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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin K
Full Name:
Cyclin-K
Alias:
CCNK; CYCK
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
41293
Number AA:
357
UniProt ID:
O75909
International Prot ID:
IPI00411579
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0000079
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
K
E
N
K
E
N
S
S
P
S
V
T
S
A
Site 2
S9
K
E
N
K
E
N
S
S
P
S
V
T
S
A
N
Site 3
S11
N
K
E
N
S
S
P
S
V
T
S
A
N
L
D
Site 4
T13
E
N
S
S
P
S
V
T
S
A
N
L
D
H
T
Site 5
T34
D
K
K
D
L
A
H
T
P
S
Q
L
E
G
L
Site 6
S36
K
D
L
A
H
T
P
S
Q
L
E
G
L
D
P
Site 7
T45
L
E
G
L
D
P
A
T
E
A
R
Y
R
R
E
Site 8
Y49
D
P
A
T
E
A
R
Y
R
R
E
G
A
R
F
Site 9
T62
R
F
I
F
D
V
G
T
R
L
G
L
H
Y
D
Site 10
T109
L
A
G
K
V
E
E
T
P
K
K
C
K
D
I
Site 11
T119
K
C
K
D
I
I
K
T
A
R
S
L
L
N
D
Site 12
Y167
P
Y
Q
F
L
L
K
Y
A
K
Q
L
K
G
D
Site 13
T196
V
N
D
S
L
C
T
T
L
S
L
Q
W
E
P
Site 14
S198
D
S
L
C
T
T
L
S
L
Q
W
E
P
E
I
Site 15
Y258
C
H
Q
I
L
D
L
Y
S
Q
G
K
Q
Q
M
Site 16
S259
H
Q
I
L
D
L
Y
S
Q
G
K
Q
Q
M
P
Site 17
T269
K
Q
Q
M
P
H
H
T
P
H
Q
L
Q
Q
P
Site 18
S278
H
Q
L
Q
Q
P
P
S
L
Q
P
T
P
Q
V
Site 19
T282
Q
P
P
S
L
Q
P
T
P
Q
V
P
Q
V
Q
Site 20
S291
Q
V
P
Q
V
Q
Q
S
Q
P
S
Q
S
S
E
Site 21
S294
Q
V
Q
Q
S
Q
P
S
Q
S
S
E
P
S
Q
Site 22
S296
Q
Q
S
Q
P
S
Q
S
S
E
P
S
Q
P
Q
Site 23
S297
Q
S
Q
P
S
Q
S
S
E
P
S
Q
P
Q
Q
Site 24
S300
P
S
Q
S
S
E
P
S
Q
P
Q
Q
K
D
P
Site 25
S324
A
Q
Q
P
K
K
P
S
P
Q
P
S
S
P
R
Site 26
S328
K
K
P
S
P
Q
P
S
S
P
R
Q
V
K
R
Site 27
S329
K
P
S
P
Q
P
S
S
P
R
Q
V
K
R
A
Site 28
S340
V
K
R
A
V
V
V
S
P
K
E
E
N
K
A
Site 29
T361
K
I
P
K
I
E
T
T
H
P
P
L
P
P
A
Site 30
T394
P
P
G
P
V
D
A
T
D
L
P
K
V
Q
I
Site 31
S426
R
P
P
P
P
P
P
S
S
Y
M
T
G
M
S
Site 32
S427
P
P
P
P
P
P
S
S
Y
M
T
G
M
S
T
Site 33
T430
P
P
P
S
S
Y
M
T
G
M
S
T
T
S
S
Site 34
S433
S
S
Y
M
T
G
M
S
T
T
S
S
Y
M
S
Site 35
T434
S
Y
M
T
G
M
S
T
T
S
S
Y
M
S
G
Site 36
S436
M
T
G
M
S
T
T
S
S
Y
M
S
G
E
G
Site 37
S437
T
G
M
S
T
T
S
S
Y
M
S
G
E
G
Y
Site 38
Y438
G
M
S
T
T
S
S
Y
M
S
G
E
G
Y
Q
Site 39
S440
S
T
T
S
S
Y
M
S
G
E
G
Y
Q
S
L
Site 40
Y444
S
Y
M
S
G
E
G
Y
Q
S
L
Q
S
M
M
Site 41
S446
M
S
G
E
G
Y
Q
S
L
Q
S
M
M
K
T
Site 42
S449
E
G
Y
Q
S
L
Q
S
M
M
K
T
E
G
P
Site 43
T453
S
L
Q
S
M
M
K
T
E
G
P
S
Y
G
A
Site 44
Y458
M
K
T
E
G
P
S
Y
G
A
L
P
P
A
Y
Site 45
Y465
Y
G
A
L
P
P
A
Y
G
P
P
A
H
L
P
Site 46
Y478
L
P
Y
H
P
H
V
Y
P
P
N
P
P
P
P
Site 47
S493
P
V
P
P
P
P
A
S
F
P
P
P
A
I
P
Site 48
T503
P
P
A
I
P
P
P
T
P
G
Y
P
P
P
P
Site 49
Y506
I
P
P
P
T
P
G
Y
P
P
P
P
P
T
Y
Site 50
T512
G
Y
P
P
P
P
P
T
Y
N
P
N
F
P
P
Site 51
Y513
Y
P
P
P
P
P
T
Y
N
P
N
F
P
P
P
Site 52
T527
P
P
P
R
L
P
P
T
H
A
V
P
P
H
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation