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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3C2G
Full Name:
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
Alias:
P3C2G; Phosphoinositide 3-Kinase-C2-gamma; Phosphoinositide-3-kinase, class 2, gamma polypeptide; PI3K-C2gamma; PtdIns-3-kinase C2 gamma
Type:
EC 2.7.1.154; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate
Mass (Da):
165650
Number AA:
1444
UniProt ID:
O75747
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0016303
GO:0005524
GO:0035005
PhosphoSite+
KinaseNET
Biological Process:
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
F
V
N
Q
P
H
S
S
S
Q
V
S
L
G
Site 2
S33
F
V
N
Q
P
H
S
S
S
Q
V
S
L
G
F
Site 3
S34
V
N
Q
P
H
S
S
S
Q
V
S
L
G
F
D
Site 4
S37
P
H
S
S
S
Q
V
S
L
G
F
D
Q
I
V
Site 5
S48
D
Q
I
V
D
E
I
S
G
K
I
P
H
Y
E
Site 6
Y54
I
S
G
K
I
P
H
Y
E
S
E
I
D
E
N
Site 7
S56
G
K
I
P
H
Y
E
S
E
I
D
E
N
T
F
Site 8
T62
E
S
E
I
D
E
N
T
F
F
V
P
T
A
P
Site 9
S73
P
T
A
P
K
W
D
S
T
G
H
S
L
N
E
Site 10
S77
K
W
D
S
T
G
H
S
L
N
E
A
H
Q
I
Site 11
S85
L
N
E
A
H
Q
I
S
L
N
E
F
T
S
K
Site 12
S91
I
S
L
N
E
F
T
S
K
S
R
E
L
S
W
Site 13
S93
L
N
E
F
T
S
K
S
R
E
L
S
W
H
Q
Site 14
S97
T
S
K
S
R
E
L
S
W
H
Q
V
S
K
A
Site 15
S112
P
A
I
G
F
S
P
S
V
L
P
K
P
Q
N
Site 16
S128
N
K
E
C
S
W
G
S
P
I
G
K
H
H
G
Site 17
S139
K
H
H
G
A
D
D
S
R
F
S
I
L
A
P
Site 18
S142
G
A
D
D
S
R
F
S
I
L
A
P
S
F
T
Site 19
S180
S
S
I
P
P
T
N
S
S
F
S
S
D
F
M
Site 20
S240
Q
L
V
E
V
P
Q
S
S
N
T
S
L
A
S
Site 21
T274
N
S
G
K
I
W
S
T
T
T
A
F
P
Y
Q
Site 22
S470
K
G
E
N
F
Y
Q
S
S
E
T
S
A
K
G
Site 23
T483
K
G
L
I
E
K
V
T
T
E
L
S
T
S
I
Site 24
S959
M
I
I
Y
R
C
L
S
T
G
K
D
Q
R
L
Site 25
S1213
E
R
A
I
L
G
F
S
K
K
S
S
N
L
Y
Site 26
Y1220
S
K
K
S
S
N
L
Y
L
I
Q
V
T
H
S
Site 27
S1232
T
H
S
N
N
E
T
S
L
T
E
K
S
F
E
Site 28
T1234
S
N
N
E
T
S
L
T
E
K
S
F
E
Q
F
Site 29
S1237
E
T
S
L
T
E
K
S
F
E
Q
F
S
K
L
Site 30
S1242
E
K
S
F
E
Q
F
S
K
L
H
S
Q
L
Q
Site 31
S1246
E
Q
F
S
K
L
H
S
Q
L
Q
K
Q
F
A
Site 32
S1254
Q
L
Q
K
Q
F
A
S
L
T
L
P
E
F
P
Site 33
T1256
Q
K
Q
F
A
S
L
T
L
P
E
F
P
H
W
Site 34
Y1282
R
F
R
D
L
N
H
Y
M
E
Q
I
L
N
V
Site 35
T1294
L
N
V
S
H
E
V
T
N
S
D
C
V
L
S
Site 36
T1311
L
S
E
A
V
Q
Q
T
V
E
S
S
P
V
Y
Site 37
S1315
V
Q
Q
T
V
E
S
S
P
V
Y
L
G
E
K
Site 38
Y1318
T
V
E
S
S
P
V
Y
L
G
E
K
K
F
P
Site 39
T1343
S
Y
E
D
V
K
L
T
I
L
V
K
H
M
K
Site 40
S1358
N
I
H
L
P
D
G
S
A
P
S
A
H
V
E
Site 41
S1361
L
P
D
G
S
A
P
S
A
H
V
E
F
Y
L
Site 42
Y1367
P
S
A
H
V
E
F
Y
L
L
P
Y
P
S
E
Site 43
Y1371
V
E
F
Y
L
L
P
Y
P
S
E
V
L
R
R
Site 44
S1373
F
Y
L
L
P
Y
P
S
E
V
L
R
R
K
T
Site 45
T1380
S
E
V
L
R
R
K
T
K
S
V
P
K
C
T
Site 46
S1382
V
L
R
R
K
T
K
S
V
P
K
C
T
D
P
Site 47
T1390
V
P
K
C
T
D
P
T
Y
N
E
I
V
V
Y
Site 48
Y1391
P
K
C
T
D
P
T
Y
N
E
I
V
V
Y
D
Site 49
Y1397
T
Y
N
E
I
V
V
Y
D
E
V
T
E
L
Q
Site 50
S1428
A
I
N
I
R
L
C
S
V
P
L
D
K
E
K
Site 51
Y1437
P
L
D
K
E
K
W
Y
P
L
G
N
S
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation