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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP1R15A
Full Name:
Protein phosphatase 1 regulatory subunit 15A
Alias:
GADD34; Growth arrest and DNA damage-inducible protein GADD34; Growth arrest and DNA-damage-inducible 34; MY116; Myeloid differentiation primary response protein MyD116 homolog; Protein phosphatase 1, regulatory (inhibitor) subunit 15A
Type:
Mass (Da):
73478
Number AA:
674
UniProt ID:
O75807
International Prot ID:
IPI00290444
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007050
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
G
Q
A
P
H
Q
A
T
P
W
R
D
A
H
P
Site 2
S30
S
P
V
M
G
L
L
S
R
A
W
S
R
L
R
Site 3
S34
G
L
L
S
R
A
W
S
R
L
R
G
L
G
P
Site 4
T66
G
L
E
G
E
A
R
T
P
L
A
I
P
H
T
Site 5
T73
T
P
L
A
I
P
H
T
P
W
G
R
R
P
E
Site 6
S86
P
E
E
E
A
E
D
S
G
G
P
G
E
D
R
Site 7
T95
G
P
G
E
D
R
E
T
L
G
L
K
T
S
S
Site 8
T100
R
E
T
L
G
L
K
T
S
S
S
L
P
E
A
Site 9
S101
E
T
L
G
L
K
T
S
S
S
L
P
E
A
W
Site 10
S102
T
L
G
L
K
T
S
S
S
L
P
E
A
W
G
Site 11
Y118
L
D
D
D
D
G
M
Y
G
E
R
E
A
T
S
Site 12
T124
M
Y
G
E
R
E
A
T
S
V
P
R
G
Q
G
Site 13
S125
Y
G
E
R
E
A
T
S
V
P
R
G
Q
G
S
Site 14
S132
S
V
P
R
G
Q
G
S
Q
F
A
D
G
Q
R
Site 15
S143
D
G
Q
R
A
P
L
S
P
S
L
L
I
R
T
Site 16
S145
Q
R
A
P
L
S
P
S
L
L
I
R
T
L
Q
Site 17
T150
S
P
S
L
L
I
R
T
L
Q
G
S
D
K
N
Site 18
S154
L
I
R
T
L
Q
G
S
D
K
N
P
G
E
E
Site 19
S178
E
E
G
V
N
K
F
S
Y
P
P
S
H
R
E
Site 20
Y179
E
G
V
N
K
F
S
Y
P
P
S
H
R
E
C
Site 21
T206
V
K
K
E
A
H
R
T
S
T
S
A
L
S
P
Site 22
S207
K
K
E
A
H
R
T
S
T
S
A
L
S
P
G
Site 23
T208
K
E
A
H
R
T
S
T
S
A
L
S
P
G
S
Site 24
S209
E
A
H
R
T
S
T
S
A
L
S
P
G
S
K
Site 25
S212
R
T
S
T
S
A
L
S
P
G
S
K
P
S
T
Site 26
S215
T
S
A
L
S
P
G
S
K
P
S
T
W
V
S
Site 27
S218
L
S
P
G
S
K
P
S
T
W
V
S
C
P
G
Site 28
T219
S
P
G
S
K
P
S
T
W
V
S
C
P
G
E
Site 29
S222
S
K
P
S
T
W
V
S
C
P
G
E
E
E
N
Site 30
T232
G
E
E
E
N
Q
A
T
E
D
K
R
T
E
R
Site 31
T237
Q
A
T
E
D
K
R
T
E
R
S
K
G
A
R
Site 32
T246
R
S
K
G
A
R
K
T
S
V
S
P
R
S
S
Site 33
S247
S
K
G
A
R
K
T
S
V
S
P
R
S
S
G
Site 34
S249
G
A
R
K
T
S
V
S
P
R
S
S
G
S
D
Site 35
S252
K
T
S
V
S
P
R
S
S
G
S
D
P
R
S
Site 36
S253
T
S
V
S
P
R
S
S
G
S
D
P
R
S
W
Site 37
S255
V
S
P
R
S
S
G
S
D
P
R
S
W
E
Y
Site 38
S259
S
S
G
S
D
P
R
S
W
E
Y
R
S
G
E
Site 39
Y262
S
D
P
R
S
W
E
Y
R
S
G
E
A
S
E
Site 40
S264
P
R
S
W
E
Y
R
S
G
E
A
S
E
E
K
Site 41
S268
E
Y
R
S
G
E
A
S
E
E
K
E
E
K
A
Site 42
S290
E
A
A
P
G
P
Q
S
S
A
P
A
Q
R
P
Site 43
S291
A
A
P
G
P
Q
S
S
A
P
A
Q
R
P
Q
Site 44
S307
K
S
W
W
C
Q
P
S
D
E
E
E
G
E
V
Site 45
Y344
A
F
L
K
A
W
V
Y
W
P
G
E
D
T
E
Site 46
S362
D
E
E
E
D
E
D
S
D
S
G
S
D
E
E
Site 47
S364
E
E
D
E
D
S
D
S
G
S
D
E
E
E
G
Site 48
S366
D
E
D
S
D
S
G
S
D
E
E
E
G
E
A
Site 49
S376
E
E
G
E
A
E
A
S
S
S
T
P
A
T
G
Site 50
S377
E
G
E
A
E
A
S
S
S
T
P
A
T
G
V
Site 51
S378
G
E
A
E
A
S
S
S
T
P
A
T
G
V
F
Site 52
T382
A
S
S
S
T
P
A
T
G
V
F
L
K
S
W
Site 53
S388
A
T
G
V
F
L
K
S
W
V
Y
Q
P
G
E
Site 54
Y391
V
F
L
K
S
W
V
Y
Q
P
G
E
D
T
E
Site 55
S405
E
E
E
E
D
E
D
S
D
T
G
S
A
E
D
Site 56
T407
E
E
D
E
D
S
D
T
G
S
A
E
D
E
R
Site 57
S409
D
E
D
S
D
T
G
S
A
E
D
E
R
E
A
Site 58
S419
D
E
R
E
A
E
T
S
A
S
T
P
P
A
S
Site 59
S421
R
E
A
E
T
S
A
S
T
P
P
A
S
A
F
Site 60
T422
E
A
E
T
S
A
S
T
P
P
A
S
A
F
L
Site 61
T440
V
Y
R
P
G
E
D
T
E
E
E
E
D
E
D
Site 62
S450
E
E
D
E
D
V
D
S
E
D
K
E
D
D
S
Site 63
S457
S
E
D
K
E
D
D
S
E
A
A
L
G
E
A
Site 64
S466
A
A
L
G
E
A
E
S
D
P
H
P
S
H
P
Site 65
S471
A
E
S
D
P
H
P
S
H
P
D
Q
R
A
H
Site 66
T490
G
Y
R
P
G
K
E
T
E
E
E
E
A
A
E
Site 67
Y512
C
P
F
R
V
A
I
Y
V
P
G
E
K
P
P
Site 68
T540
R
R
L
K
R
P
E
T
P
T
H
D
P
D
P
Site 69
T542
L
K
R
P
E
T
P
T
H
D
P
D
P
E
T
Site 70
T549
T
H
D
P
D
P
E
T
P
L
K
A
R
K
V
Site 71
S559
K
A
R
K
V
R
F
S
E
K
V
T
V
H
F
Site 72
S590
E
Q
L
A
R
D
R
S
R
F
A
R
R
I
T
Site 73
T597
S
R
F
A
R
R
I
T
Q
A
Q
E
E
L
S
Site 74
S604
T
Q
A
Q
E
E
L
S
P
C
L
T
P
A
A
Site 75
T608
E
E
L
S
P
C
L
T
P
A
A
R
A
R
A
Site 76
S636
A
L
T
Q
T
L
P
S
S
S
V
P
S
S
P
Site 77
S637
L
T
Q
T
L
P
S
S
S
V
P
S
S
P
V
Site 78
S638
T
Q
T
L
P
S
S
S
V
P
S
S
P
V
Q
Site 79
S641
L
P
S
S
S
V
P
S
S
P
V
Q
T
T
P
Site 80
S642
P
S
S
S
V
P
S
S
P
V
Q
T
T
P
L
Site 81
T646
V
P
S
S
P
V
Q
T
T
P
L
S
Q
A
V
Site 82
T647
P
S
S
P
V
Q
T
T
P
L
S
Q
A
V
A
Site 83
S650
P
V
Q
T
T
P
L
S
Q
A
V
A
T
P
S
Site 84
T655
P
L
S
Q
A
V
A
T
P
S
R
S
S
A
A
Site 85
S657
S
Q
A
V
A
T
P
S
R
S
S
A
A
A
A
Site 86
S670
A
A
A
A
L
D
L
S
G
R
R
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation