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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCAR3
Full Name:
Breast cancer anti-estrogen resistance protein 3
Alias:
SH2 domain-containing protein 3B; SH2-containing protein Nsp2
Type:
Guanine nucleotide exchange factor, Ras, Adaptor/scaffold
Mass (Da):
92566
Number AA:
825
UniProt ID:
O75815
International Prot ID:
IPI00179053
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042493
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
N
H
Q
F
P
L
A
S
S
M
D
L
L
S
S
Site 2
S24
H
Q
F
P
L
A
S
S
M
D
L
L
S
S
R
Site 3
S29
A
S
S
M
D
L
L
S
S
R
S
P
L
A
E
Site 4
S30
S
S
M
D
L
L
S
S
R
S
P
L
A
E
H
Site 5
S32
M
D
L
L
S
S
R
S
P
L
A
E
H
R
P
Site 6
Y42
A
E
H
R
P
D
A
Y
Q
D
V
S
I
H
G
Site 7
S46
P
D
A
Y
Q
D
V
S
I
H
G
T
L
P
R
Site 8
T50
Q
D
V
S
I
H
G
T
L
P
R
K
K
K
G
Site 9
S63
K
G
P
P
P
I
R
S
C
D
D
F
S
H
M
Site 10
T72
D
D
F
S
H
M
G
T
L
P
H
S
K
S
P
Site 11
S76
H
M
G
T
L
P
H
S
K
S
P
R
Q
N
S
Site 12
S78
G
T
L
P
H
S
K
S
P
R
Q
N
S
P
V
Site 13
S83
S
K
S
P
R
Q
N
S
P
V
T
Q
D
G
I
Site 14
T86
P
R
Q
N
S
P
V
T
Q
D
G
I
Q
E
S
Site 15
S93
T
Q
D
G
I
Q
E
S
P
W
Q
D
R
H
G
Site 16
T104
D
R
H
G
E
T
F
T
F
R
D
P
H
L
L
Site 17
T114
D
P
H
L
L
D
P
T
V
E
Y
V
K
F
S
Site 18
Y117
L
L
D
P
T
V
E
Y
V
K
F
S
K
E
R
Site 19
T130
E
R
H
I
M
D
R
T
P
E
K
L
K
K
E
Site 20
S145
L
E
E
E
L
L
L
S
S
E
D
L
R
S
H
Site 21
S146
E
E
E
L
L
L
S
S
E
D
L
R
S
H
A
Site 22
S151
L
S
S
E
D
L
R
S
H
A
W
Y
H
G
R
Site 23
Y155
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
Q
Site 24
S164
G
R
I
P
R
Q
V
S
E
N
L
V
Q
R
D
Site 25
S179
G
D
F
L
V
R
D
S
L
S
S
P
G
N
F
Site 26
S182
L
V
R
D
S
L
S
S
P
G
N
F
V
L
T
Site 27
T204
Q
H
F
K
I
N
R
T
V
L
R
L
S
E
A
Site 28
S209
N
R
T
V
L
R
L
S
E
A
Y
S
R
V
Q
Site 29
Y212
V
L
R
L
S
E
A
Y
S
R
V
Q
Y
Q
F
Site 30
S213
L
R
L
S
E
A
Y
S
R
V
Q
Y
Q
F
E
Site 31
Y217
E
A
Y
S
R
V
Q
Y
Q
F
E
M
E
S
F
Site 32
S223
Q
Y
Q
F
E
M
E
S
F
D
S
I
P
G
L
Site 33
Y234
I
P
G
L
V
R
C
Y
V
G
N
R
R
P
I
Site 34
S242
V
G
N
R
R
P
I
S
Q
Q
S
G
A
I
I
Site 35
S245
R
R
P
I
S
Q
Q
S
G
A
I
I
F
Q
P
Site 36
Y266
L
R
C
L
E
E
H
Y
G
T
S
P
G
Q
A
Site 37
T268
C
L
E
E
H
Y
G
T
S
P
G
Q
A
R
E
Site 38
S269
L
E
E
H
Y
G
T
S
P
G
Q
A
R
E
G
Site 39
S277
P
G
Q
A
R
E
G
S
L
T
K
G
R
P
D
Site 40
T279
Q
A
R
E
G
S
L
T
K
G
R
P
D
V
A
Site 41
S290
P
D
V
A
K
R
L
S
L
T
M
G
G
V
Q
Site 42
T292
V
A
K
R
L
S
L
T
M
G
G
V
Q
A
R
Site 43
S315
L
L
R
N
K
E
K
S
G
S
Q
P
A
C
L
Site 44
S317
R
N
K
E
K
S
G
S
Q
P
A
C
L
D
H
Site 45
S332
M
Q
D
R
R
A
L
S
L
K
A
H
Q
S
E
Site 46
S338
L
S
L
K
A
H
Q
S
E
S
Y
L
P
I
G
Site 47
S340
L
K
A
H
Q
S
E
S
Y
L
P
I
G
C
K
Site 48
Y341
K
A
H
Q
S
E
S
Y
L
P
I
G
C
K
L
Site 49
S352
G
C
K
L
P
P
Q
S
S
G
V
D
T
S
P
Site 50
S353
C
K
L
P
P
Q
S
S
G
V
D
T
S
P
C
Site 51
T357
P
Q
S
S
G
V
D
T
S
P
C
P
N
S
P
Site 52
S358
Q
S
S
G
V
D
T
S
P
C
P
N
S
P
V
Site 53
S363
D
T
S
P
C
P
N
S
P
V
F
R
T
G
S
Site 54
S370
S
P
V
F
R
T
G
S
E
P
A
L
S
P
A
Site 55
S375
T
G
S
E
P
A
L
S
P
A
V
V
R
R
V
Site 56
S383
P
A
V
V
R
R
V
S
S
D
A
R
A
G
E
Site 57
S384
A
V
V
R
R
V
S
S
D
A
R
A
G
E
A
Site 58
S395
A
G
E
A
L
R
G
S
D
S
Q
L
C
P
K
Site 59
S397
E
A
L
R
G
S
D
S
Q
L
C
P
K
P
P
Site 60
S418
P
F
L
K
V
P
S
S
P
S
A
W
L
N
S
Site 61
S420
L
K
V
P
S
S
P
S
A
W
L
N
S
E
A
Site 62
Y429
W
L
N
S
E
A
N
Y
C
E
L
N
P
A
F
Site 63
S448
G
R
G
A
K
L
P
S
C
A
Q
G
S
H
T
Site 64
T459
G
S
H
T
E
L
L
T
A
K
Q
N
E
A
P
Site 65
S471
E
A
P
G
P
R
N
S
G
V
N
Y
L
I
L
Site 66
Y475
P
R
N
S
G
V
N
Y
L
I
L
D
D
D
D
Site 67
T506
W
D
K
G
E
F
V
T
P
L
L
E
T
V
S
Site 68
S513
T
P
L
L
E
T
V
S
S
F
R
P
N
E
F
Site 69
S514
P
L
L
E
T
V
S
S
F
R
P
N
E
F
E
Site 70
S570
V
A
R
I
L
G
V
S
E
E
M
R
R
N
M
Site 71
S580
M
R
R
N
M
G
V
S
S
G
L
E
L
I
T
Site 72
T587
S
S
G
L
E
L
I
T
L
P
H
G
H
Q
L
Site 73
T619
D
I
L
G
C
T
G
T
L
E
D
R
A
A
T
Site 74
Y645
K
D
S
M
G
D
L
Y
S
F
S
A
L
M
K
Site 75
S646
D
S
M
G
D
L
Y
S
F
S
A
L
M
K
A
Site 76
T665
Q
I
T
R
L
E
K
T
W
T
A
L
R
H
Q
Site 77
T667
T
R
L
E
K
T
W
T
A
L
R
H
Q
Y
T
Site 78
Y673
W
T
A
L
R
H
Q
Y
T
Q
T
A
I
L
Y
Site 79
T674
T
A
L
R
H
Q
Y
T
Q
T
A
I
L
Y
E
Site 80
S688
E
K
Q
L
K
P
F
S
K
L
L
H
E
G
R
Site 81
S697
L
L
H
E
G
R
E
S
T
C
V
P
P
N
N
Site 82
T698
L
H
E
G
R
E
S
T
C
V
P
P
N
N
V
Site 83
T723
L
M
E
R
Q
A
V
T
F
E
G
T
D
M
W
Site 84
S756
F
M
A
E
A
A
D
S
Y
R
M
N
A
E
R
Site 85
Y757
M
A
E
A
A
D
S
Y
R
M
N
A
E
R
I
Site 86
S790
Q
M
R
L
L
W
G
S
K
G
A
Q
V
N
Q
Site 87
T798
K
G
A
Q
V
N
Q
T
E
R
Y
E
K
F
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation