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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZMPSTE24
Full Name:
CAAX prenyl protease 1 homolog
Alias:
CAAX prenyl protease 1; EC 3.4.24.84; FACE1; FACE-1; Farnesylated proteins-converting enzyme 1; Prenyl protein-specific endoprotease 1; STE24; Ste24p; Zinc metallopeptidase; Zinc metalloproteinase Ste24
Type:
Protease
Mass (Da):
54813
Number AA:
475
UniProt ID:
O75844
International Prot ID:
IPI00027180
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008235
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y45
A
Q
R
Q
R
R
I
Y
K
T
T
T
H
V
P
Site 2
T47
R
Q
R
R
I
Y
K
T
T
T
H
V
P
P
E
Site 3
T48
Q
R
R
I
Y
K
T
T
T
H
V
P
P
E
L
Site 4
T49
R
R
I
Y
K
T
T
T
H
V
P
P
E
L
G
Site 5
T63
G
Q
I
M
D
S
E
T
F
E
K
S
R
L
Y
Site 6
Y70
T
F
E
K
S
R
L
Y
Q
L
D
K
S
T
F
Site 7
S75
R
L
Y
Q
L
D
K
S
T
F
S
F
W
S
G
Site 8
T76
L
Y
Q
L
D
K
S
T
F
S
F
W
S
G
L
Site 9
S78
Q
L
D
K
S
T
F
S
F
W
S
G
L
Y
S
Site 10
S81
K
S
T
F
S
F
W
S
G
L
Y
S
E
T
E
Site 11
Y84
F
S
F
W
S
G
L
Y
S
E
T
E
G
T
L
Site 12
S85
S
F
W
S
G
L
Y
S
E
T
E
G
T
L
I
Site 13
Y111
L
S
G
R
F
C
G
Y
A
G
F
G
P
E
Y
Site 14
Y118
Y
A
G
F
G
P
E
Y
E
I
T
Q
S
L
V
Site 15
T146
L
P
W
S
L
Y
N
T
F
V
I
E
E
K
H
Site 16
T227
A
P
L
F
D
K
F
T
P
L
P
E
G
K
L
Site 17
Y253
D
F
P
L
T
K
V
Y
V
V
E
G
S
K
R
Site 18
S258
K
V
Y
V
V
E
G
S
K
R
S
S
H
S
N
Site 19
S262
V
E
G
S
K
R
S
S
H
S
N
A
Y
F
Y
Site 20
S264
G
S
K
R
S
S
H
S
N
A
Y
F
Y
G
F
Site 21
Y267
R
S
S
H
S
N
A
Y
F
Y
G
F
F
K
N
Site 22
Y269
S
H
S
N
A
Y
F
Y
G
F
F
K
N
K
R
Site 23
S288
D
T
L
L
E
E
Y
S
V
L
N
K
D
I
Q
Site 24
S298
N
K
D
I
Q
E
D
S
G
M
E
P
R
N
E
Site 25
S310
R
N
E
E
E
G
N
S
E
E
I
K
A
K
V
Site 26
T345
G
H
W
K
L
G
H
T
V
K
N
I
I
I
S
Site 27
S433
G
K
A
K
D
L
Y
S
A
L
I
K
L
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation