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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC22A3
Full Name:
Solute carrier family 22 member 3
Alias:
EMTH; Extraneuronal monoamine transporter; Organic cation transporter 3; S22A3
Type:
Membrane fraction, Membrane, Integral plasma membrane protein
Mass (Da):
61280
Number AA:
556
UniProt ID:
O75751
International Prot ID:
IPI00465437
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0015651
PhosphoSite+
KinaseNET
Biological Process:
GO:0015697
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y49
L
G
T
Q
P
D
H
Y
W
C
R
G
P
S
A
Site 2
S55
H
Y
W
C
R
G
P
S
A
A
A
L
A
E
R
Site 3
S66
L
A
E
R
C
G
W
S
P
E
E
E
W
N
R
Site 4
T74
P
E
E
E
W
N
R
T
A
P
A
S
R
G
P
Site 5
S78
W
N
R
T
A
P
A
S
R
G
P
E
P
P
E
Site 6
Y93
R
R
G
R
C
Q
R
Y
L
L
E
A
A
N
D
Site 7
S103
E
A
A
N
D
S
A
S
A
T
S
A
L
S
C
Site 8
T105
A
N
D
S
A
S
A
T
S
A
L
S
C
A
D
Site 9
Y133
P
C
R
G
G
W
R
Y
A
Q
A
H
S
T
I
Site 10
Y174
T
G
A
F
T
L
G
Y
A
A
D
R
Y
G
R
Site 11
S291
Y
Y
W
V
V
P
E
S
P
R
W
L
I
T
R
Site 12
T297
E
S
P
R
W
L
I
T
R
K
K
G
D
K
A
Site 13
Y318
I
A
K
C
N
G
K
Y
L
S
S
N
Y
S
E
Site 14
S320
K
C
N
G
K
Y
L
S
S
N
Y
S
E
I
T
Site 15
S324
K
Y
L
S
S
N
Y
S
E
I
T
V
T
D
E
Site 16
T327
S
S
N
Y
S
E
I
T
V
T
D
E
E
V
S
Site 17
T329
N
Y
S
E
I
T
V
T
D
E
E
V
S
N
P
Site 18
S337
D
E
E
V
S
N
P
S
F
L
D
L
V
R
T
Site 19
T344
S
F
L
D
L
V
R
T
P
Q
M
R
K
C
T
Site 20
Y461
Y
L
V
N
S
E
L
Y
P
T
T
L
R
N
F
Site 21
T463
V
N
S
E
L
Y
P
T
T
L
R
N
F
G
V
Site 22
T464
N
S
E
L
Y
P
T
T
L
R
N
F
G
V
S
Site 23
T528
K
G
I
A
L
P
E
T
V
D
D
V
E
K
L
Site 24
S537
D
D
V
E
K
L
G
S
P
H
S
C
K
C
G
Site 25
S540
E
K
L
G
S
P
H
S
C
K
C
G
R
N
K
Site 26
T549
K
C
G
R
N
K
K
T
P
V
S
R
S
H
L
Site 27
S552
R
N
K
K
T
P
V
S
R
S
H
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation