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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH1L1
Full Name:
10-formyltetrahydrofolate dehydrogenase
Alias:
10-FTHFDH; Aldehyde dehydrogenase 1 family member L1; EC 1.5.1.6; FTHFD
Type:
Enzyme - Dehydrogenase
Mass (Da):
98829
Number AA:
902
UniProt ID:
O75891
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0000036
GO:0016155
GO:0016742
PhosphoSite+
KinaseNET
Biological Process:
GO:0009258
GO:0009058
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y56
D
G
V
P
V
F
K
Y
S
R
W
R
A
K
G
Site 2
S102
I
S
A
P
R
H
G
S
I
I
Y
H
P
S
L
Site 3
Y105
P
R
H
G
S
I
I
Y
H
P
S
L
L
P
R
Site 4
S108
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
Site 5
S117
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
Site 6
T159
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
Site 7
Y164
D
D
T
V
S
T
L
Y
N
R
F
L
F
P
E
Site 8
T199
P
Q
P
E
E
G
A
T
Y
E
G
I
Q
K
K
Site 9
Y200
Q
P
E
E
G
A
T
Y
E
G
I
Q
K
K
E
Site 10
T243
E
A
C
E
Q
K
L
T
F
F
N
S
T
L
N
Site 11
S247
Q
K
L
T
F
F
N
S
T
L
N
T
S
G
L
Site 12
T251
F
F
N
S
T
L
N
T
S
G
L
V
P
E
G
Site 13
S344
K
V
L
E
V
E
D
S
T
D
F
F
K
S
G
Site 14
T345
V
L
E
V
E
D
S
T
D
F
F
K
S
G
A
Site 15
S350
D
S
T
D
F
F
K
S
G
A
A
S
V
D
V
Site 16
S354
F
F
K
S
G
A
A
S
V
D
V
V
R
L
V
Site 17
Y379
E
L
E
N
E
D
V
Y
M
A
S
T
F
G
D
Site 18
S405
D
D
E
E
G
E
C
S
I
D
Y
V
E
M
A
Site 19
Y408
E
G
E
C
S
I
D
Y
V
E
M
A
V
N
K
Site 20
T417
E
M
A
V
N
K
R
T
V
R
M
P
H
Q
L
Site 21
T438
V
D
A
E
G
A
K
T
S
E
T
I
N
P
T
Site 22
T441
E
G
A
K
T
S
E
T
I
N
P
T
D
G
S
Site 23
S481
N
G
R
W
G
K
I
S
A
R
D
R
G
R
L
Site 24
Y490
R
D
R
G
R
L
M
Y
R
L
A
D
L
M
E
Site 25
T505
Q
H
Q
E
E
L
A
T
I
E
A
L
D
A
G
Site 26
T557
A
R
P
N
R
N
L
T
L
T
R
K
E
P
V
Site 27
T559
P
N
R
N
L
T
L
T
R
K
E
P
V
G
V
Site 28
S631
N
V
L
P
G
S
G
S
L
V
G
Q
R
L
S
Site 29
S638
S
L
V
G
Q
R
L
S
D
H
P
D
V
R
K
Site 30
T649
D
V
R
K
I
G
F
T
G
S
T
E
V
G
K
Site 31
S651
R
K
I
G
F
T
G
S
T
E
V
G
K
H
I
Site 32
S671
I
S
N
V
K
K
V
S
L
E
L
G
G
K
S
Site 33
S718
G
R
L
F
V
E
D
S
I
H
D
E
F
V
R
Site 34
T744
G
N
P
L
D
R
D
T
D
H
G
P
Q
N
H
Site 35
Y761
H
L
V
K
L
M
E
Y
C
Q
H
G
V
K
E
Site 36
T771
H
G
V
K
E
G
A
T
L
V
C
G
G
N
Q
Site 37
S825
G
D
L
D
A
V
L
S
R
A
N
A
T
E
F
Site 38
Y848
R
D
I
N
K
A
L
Y
V
S
D
K
L
Q
A
Site 39
T857
S
D
K
L
Q
A
G
T
V
F
V
N
T
Y
N
Site 40
S878
P
F
G
G
F
K
Q
S
G
F
G
K
D
L
G
Site 41
Y892
G
E
A
A
L
N
E
Y
L
R
V
K
T
V
T
Site 42
T897
N
E
Y
L
R
V
K
T
V
T
F
E
Y
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation