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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAM2
Full Name:
Signal transducing adapter molecule 2
Alias:
HBP; HRS binding protein; Hrs-binding protein; HSE1; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; Signal transducing adaptor molecule 2A; Signal transducing adaptor molecule 2B
Type:
Transcription protein
Mass (Da):
58164
Number AA:
525
UniProt ID:
O75886
International Prot ID:
IPI00290542
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Signal transducing adapter molecule 2 Y374 phosphosite-specific antibody AB-PN538#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN538#Signal transducing adapter molecule 2 (Y371-L377, human) pY374 phosphopeptide - Powder PE-04AEF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEF95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
D
I
C
D
K
V
G
S
T
P
N
G
A
K
D
Site 2
T39
I
C
D
K
V
G
S
T
P
N
G
A
K
D
C
Site 3
S111
K
V
C
E
K
L
K
S
L
M
V
E
W
S
E
Site 4
S117
K
S
L
M
V
E
W
S
E
E
F
Q
K
D
P
Site 5
T142
S
M
K
E
E
G
I
T
F
P
P
A
G
S
Q
Site 6
T150
F
P
P
A
G
S
Q
T
V
S
A
A
A
K
N
Site 7
S152
P
A
G
S
Q
T
V
S
A
A
A
K
N
G
T
Site 8
T159
S
A
A
A
K
N
G
T
S
S
N
K
N
K
E
Site 9
S160
A
A
A
K
N
G
T
S
S
N
K
N
K
E
D
Site 10
S161
A
A
K
N
G
T
S
S
N
K
N
K
E
D
E
Site 11
S177
I
A
K
A
I
E
L
S
L
Q
E
Q
K
Q
Q
Site 12
T186
Q
E
Q
K
Q
Q
H
T
E
T
K
S
L
Y
P
Site 13
T188
Q
K
Q
Q
H
T
E
T
K
S
L
Y
P
S
S
Site 14
S190
Q
Q
H
T
E
T
K
S
L
Y
P
S
S
E
I
Site 15
Y192
H
T
E
T
K
S
L
Y
P
S
S
E
I
Q
L
Site 16
S194
E
T
K
S
L
Y
P
S
S
E
I
Q
L
N
N
Site 17
S195
T
K
S
L
Y
P
S
S
E
I
Q
L
N
N
K
Site 18
Y211
A
R
K
V
R
A
L
Y
D
F
E
A
V
E
D
Site 19
T222
A
V
E
D
N
E
L
T
F
K
H
G
E
I
I
Site 20
S285
D
V
E
E
I
K
K
S
E
P
E
P
V
Y
I
Site 21
Y291
K
S
E
P
E
P
V
Y
I
D
E
D
K
M
D
Site 22
S306
R
A
L
Q
V
L
Q
S
I
D
P
T
D
S
K
Site 23
T310
V
L
Q
S
I
D
P
T
D
S
K
P
D
S
Q
Site 24
S312
Q
S
I
D
P
T
D
S
K
P
D
S
Q
D
L
Site 25
S316
P
T
D
S
K
P
D
S
Q
D
L
L
D
L
E
Site 26
S345
E
E
I
D
R
K
H
S
E
L
S
E
L
N
V
Site 27
Y371
L
V
N
E
A
P
V
Y
S
V
Y
S
K
L
H
Site 28
S372
V
N
E
A
P
V
Y
S
V
Y
S
K
L
H
P
Site 29
Y374
E
A
P
V
Y
S
V
Y
S
K
L
H
P
P
A
Signal transducing adapter molecule 2 Y374 phosphosite-specific antibody AB-PN538#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN538#Signal transducing adapter molecule 2 (Y371-L377, human) pY374 phosphopeptide - Powder PE-04AEF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEF95
Site 30
S375
A
P
V
Y
S
V
Y
S
K
L
H
P
P
A
H
Site 31
Y383
K
L
H
P
P
A
H
Y
P
P
A
S
S
G
V
Site 32
S387
P
A
H
Y
P
P
A
S
S
G
V
P
M
Q
T
Site 33
S388
A
H
Y
P
P
A
S
S
G
V
P
M
Q
T
Y
Site 34
T394
S
S
G
V
P
M
Q
T
Y
P
V
Q
S
H
G
Site 35
Y395
S
G
V
P
M
Q
T
Y
P
V
Q
S
H
G
G
Site 36
Y404
V
Q
S
H
G
G
N
Y
M
G
Q
S
I
H
Q
Site 37
T413
G
Q
S
I
H
Q
V
T
V
A
Q
S
Y
S
L
Site 38
S419
V
T
V
A
Q
S
Y
S
L
G
P
D
Q
I
G
Site 39
S430
D
Q
I
G
P
L
R
S
L
P
P
N
V
N
S
Site 40
S438
L
P
P
N
V
N
S
S
V
T
A
Q
P
A
Q
Site 41
Y448
A
Q
P
A
Q
T
S
Y
L
S
T
G
Q
D
T
Site 42
S450
P
A
Q
T
S
Y
L
S
T
G
Q
D
T
V
S
Site 43
T451
A
Q
T
S
Y
L
S
T
G
Q
D
T
V
S
N
Site 44
T455
Y
L
S
T
G
Q
D
T
V
S
N
P
T
Y
M
Site 45
S457
S
T
G
Q
D
T
V
S
N
P
T
Y
M
N
Q
Site 46
Y461
D
T
V
S
N
P
T
Y
M
N
Q
N
S
N
L
Site 47
S466
P
T
Y
M
N
Q
N
S
N
L
Q
S
A
T
G
Site 48
S470
N
Q
N
S
N
L
Q
S
A
T
G
T
T
A
Y
Site 49
T474
N
L
Q
S
A
T
G
T
T
A
Y
T
Q
Q
M
Site 50
Y477
S
A
T
G
T
T
A
Y
T
Q
Q
M
G
M
S
Site 51
S488
M
G
M
S
V
D
M
S
S
Y
Q
N
T
T
S
Site 52
S489
G
M
S
V
D
M
S
S
Y
Q
N
T
T
S
N
Site 53
T493
D
M
S
S
Y
Q
N
T
T
S
N
L
P
Q
L
Site 54
S495
S
S
Y
Q
N
T
T
S
N
L
P
Q
L
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation