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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNaseH2A
Full Name:
Ribonuclease H2 subunit A
Alias:
AGS4; Aicardi-Goutieres syndrome 4 protein; JUNB; Ribonuclease H2; Ribonuclease H2, large; Ribonuclease H2, subunit A; Ribonuclease HI large; Ribonuclease HI large subunit; Ribonuclease HI subunit A; RNase H; RNase H(35); RNase H2; RNase HI large; RNASEHI; RNH2A; RNHIA; RNHL
Type:
Ribonuclease; DNA replication; EC 3.1.26.4
Mass (Da):
33395
Number AA:
299
UniProt ID:
O75792
International Prot ID:
IPI00290192
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0046872
GO:0004523
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0006401
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
S
E
L
E
R
D
N
T
G
R
C
R
L
S
S
Site 2
S17
N
T
G
R
C
R
L
S
S
P
V
P
A
V
C
Site 3
S18
T
G
R
C
R
L
S
S
P
V
P
A
V
C
R
Site 4
S68
E
A
L
K
V
A
D
S
K
T
L
L
E
S
E
Site 5
T70
L
K
V
A
D
S
K
T
L
L
E
S
E
R
E
Site 6
S74
D
S
K
T
L
L
E
S
E
R
E
R
L
F
A
Site 7
T86
L
F
A
K
M
E
D
T
D
F
V
G
W
A
L
Site 8
T103
L
S
P
N
L
I
S
T
S
M
L
G
R
V
K
Site 9
S104
S
P
N
L
I
S
T
S
M
L
G
R
V
K
Y
Site 10
Y111
S
M
L
G
R
V
K
Y
N
L
N
S
L
S
H
Site 11
S115
R
V
K
Y
N
L
N
S
L
S
H
D
T
A
T
Site 12
S117
K
Y
N
L
N
S
L
S
H
D
T
A
T
G
L
Site 13
S156
Y
Q
A
R
L
Q
Q
S
F
P
G
I
E
V
T
Site 14
Y172
K
A
K
A
D
A
L
Y
P
V
V
S
A
A
S
Site 15
T204
E
K
L
Q
D
L
D
T
D
Y
G
S
G
Y
P
Site 16
Y206
L
Q
D
L
D
T
D
Y
G
S
G
Y
P
N
D
Site 17
S208
D
L
D
T
D
Y
G
S
G
Y
P
N
D
P
K
Site 18
Y210
D
T
D
Y
G
S
G
Y
P
N
D
P
K
T
K
Site 19
T216
G
Y
P
N
D
P
K
T
K
A
W
L
K
E
H
Site 20
S237
F
P
Q
F
V
R
F
S
W
R
T
A
Q
T
I
Site 21
T240
F
V
R
F
S
W
R
T
A
Q
T
I
L
E
K
Site 22
S257
E
D
V
I
W
E
D
S
A
S
E
N
Q
E
G
Site 23
S259
V
I
W
E
D
S
A
S
E
N
Q
E
G
L
R
Site 24
T269
Q
E
G
L
R
K
I
T
S
Y
F
L
N
E
G
Site 25
S270
E
G
L
R
K
I
T
S
Y
F
L
N
E
G
S
Site 26
Y271
G
L
R
K
I
T
S
Y
F
L
N
E
G
S
Q
Site 27
S277
S
Y
F
L
N
E
G
S
Q
A
R
P
R
S
S
Site 28
S283
G
S
Q
A
R
P
R
S
S
H
R
Y
F
L
E
Site 29
S284
S
Q
A
R
P
R
S
S
H
R
Y
F
L
E
R
Site 30
Y287
R
P
R
S
S
H
R
Y
F
L
E
R
G
L
E
Site 31
T297
E
R
G
L
E
S
A
T
S
L
_
_
_
_
_
Site 32
S298
R
G
L
E
S
A
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation