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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIAS2
Full Name:
E3 SUMO-protein ligase PIAS2
Alias:
Protein inhibitor of activated STAT2
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
68240
Number AA:
621
UniProt ID:
O75928
International Prot ID:
IPI00244407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0019789
GO:0050681
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0019941
GO:0045893
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
E
L
R
N
M
V
S
S
F
R
V
S
E
L
Site 2
S13
E
L
R
N
M
V
S
S
F
R
V
S
E
L
Q
Site 3
S17
M
V
S
S
F
R
V
S
E
L
Q
V
L
L
G
Site 4
S31
G
F
A
G
R
N
K
S
G
R
K
H
D
L
L
Site 5
Y61
Q
I
K
I
R
E
L
Y
R
R
R
Y
P
R
T
Site 6
Y65
R
E
L
Y
R
R
R
Y
P
R
T
L
E
G
L
Site 7
T68
Y
R
R
R
Y
P
R
T
L
E
G
L
S
D
L
Site 8
S73
P
R
T
L
E
G
L
S
D
L
S
T
I
K
S
Site 9
T77
E
G
L
S
D
L
S
T
I
K
S
S
V
F
S
Site 10
S80
S
D
L
S
T
I
K
S
S
V
F
S
L
D
G
Site 11
S81
D
L
S
T
I
K
S
S
V
F
S
L
D
G
G
Site 12
S84
T
I
K
S
S
V
F
S
L
D
G
G
S
S
P
Site 13
S89
V
F
S
L
D
G
G
S
S
P
V
E
P
D
L
Site 14
S90
F
S
L
D
G
G
S
S
P
V
E
P
D
L
A
Site 15
S106
A
G
I
H
S
L
P
S
T
S
V
T
P
H
S
Site 16
T107
G
I
H
S
L
P
S
T
S
V
T
P
H
S
P
Site 17
S108
I
H
S
L
P
S
T
S
V
T
P
H
S
P
S
Site 18
T110
S
L
P
S
T
S
V
T
P
H
S
P
S
S
P
Site 19
S113
S
T
S
V
T
P
H
S
P
S
S
P
V
G
S
Site 20
S115
S
V
T
P
H
S
P
S
S
P
V
G
S
V
L
Site 21
S116
V
T
P
H
S
P
S
S
P
V
G
S
V
L
L
Site 22
S120
S
P
S
S
P
V
G
S
V
L
L
Q
D
T
K
Site 23
T126
G
S
V
L
L
Q
D
T
K
P
T
F
E
M
Q
Site 24
T129
L
L
Q
D
T
K
P
T
F
E
M
Q
Q
P
S
Site 25
S136
T
F
E
M
Q
Q
P
S
P
P
I
P
P
V
H
Site 26
Y154
Q
L
K
N
L
P
F
Y
D
V
L
D
V
L
I
Site 27
S169
K
P
T
S
L
V
Q
S
S
I
Q
R
F
Q
E
Site 28
S170
P
T
S
L
V
Q
S
S
I
Q
R
F
Q
E
K
Site 29
S194
Q
V
R
E
I
C
I
S
R
D
F
L
P
G
G
Site 30
Y205
L
P
G
G
R
R
D
Y
T
V
Q
V
Q
L
R
Site 31
T206
P
G
G
R
R
D
Y
T
V
Q
V
Q
L
R
L
Site 32
T218
L
R
L
C
L
A
E
T
S
C
P
Q
E
D
N
Site 33
Y226
S
C
P
Q
E
D
N
Y
P
N
S
L
C
I
K
Site 34
Y244
K
L
F
P
L
P
G
Y
A
P
P
P
K
N
G
Site 35
T264
P
G
R
P
L
N
I
T
S
L
V
R
L
S
S
Site 36
S280
V
P
N
Q
I
S
I
S
W
A
S
E
I
G
K
Site 37
S290
S
E
I
G
K
N
Y
S
M
S
V
Y
L
V
R
Site 38
Y294
K
N
Y
S
M
S
V
Y
L
V
R
Q
L
T
S
Site 39
S319
G
I
R
N
P
D
H
S
R
A
L
I
K
E
K
Site 40
S333
K
L
T
A
D
P
D
S
E
I
A
T
T
S
L
Site 41
T337
D
P
D
S
E
I
A
T
T
S
L
R
V
S
L
Site 42
Y373
Q
C
F
D
A
A
L
Y
L
Q
M
N
E
K
K
Site 43
S438
K
E
A
M
K
V
S
S
Q
P
C
T
K
I
E
Site 44
T442
K
V
S
S
Q
P
C
T
K
I
E
S
S
S
V
Site 45
S446
Q
P
C
T
K
I
E
S
S
S
V
L
S
K
P
Site 46
S447
P
C
T
K
I
E
S
S
S
V
L
S
K
P
C
Site 47
S448
C
T
K
I
E
S
S
S
V
L
S
K
P
C
S
Site 48
T457
L
S
K
P
C
S
V
T
V
A
S
E
A
S
K
Site 49
T473
K
V
D
V
I
D
L
T
I
E
S
S
S
D
E
Site 50
S476
V
I
D
L
T
I
E
S
S
S
D
E
E
E
D
Site 51
S477
I
D
L
T
I
E
S
S
S
D
E
E
E
D
P
Site 52
S478
D
L
T
I
E
S
S
S
D
E
E
E
D
P
P
Site 53
S494
K
R
K
C
I
F
M
S
E
T
Q
S
S
P
T
Site 54
T496
K
C
I
F
M
S
E
T
Q
S
S
P
T
K
G
Site 55
S498
I
F
M
S
E
T
Q
S
S
P
T
K
G
V
L
Site 56
S499
F
M
S
E
T
Q
S
S
P
T
K
G
V
L
M
Site 57
Y507
P
T
K
G
V
L
M
Y
Q
P
S
S
V
R
V
Site 58
S516
P
S
S
V
R
V
P
S
V
T
S
V
D
P
A
Site 59
S528
D
P
A
A
I
P
P
S
L
T
D
Y
S
V
P
Site 60
Y532
I
P
P
S
L
T
D
Y
S
V
P
F
H
H
T
Site 61
S533
P
P
S
L
T
D
Y
S
V
P
F
H
H
T
P
Site 62
T539
Y
S
V
P
F
H
H
T
P
I
S
S
M
S
S
Site 63
S542
P
F
H
H
T
P
I
S
S
M
S
S
D
L
P
Site 64
S543
F
H
H
T
P
I
S
S
M
S
S
D
L
P
G
Site 65
S546
T
P
I
S
S
M
S
S
D
L
P
G
L
D
F
Site 66
T577
D
S
L
T
S
P
L
T
A
S
S
T
S
V
T
Site 67
S580
T
S
P
L
T
A
S
S
T
S
V
T
T
T
S
Site 68
T581
S
P
L
T
A
S
S
T
S
V
T
T
T
S
S
Site 69
S582
P
L
T
A
S
S
T
S
V
T
T
T
S
S
H
Site 70
T584
T
A
S
S
T
S
V
T
T
T
S
S
H
E
S
Site 71
T586
S
S
T
S
V
T
T
T
S
S
H
E
S
S
T
Site 72
S587
S
T
S
V
T
T
T
S
S
H
E
S
S
T
H
Site 73
S588
T
S
V
T
T
T
S
S
H
E
S
S
T
H
V
Site 74
S591
T
T
T
S
S
H
E
S
S
T
H
V
S
S
S
Site 75
S592
T
T
S
S
H
E
S
S
T
H
V
S
S
S
S
Site 76
T593
T
S
S
H
E
S
S
T
H
V
S
S
S
S
S
Site 77
S596
H
E
S
S
T
H
V
S
S
S
S
S
R
S
E
Site 78
S597
E
S
S
T
H
V
S
S
S
S
S
R
S
E
T
Site 79
S598
S
S
T
H
V
S
S
S
S
S
R
S
E
T
G
Site 80
S599
S
T
H
V
S
S
S
S
S
R
S
E
T
G
V
Site 81
S600
T
H
V
S
S
S
S
S
R
S
E
T
G
V
I
Site 82
S602
V
S
S
S
S
S
R
S
E
T
G
V
I
T
S
Site 83
T604
S
S
S
S
R
S
E
T
G
V
I
T
S
S
G
Site 84
T608
R
S
E
T
G
V
I
T
S
S
G
S
N
I
P
Site 85
S610
E
T
G
V
I
T
S
S
G
S
N
I
P
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation