R
L
M
V
K
D
M
S
S
I
Y
S
M
Y
S
Site 17
S169
L
M
V
K
D
M
S
S
I
Y
S
M
Y
S
T
Site 18
S172
K
D
M
S
S
I
Y
S
M
Y
S
T
L
L
A
Site 19
S175
S
S
I
Y
S
M
Y
S
T
L
L
A
H
K
K
Site 20
T176
S
I
Y
S
M
Y
S
T
L
L
A
H
K
K
L
Site 21
S192
I
R
N
F
A
A
E
S
F
T
F
L
M
R
K
Site 22
S201
T
F
L
M
R
K
V
S
D
K
N
A
L
F
N
Site 23
S279
T
L
K
N
M
V
K
S
T
V
S
Y
I
S
K
Site 24
T280
L
K
N
M
V
K
S
T
V
S
Y
I
S
K
E
Site 25
S282
N
M
V
K
S
T
V
S
Y
I
S
K
E
H
F
Site 26
Y283
M
V
K
S
T
V
S
Y
I
S
K
E
H
F
G
Site 27
S285
K
S
T
V
S
Y
I
S
K
E
H
F
G
T
F
Site 28
T291
I
S
K
E
H
F
G
T
F
F
E
C
L
Q
E
Site 29
S299
F
F
E
C
L
Q
E
S
L
L
D
L
H
T
K
Site 30
T305
E
S
L
L
D
L
H
T
K
V
T
K
T
N
C
Site 31
T310
L
H
T
K
V
T
K
T
N
C
C
E
S
S
E
Site 32
S316
K
T
N
C
C
E
S
S
E
Q
I
K
R
L
L
Site 33
T336
L
V
K
H
G
S
G
T
K
I
P
T
P
A
D
Site 34
T340
G
S
G
T
K
I
P
T
P
A
D
V
C
K
V
Site 35
S356
S
Q
T
L
Q
V
A
S
L
S
T
S
C
W
E
Site 36
T383
E
N
V
S
L
P
E
T
L
I
K
E
T
I
E
Site 37
Y467
G
S
M
A
I
E
K
Y
P
L
V
F
S
P
Q
Site 38
S487
I
K
Q
K
K
T
R
S
K
G
R
N
E
Q
F
Site 39
T512
K
L
P
P
N
K
D
T
T
Y
L
S
Q
S
W
Site 40
T513
L
P
P
N
K
D
T
T
Y
L
S
Q
S
W
A
Site 41
Y514
P
P
N
K
D
T
T
Y
L
S
Q
S
W
A
A
Site 42
S516
N
K
D
T
T
Y
L
S
Q
S
W
A
A
L
V
Site 43
S555
F
M
T
V
D
K
G
S
F
G
K
G
N
L
F
Site 44
S573
Q
A
V
N
T
L
L
S
L
E
E
S
S
E
L
Site 45
S639
P
K
L
Q
A
N
I
S
T
G
V
S
K
I
R
Site 46
S663
F
D
V
Q
L
P
E
S
M
E
D
D
G
L
S
Site 47
S670
S
M
E
D
D
G
L
S
E
R
Q
S
V
F
A
Site 48
S674
D
G
L
S
E
R
Q
S
V
F
A
I
L
R
Q
Site 49
Y692
V
P
A
T
V
N
D
Y
R
E
K
L
L
H
L
Site 50
T709
L
R
H
D
V
V
Q
T
A
V
P
D
G
P
L
Site 51
S745
P
V
I
E
L
I
S
S
H
A
H
E
M
E
N
Site 52
Y759
N
K
Q
F
W
K
V
Y
Y
E
H
L
E
K
A
Site 53
T768
E
H
L
E
K
A
A
T
H
A
E
K
E
L
Q
Site 54
T779
K
E
L
Q
N
D
M
T
D
E
K
S
V
G
D
Site 55
S783
N
D
M
T
D
E
K
S
V
G
D
E
S
W
E
Site 56
S788
E
K
S
V
G
D
E
S
W
E
Q
T
Q
E
G
Site 57
T792
G
D
E
S
W
E
Q
T
Q
E
G
D
V
G
A
Site 58
Y801
E
G
D
V
G
A
L
Y
H
E
Q
L
A
L
K
Site 59
T829
F
L
L
W
R
A
L
T
K
F
P
E
R
V
E
Site 60
S839
P
E
R
V
E
P
R
S
R
E
L
S
P
L
F
Site 61
S843
E
P
R
S
R
E
L
S
P
L
F
L
R
F
I
Site 62
Y855
R
F
I
N
N
E
Y
Y
P
A
D
L
Q
V
A
Site 63
S902
A
V
P
Q
D
E
S
S
Q
K
K
K
T
R
R
Site 64
T907
E
S
S
Q
K
K
K
T
R
R
A
A
A
K
Q
Site 65
Y932
F
S
N
P
R
A
L
Y
L
E
S
K
L
Y
E
Site 66
Y941
E
S
K
L
Y
E
L
Y
L
Q
L
L
L
H
Q
Site 67
S983
Q
R
L
L
E
D
R
S
F
K
E
E
I
V
H
Site 68
Y1017
P
I
L
M
R
I
L
Y
G
R
M
K
N
K
T
Site 69
T1024
Y
G
R
M
K
N
K
T
G
S
K
T
Q
G
K
Site 70
S1026
R
M
K
N
K
T
G
S
K
T
Q
G
K
S
A
Site 71
T1028
K
N
K
T
G
S
K
T
Q
G
K
S
A
S
G
Site 72
S1032
G
S
K
T
Q
G
K
S
A
S
G
T
R
M
A
Site 73
S1034
K
T
Q
G
K
S
A
S
G
T
R
M
A
I
V
Site 74
T1036
Q
G
K
S
A
S
G
T
R
M
A
I
V
L
R
Site 75
S1100
R
Q
H
G
I
L
N
S
L
E
I
V
L
K
N
Site 76
S1131
L
C
M
T
A
T
V
S
H
I
L
D
Q
R
E
Site 77
Y1169
I
F
L
D
W
E
S
Y
Q
F
R
T
E
E
I
Site 78
S1189
G
A
V
W
P
Q
I
S
R
L
G
S
E
S
Q
Site 79
S1193
P
Q
I
S
R
L
G
S
E
S
Q
Y
S
P
T
Site 80
S1195
I
S
R
L
G
S
E
S
Q
Y
S
P
T
P
L
Site 81
Y1197
R
L
G
S
E
S
Q
Y
S
P
T
P
L
L
K
Site 82
S1198
L
G
S
E
S
Q
Y
S
P
T
P
L
L
K
L
Site 83
T1200
S
E
S
Q
Y
S
P
T
P
L
L
K
L
I
S
Site 84
S1207
T
P
L
L
K
L
I
S
I
W
S
R
N
A
R
Site 85
Y1215
I
W
S
R
N
A
R
Y
F
P
L
L
A
K
Q
Site 86
S1337
S
K
E
L
G
I
L
S
K
I
S
K
F
M
K
Site 87
S1340
L
G
I
L
S
K
I
S
K
F
M
K
D
K
E
Site 88
T1369
R
G
N
I
A
E
D
T
E
V
D
I
L
V
T
Site 89
S1389
K
H
C
V
D
P
T
S
F
L
K
P
I
A
K
Site 90
S1418
C
T
V
F
E
T
L
S
D
F
E
S
G
L
K
Site 91
S1422
E
T
L
S
D
F
E
S
G
L
K
Y
I
T
D
Site 92
T1428
E
S
G
L
K
Y
I
T
D
V
V
K
L
N
A
Site 93
T1452
N
F
D
V
R
F
E
T
F
Q
T
I
T
S
Y
Site 94
T1455
V
R
F
E
T
F
Q
T
I
T
S
Y
I
K
E
Site 95
S1488
N
L
E
L
G
D
M
S
L
S
D
N
A
S
M
Site 96
S1490
E
L
G
D
M
S
L
S
D
N
A
S
M
C
L
Site 97
Y1514
L
N
V
T
E
K
D
Y
R
E
I
I
H
R
S
Site 98
S1521
Y
R
E
I
I
H
R
S
L
L
E
K
L
R
K
Site 99
S1532
K
L
R
K
G
L
K
S
Q
T
E
S
I
Q
Q
Site 100
T1534
R
K
G
L
K
S
Q
T
E
S
I
Q
Q
D
Y
Site 101
S1536
G
L
K
S
Q
T
E
S
I
Q
Q
D
Y
T
T
Site 102
Y1541
T
E
S
I
Q
Q
D
Y
T
T
I
L
S
C
L
Site 103
Y1567
D
L
V
Q
L
T
H
Y
H
D
P
E
M
D
F
Site 104
S1605
M
E
G
K
V
V
L
S
S
K
S
L
Q
N
Y
Site 105
S1608
K
V
V
L
S
S
K
S
L
Q
N
Y
I
M
P
Site 106
Y1612
S
S
K
S
L
Q
N
Y
I
M
P
Y
A
M
T
Site 107
Y1652
K
H
L
S
W
S
A
Y
M
Y
Y
L
K
H
F
Site 108
T1690
A
F
H
F
D
H
K
T
L
E
E
Q
M
G
K
Site 109
Y1728
V
D
E
E
E
K
E
Y
T
C
K
S
L
S
D
Site 110
T1729
D
E
E
E
K
E
Y
T
C
K
S
L
S
D
N
Site 111
S1732
E
K
E
Y
T
C
K
S
L
S
D
N
G
Q
P
Site 112
S1734
E
Y
T
C
K
S
L
S
D
N
G
Q
P
G
T
Site 113
T1741
S
D
N
G
Q
P
G
T
P
D
P
A
D
S
G
Site 114
S1747
G
T
P
D
P
A
D
S
G
G
T
S
A
K
E
Site 115
S1751
P
A
D
S
G
G
T
S
A
K
E
S
E
C
I
Site 116
S1755
G
G
T
S
A
K
E
S
E
C
I
T
K
P
V
Site 117
T1759
A
K
E
S
E
C
I
T
K
P
V
S
F
L
P
Site 118
S1763
E
C
I
T
K
P
V
S
F
L
P
Q
N
K
E
Site 119
T1775
N
K
E
E
I
E
R
T
I
K
N
I
Q
G
T
Site 120
T1782
T
I
K
N
I
Q
G
T
I
T
G
D
I
L
P
Site 121
T1784
K
N
I
Q
G
T
I
T
G
D
I
L
P
R
L
Site 122
T1799
H
K
C
L
A
S
T
T
K
R
E
E
E
H
K
Site 123
S1810
E
E
H
K
L
V
K
S
K
V
V
N
D
E
E
Site 124
S1867
E
I
R
D
I
A
R
S
T
L
A
K
I
I
E
Site 125
T1868
I
R
D
I
A
R
S
T
L
A
K
I
I
E
D
Site 126
S1959
K
V
M
E
A
R
R
S
K
S
Y
D
S
Y
E
Site 127
S1961
M
E
A
R
R
S
K
S
Y
D
S
Y
E
I
L
Site 128
Y1962
E
A
R
R
S
K
S
Y
D
S
Y
E
I
L
G
Site 129
S1964
R
R
S
K
S
Y
D
S
Y
E
I
L
G
K
F
Site 130
Y1965
R
S
K
S
Y
D
S
Y
E
I
L
G
K
F
V
Site 131
T1992
K
E
I
L
Q
N
T
T
S
L
K
L
A
R
K
Site 132
S1993
E
I
L
Q
N
T
T
S
L
K
L
A
R
K
V
Site 133
T2003
L
A
R
K
V
H
E
T
L
R
R
I
T
V
G
Site 134
T2008
H
E
T
L
R
R
I
T
V
G
L
I
V
N
Q
Site 135
S2021
N
Q
E
M
T
A
E
S
I
L
L
L
S
Y
G
Site 136
T2038
S
E
N
L
P
L
L
T
E
K
E
K
N
P
V
Site 137
S2057
D
P
R
L
P
P
Q
S
C
L
L
L
P
P
T
Site 138
T2064
S
C
L
L
L
P
P
T
P
V
R
G
G
Q
K
Site 139
S2075
G
G
Q
K
A
V
V
S
R
K
T
N
M
H
I
Site 140
T2078
K
A
V
V
S
R
K
T
N
M
H
I
F
I
E
Site 141
S2094
G
L
R
L
L
H
L
S
L
K
T
S
K
I
K
Site 142
S2098
L
H
L
S
L
K
T
S
K
I
K
S
S
G
E
Site 143
S2102
L
K
T
S
K
I
K
S
S
G
E
C
V
L
E
Site 144
S2147
V
L
R
F
P
L
P
S
I
E
T
K
A
E
Q
Site 145
T2156
E
T
K
A
E
Q
L
T
K
H
L
F
L
L
L
Site 146
S2196
I
L
V
K
K
V
K
S
Y
Q
I
T
E
K
Q
Site 147
T2200
K
V
K
S
Y
Q
I
T
E
K
Q
L
Q
V
L
Site 148
Y2216
A
Y
A
E
E
D
I
Y
D
T
S
R
Q
A
T
Site 149
T2218
A
E
E
D
I
Y
D
T
S
R
Q
A
T
A
F
Site 150
T2223
Y
D
T
S
R
Q
A
T
A
F
G
L
L
K
A
Site 151
S2249
D
E
V
M
R
K
V
S
K
L
A
V
S
A
Q
Site 152
S2257
K
L
A
V
S
A
Q
S
E
P
A
R
V
Q
C
Site 153
Y2275
F
L
K
Y
I
L
D
Y
P
L
G
D
K
L
R
Site 154
Y2294
F
M
L
A
Q
L
N
Y
E
H
E
T
G
R
E
Site 155
S2302
E
H
E
T
G
R
E
S
T
L
E
M
I
A
Y
Site 156
T2303
H
E
T
G
R
E
S
T
L
E
M
I
A
Y
L
Site 157
T2341
T
I
N
D
D
S
A
T
C
K
K
M
A
S
M
Site 158
S2347
A
T
C
K
K
M
A
S
M
T
I
K
S
L
L
Site 159
T2349
C
K
K
M
A
S
M
T
I
K
S
L
L
G
K
Site 160
S2358
K
S
L
L
G
K
I
S
L
E
K
K
D
W
L
Site 161
T2405
D
F
E
K
R
L
G
T
V
L
P
V
I
E
K
Site 162
T2460
Q
F
T
K
P
A
E
T
L
S
K
I
W
S
H
Site 163
S2462
T
K
P
A
E
T
L
S
K
I
W
S
H
V
H
Site 164
S2466
E
T
L
S
K
I
W
S
H
V
H
S
H
L
R
Site 165
S2531
D
L
D
Q
K
M
K
S
I
S
L
A
S
C
H
Site 166
S2533
D
Q
K
M
K
S
I
S
L
A
S
C
H
Q
L
Site 167
S2536
M
K
S
I
S
L
A
S
C
H
Q
L
H
S
K
Site 168
S2542
A
S
C
H
Q
L
H
S
K
F
L
D
Q
S
L
Site 169
S2548
H
S
K
F
L
D
Q
S
L
G
E
Q
V
V
K
Site 170
Y2570
V
L
Y
L
L
E
L
Y
C
E
D
K
Q
S
K
Site 171
S2576
L
Y
C
E
D
K
Q
S
K
I
K
E
D
L
E
Site 172
S2601
C
A
D
E
K
A
E
S
D
G
E
E
K
E
E
Site 173
T2618
E
E
L
G
R
P
A
T
L
L
W
L
I
Q
K
Site 174
Y2636
I
A
K
L
E
A
A
Y
S
P
R
N
P
L
K
Site 175
S2637
A
K
L
E
A
A
Y
S
P
R
N
P
L
K
R
Site 176
T2681
L
F
R
E
L
N
S
T
Y
S
E
Q
D
P
L
Site 177
S2683
R
E
L
N
S
T
Y
S
E
Q
D
P
L
L
K
Site 178
S2715
S
F
S
L
A
F
A
S
V
Q
K
Q
A
N
E
Site 179
S2754
M
K
K
H
K
N
K
S
E
A
K
K
R
K
I
Site 180
Y2768
I
E
F
L
R
P
G
Y
K
A
K
R
Q
K
S
Site 181
S2775
Y
K
A
K
R
Q
K
S
H
S
L
K
D
L
A
Site 182
S2777
A
K
R
Q
K
S
H
S
L
K
D
L
A
M
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation