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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IDH1
Full Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Alias:
Cytosolic NADP-isocitrate dehydrogenase; IDH; IDHC; IDP; Isocitrate dehydrogenase 1 (NADP+) soluble; NADP+-specific ICDH; Oxalosuccinate decarboxylase; PICD
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Mass (Da):
46659
Number AA:
414
UniProt ID:
O75874
International Prot ID:
IPI00027223
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0051287
GO:0004450
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006740
GO:0006097
GO:0006102
Phosida
TranscriptoNet
STRING
Kinexus Products
Isocitrate dehydrogenase [NADP] cytoplasmic (I129-Y135, human) peptide - Powder PE-01BFR99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFR99#Isocitrate dehydrogenase [NADP] cytoplasmic (I129-Y135, human) peptide - Powder PE-01BFS99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFS99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
K
K
I
S
G
G
S
V
V
E
M
Site 2
S9
S
K
K
I
S
G
G
S
V
V
E
M
Q
G
D
Site 3
T19
E
M
Q
G
D
E
M
T
R
I
I
W
E
L
I
Site 4
Y34
K
E
K
L
I
F
P
Y
V
E
L
D
L
H
S
Site 5
S41
Y
V
E
L
D
L
H
S
Y
D
L
G
I
E
N
Site 6
Y42
V
E
L
D
L
H
S
Y
D
L
G
I
E
N
R
Site 7
T52
G
I
E
N
R
D
A
T
N
D
Q
V
T
K
D
Site 8
T75
N
V
G
V
K
C
A
T
I
T
P
D
E
K
R
Site 9
T77
G
V
K
C
A
T
I
T
P
D
E
K
R
V
E
Site 10
S94
K
L
K
Q
M
W
K
S
P
N
G
T
I
R
N
Site 11
T98
M
W
K
S
P
N
G
T
I
R
N
I
L
G
G
Site 12
Y135
I
I
I
G
R
H
A
Y
G
D
Q
Y
R
A
T
Site 13
Y139
R
H
A
Y
G
D
Q
Y
R
A
T
D
F
V
V
Site 14
T142
Y
G
D
Q
Y
R
A
T
D
F
V
V
P
G
P
Site 15
T155
G
P
G
K
V
E
I
T
Y
T
P
S
D
G
T
Site 16
Y156
P
G
K
V
E
I
T
Y
T
P
S
D
G
T
Q
Site 17
T157
G
K
V
E
I
T
Y
T
P
S
D
G
T
Q
K
Site 18
Y167
D
G
T
Q
K
V
T
Y
L
V
H
N
F
E
E
Site 19
Y183
G
G
V
A
M
G
M
Y
N
Q
D
K
S
I
E
Site 20
S196
I
E
D
F
A
H
S
S
F
Q
M
A
L
S
K
Site 21
Y208
L
S
K
G
W
P
L
Y
L
S
T
K
N
T
I
Site 22
S210
K
G
W
P
L
Y
L
S
T
K
N
T
I
L
K
Site 23
T214
L
Y
L
S
T
K
N
T
I
L
K
K
Y
D
G
Site 24
Y219
K
N
T
I
L
K
K
Y
D
G
R
F
K
D
I
Site 25
Y231
K
D
I
F
Q
E
I
Y
D
K
Q
Y
K
S
Q
Site 26
Y235
Q
E
I
Y
D
K
Q
Y
K
S
Q
F
E
A
Q
Site 27
S278
N
Y
D
G
D
V
Q
S
D
S
V
A
Q
G
Y
Site 28
S280
D
G
D
V
Q
S
D
S
V
A
Q
G
Y
G
S
Site 29
Y285
S
D
S
V
A
Q
G
Y
G
S
L
G
M
M
T
Site 30
T302
L
V
C
P
D
G
K
T
V
E
A
E
A
A
H
Site 31
Y316
H
G
T
V
T
R
H
Y
R
M
Y
Q
K
G
Q
Site 32
Y319
V
T
R
H
Y
R
M
Y
Q
K
G
Q
E
T
S
Site 33
S326
Y
Q
K
G
Q
E
T
S
T
N
P
I
A
S
I
Site 34
S332
T
S
T
N
P
I
A
S
I
F
A
W
T
R
G
Site 35
S389
G
L
P
N
V
Q
R
S
D
Y
L
N
T
F
E
Site 36
Y391
P
N
V
Q
R
S
D
Y
L
N
T
F
E
F
M
Site 37
T394
Q
R
S
D
Y
L
N
T
F
E
F
M
D
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation