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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP7B1
Full Name:
25-hydroxycholesterol 7-alpha-hydroxylase
Alias:
Cytochrome P450 7B1
Type:
Mass (Da):
58256
Number AA:
506
UniProt ID:
O75881
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
G
E
V
S
A
A
T
G
R
F
S
L
E
R
Site 2
S13
S
A
A
T
G
R
F
S
L
E
R
L
G
L
P
Site 3
T40
L
C
L
L
V
R
R
T
R
R
P
G
E
P
P
Site 4
T72
D
P
L
R
F
M
K
T
L
Q
K
Q
H
G
D
Site 5
T80
L
Q
K
Q
H
G
D
T
F
T
V
L
L
G
G
Site 6
T82
K
Q
H
G
D
T
F
T
V
L
L
G
G
K
Y
Site 7
S110
I
K
N
H
K
Q
L
S
F
R
V
F
S
N
K
Site 8
S115
Q
L
S
F
R
V
F
S
N
K
L
L
E
K
A
Site 9
S124
K
L
L
E
K
A
F
S
I
S
Q
L
Q
K
N
Site 10
S126
L
E
K
A
F
S
I
S
Q
L
Q
K
N
H
D
Site 11
Y142
N
D
E
L
H
L
C
Y
Q
F
L
Q
G
K
S
Site 12
S149
Y
Q
F
L
Q
G
K
S
L
D
I
L
L
E
S
Site 13
S156
S
L
D
I
L
L
E
S
M
M
Q
N
L
K
Q
Site 14
S174
P
Q
L
L
K
T
T
S
W
D
T
A
E
L
Y
Site 15
T177
L
K
T
T
S
W
D
T
A
E
L
Y
P
F
C
Site 16
S240
E
L
L
G
N
V
K
S
I
R
E
K
I
I
K
Site 17
S250
E
K
I
I
K
C
F
S
S
E
K
L
A
K
M
Site 18
S266
G
W
S
E
V
F
Q
S
R
Q
D
V
L
E
K
Site 19
Y274
R
Q
D
V
L
E
K
Y
Y
V
H
E
D
L
E
Site 20
Y275
Q
D
V
L
E
K
Y
Y
V
H
E
D
L
E
I
Site 21
Y306
P
T
M
F
W
A
M
Y
Y
L
L
R
H
P
E
Site 22
T329
I
D
R
L
L
Q
S
T
G
Q
K
K
G
S
G
Site 23
T342
S
G
F
P
I
H
L
T
R
E
Q
L
D
S
L
Site 24
S348
L
T
R
E
Q
L
D
S
L
I
C
L
E
S
S
Site 25
S355
S
L
I
C
L
E
S
S
I
F
E
A
L
R
L
Site 26
S364
F
E
A
L
R
L
S
S
Y
S
T
T
I
R
F
Site 27
S366
A
L
R
L
S
S
Y
S
T
T
I
R
F
V
E
Site 28
T367
L
R
L
S
S
Y
S
T
T
I
R
F
V
E
E
Site 29
T368
R
L
S
S
Y
S
T
T
I
R
F
V
E
E
D
Site 30
T377
R
F
V
E
E
D
L
T
L
S
S
E
T
G
D
Site 31
S379
V
E
E
D
L
T
L
S
S
E
T
G
D
Y
C
Site 32
S380
E
E
D
L
T
L
S
S
E
T
G
D
Y
C
V
Site 33
Y385
L
S
S
E
T
G
D
Y
C
V
R
K
G
D
L
Site 34
Y415
E
A
P
E
E
F
R
Y
D
R
F
I
E
D
G
Site 35
T427
E
D
G
K
K
K
T
T
F
F
K
R
G
K
K
Site 36
Y438
R
G
K
K
L
K
C
Y
L
M
P
F
G
T
G
Site 37
S496
F
G
I
Q
Y
P
D
S
D
V
L
F
R
Y
K
Site 38
Y502
D
S
D
V
L
F
R
Y
K
V
K
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation